Cargando…

Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma

Background: Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that catalyzes the methylation of nicotinamide (NAM) to generate 1-methyl nicotinamide (MNAM). Although previous studies have shown that NNMT is frequently dysregulated to promote the onset and progression of many malignancies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Weixian, Jing, Yue, Wang, Shuai, Wu, Yan, Sun, Yawei, Zhuang, Jia, Huang, Xiaofeng, Chen, Sheng, Zhang, Xiaoxin, Song, Yuxian, Hu, Qingang, Ni, Yanhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599733/ https://www.ncbi.nlm.nih.gov/pubmed/36291696 http://dx.doi.org/10.3390/biom12101487

Ejemplares similares

Ki-67 is an independent prognostic marker for the recurrence and relapse of oral squamous cell carcinoma
por: Jing, Yue, et al.
Publicado: (2019)

Identification and Validation of PLOD2 as an Adverse Prognostic Biomarker for Oral Squamous Cell Carcinoma
por: Sun, Yawei, et al.
Publicado: (2021)

Multiperspective quantitative tumor–stroma ratio reveals histological areas associated with poor outcomes in oral squamous cell carcinoma
por: Wang, Shuai, et al.
Publicado: (2023)

Higher Ki67 expression in fibroblast like cells at invasive front indicates better clinical outcomes in oral squamous cell carcinoma patients
por: Jing, Yue, et al.
Publicado: (2018)

Identification of Metabolism-Associated Biomarkers for Early and Precise Diagnosis of Oral Squamous Cell Carcinoma
por: Wang, Yuhan, et al.
Publicado: (2022)

Worst Pattern of Perineural Invasion Redefines the Spatial Localization of Nerves in Oral Squamous Cell Carcinoma
por: Fu, Yong, et al.
Publicado: (2021)

CD38 Multi-Functionality in Oral Squamous Cell Carcinoma: Prognostic Implications, Immune Balance, and Immune Checkpoint
por: Ding, Zhuang, et al.
Publicado: (2021)

Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathway
por: Wang, Yujia, et al.
Publicado: (2019)

OXTR(High) stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling
por: Ding, Liang, et al.
Publicado: (2022)

Functional Heterogeneity of Reelin in the Oral Squamous Cell Carcinoma Microenvironment
por: Zhang, Xinwen, et al.
Publicado: (2021)

Expression profile and prognostic value of NNMT in patients with pancreatic cancer
por: Xu, Yong, et al.
Publicado: (2016)

In situ DESI-MSI lipidomic profiles of mucosal margin of oral squamous cell carcinoma
por: Yang, Xihu, et al.
Publicado: (2021)

Halofuginone inhibits tumor migration and invasion by affecting cancer-associated fibroblasts in oral squamous cell carcinoma
por: Wang, Danni, et al.
Publicado: (2022)

Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma
por: Fu, Yong, et al.
Publicado: (2021)

ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system
por: Zhang, Xiaoxin, et al.
Publicado: (2020)

Vanillin downregulates NNMT and attenuates NNMT-related resistance to 5-fluorouracil via ROS-induced cell apoptosis in colorectal cancer cells
por: Li, Guoli, et al.
Publicado: (2021)

NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer
por: Liu, Wenxiu, et al.
Publicado: (2023)

Lipid Droplet-Related PLIN2 in CD68(+) Tumor-Associated Macrophage of Oral Squamous Cell Carcinoma: Implications for Cancer Prognosis and Immunotherapy
por: He, Yijia, et al.
Publicado: (2022)

Female Specific Association between NNMT Gene and Schizophrenia in a Han Chinese population
por: Wang, Guo-xia, et al.
Publicado: (2014)

Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT)
por: van Haren, Matthijs J., et al.
Publicado: (2021)

Crosstalk between the HIF-1 and Toll-like receptor/nuclear factor-κB pathways in the oral squamous cell carcinoma microenvironment
por: Han, Shengwei, et al.
Publicado: (2016)

Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity
por: Gao, Yongzhi, et al.
Publicado: (2019)

Tensile force-induced PDGF-BB/PDGFRβ signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement
por: Jin, Yuqin, et al.
Publicado: (2020)

ICOSLG-associated immunological landscape and diagnostic value in oral squamous cell carcinoma: a prospective cohort study
por: Dong, Yuexin, et al.
Publicado: (2023)

NNMT: Mean-Field Based Analysis Tools for Neuronal Network Models
por: Layer, Moritz, et al.
Publicado: (2022)

High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer
por: Song, Mengmeng, et al.
Publicado: (2020)

Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma
por: Li, Qiang, et al.
Publicado: (2020)

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink
por: Ulanovskaya, Olesya A., et al.
Publicado: (2013)

Proteomics reveals NNMT as a master metabolic regulator of cancer associated fibroblasts
por: Eckert, Mark A., et al.
Publicado: (2019)

Overexpression of NNMT in Glioma Aggravates Tumor Cell Progression: An Emerging Therapeutic Target
por: Sun, Wei, et al.
Publicado: (2022)

Prognostic Factors of Primary Intraosseous Squamous Cell Carcinoma (PIOSCC): A Retrospective Review
por: Wenguang, Xu, et al.
Publicado: (2016)

NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition
por: Wu, Changqing, et al.
Publicado: (2022)

Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension
por: Fedorowicz, Andrzej, et al.
Publicado: (2016)

NNMT activation can contribute to the development of fatty liver disease by modulating the NAD(+) metabolism
por: Komatsu, Motoaki, et al.
Publicado: (2018)

Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT
por: Kanska, Justyna, et al.
Publicado: (2017)

Correlation of NNMT and DKK1 Protein Expression With Clinicopathological Characteristics and Prognosis of Breast Cancer
por: Liang, Tairong, et al.
Publicado: (2023)

Evaluation of the anti-biofilm effect of poloxamer-based thermoreversible gel of silver nanoparticles as a potential medication for root canal therapy
por: Liu, Ting, et al.
Publicado: (2021)

NNMT depletion contributes to liver cancer cell survival by enhancing autophagy under nutrient starvation
por: Shin, Ji Hye, et al.
Publicado: (2018)

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
por: Dimet-Wiley, Andrea, et al.
Publicado: (2022)

Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis
por: Roberti, Annalisa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vd1hl36an6d4gl4ietp07bua5c