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Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND) and has emerged, among the disorders, with the largest increase in incidence in Western countries. Although the typical clinical phenotype of ALS involves simultaneous upper and lower motor neurons, there is growing ev...

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Autores principales: Urso, Daniele, Zoccolella, Stefano, Gnoni, Valentina, Logroscino, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599737/
https://www.ncbi.nlm.nih.gov/pubmed/36289799
http://dx.doi.org/10.3390/biomedicines10102537
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author Urso, Daniele
Zoccolella, Stefano
Gnoni, Valentina
Logroscino, Giancarlo
author_facet Urso, Daniele
Zoccolella, Stefano
Gnoni, Valentina
Logroscino, Giancarlo
author_sort Urso, Daniele
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND) and has emerged, among the disorders, with the largest increase in incidence in Western countries. Although the typical clinical phenotype of ALS involves simultaneous upper and lower motor neurons, there is growing evidence that the neurodegeneration during the course of the disease can also involve other motor and non-motor regions. In this review, we analyzed and discussed available data from epidemiological population-based studies on extrapyramidal and non-motor features during the course of ALS.
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spelling pubmed-95997372022-10-27 Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features Urso, Daniele Zoccolella, Stefano Gnoni, Valentina Logroscino, Giancarlo Biomedicines Review Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND) and has emerged, among the disorders, with the largest increase in incidence in Western countries. Although the typical clinical phenotype of ALS involves simultaneous upper and lower motor neurons, there is growing evidence that the neurodegeneration during the course of the disease can also involve other motor and non-motor regions. In this review, we analyzed and discussed available data from epidemiological population-based studies on extrapyramidal and non-motor features during the course of ALS. MDPI 2022-10-11 /pmc/articles/PMC9599737/ /pubmed/36289799 http://dx.doi.org/10.3390/biomedicines10102537 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Urso, Daniele
Zoccolella, Stefano
Gnoni, Valentina
Logroscino, Giancarlo
Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features
title Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features
title_full Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features
title_fullStr Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features
title_full_unstemmed Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features
title_short Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features
title_sort amyotrophic lateral sclerosis—the complex phenotype—from an epidemiological perspective: a focus on extrapyramidal and non-motor features
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599737/
https://www.ncbi.nlm.nih.gov/pubmed/36289799
http://dx.doi.org/10.3390/biomedicines10102537
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