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Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND) and has emerged, among the disorders, with the largest increase in incidence in Western countries. Although the typical clinical phenotype of ALS involves simultaneous upper and lower motor neurons, there is growing ev...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599737/ https://www.ncbi.nlm.nih.gov/pubmed/36289799 http://dx.doi.org/10.3390/biomedicines10102537 |
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author | Urso, Daniele Zoccolella, Stefano Gnoni, Valentina Logroscino, Giancarlo |
author_facet | Urso, Daniele Zoccolella, Stefano Gnoni, Valentina Logroscino, Giancarlo |
author_sort | Urso, Daniele |
collection | PubMed |
description | Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND) and has emerged, among the disorders, with the largest increase in incidence in Western countries. Although the typical clinical phenotype of ALS involves simultaneous upper and lower motor neurons, there is growing evidence that the neurodegeneration during the course of the disease can also involve other motor and non-motor regions. In this review, we analyzed and discussed available data from epidemiological population-based studies on extrapyramidal and non-motor features during the course of ALS. |
format | Online Article Text |
id | pubmed-9599737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95997372022-10-27 Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features Urso, Daniele Zoccolella, Stefano Gnoni, Valentina Logroscino, Giancarlo Biomedicines Review Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND) and has emerged, among the disorders, with the largest increase in incidence in Western countries. Although the typical clinical phenotype of ALS involves simultaneous upper and lower motor neurons, there is growing evidence that the neurodegeneration during the course of the disease can also involve other motor and non-motor regions. In this review, we analyzed and discussed available data from epidemiological population-based studies on extrapyramidal and non-motor features during the course of ALS. MDPI 2022-10-11 /pmc/articles/PMC9599737/ /pubmed/36289799 http://dx.doi.org/10.3390/biomedicines10102537 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Urso, Daniele Zoccolella, Stefano Gnoni, Valentina Logroscino, Giancarlo Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features |
title | Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features |
title_full | Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features |
title_fullStr | Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features |
title_full_unstemmed | Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features |
title_short | Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features |
title_sort | amyotrophic lateral sclerosis—the complex phenotype—from an epidemiological perspective: a focus on extrapyramidal and non-motor features |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599737/ https://www.ncbi.nlm.nih.gov/pubmed/36289799 http://dx.doi.org/10.3390/biomedicines10102537 |
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