Continued Complexity of Mutations in Omicron Sublineages

The latest SARS-CoV-2 variant of concern (VOC), Omicron (B.1.1.529), has diversified into more than 300 sublineages. With an expanding number of newly emerging sublineages, the mutation profile is also becoming complicated. There exist mutually exclusive and revertant mutations in different sublinea...

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Autores principales: Spratt, Austin N., Kannan, Saathvik R., Sharma, Kalicharan, Sachdev, Shrikesh, Kandasamy, Shree L., Sönnerborg, Anders, Lorson, Christian L., Singh, Kamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599772/
https://www.ncbi.nlm.nih.gov/pubmed/36289855
http://dx.doi.org/10.3390/biomedicines10102593
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author Spratt, Austin N.
Kannan, Saathvik R.
Sharma, Kalicharan
Sachdev, Shrikesh
Kandasamy, Shree L.
Sönnerborg, Anders
Lorson, Christian L.
Singh, Kamal
author_facet Spratt, Austin N.
Kannan, Saathvik R.
Sharma, Kalicharan
Sachdev, Shrikesh
Kandasamy, Shree L.
Sönnerborg, Anders
Lorson, Christian L.
Singh, Kamal
author_sort Spratt, Austin N.
collection PubMed
description The latest SARS-CoV-2 variant of concern (VOC), Omicron (B.1.1.529), has diversified into more than 300 sublineages. With an expanding number of newly emerging sublineages, the mutation profile is also becoming complicated. There exist mutually exclusive and revertant mutations in different sublineages. Omicron sublineages share some common mutations with previous VOCs (Alpha, Beta, Gamma, and Delta), indicating an evolutionary relationship between these VOCs. A diverse mutation profile at the spike–antibody interface, flexibility of the regions harboring mutations, mutation types, and coexisting mutations suggest that SARS-CoV-2’s evolution is far from over.
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spelling pubmed-95997722022-10-27 Continued Complexity of Mutations in Omicron Sublineages Spratt, Austin N. Kannan, Saathvik R. Sharma, Kalicharan Sachdev, Shrikesh Kandasamy, Shree L. Sönnerborg, Anders Lorson, Christian L. Singh, Kamal Biomedicines Article The latest SARS-CoV-2 variant of concern (VOC), Omicron (B.1.1.529), has diversified into more than 300 sublineages. With an expanding number of newly emerging sublineages, the mutation profile is also becoming complicated. There exist mutually exclusive and revertant mutations in different sublineages. Omicron sublineages share some common mutations with previous VOCs (Alpha, Beta, Gamma, and Delta), indicating an evolutionary relationship between these VOCs. A diverse mutation profile at the spike–antibody interface, flexibility of the regions harboring mutations, mutation types, and coexisting mutations suggest that SARS-CoV-2’s evolution is far from over. MDPI 2022-10-16 /pmc/articles/PMC9599772/ /pubmed/36289855 http://dx.doi.org/10.3390/biomedicines10102593 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spratt, Austin N.
Kannan, Saathvik R.
Sharma, Kalicharan
Sachdev, Shrikesh
Kandasamy, Shree L.
Sönnerborg, Anders
Lorson, Christian L.
Singh, Kamal
Continued Complexity of Mutations in Omicron Sublineages
title Continued Complexity of Mutations in Omicron Sublineages
title_full Continued Complexity of Mutations in Omicron Sublineages
title_fullStr Continued Complexity of Mutations in Omicron Sublineages
title_full_unstemmed Continued Complexity of Mutations in Omicron Sublineages
title_short Continued Complexity of Mutations in Omicron Sublineages
title_sort continued complexity of mutations in omicron sublineages
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599772/
https://www.ncbi.nlm.nih.gov/pubmed/36289855
http://dx.doi.org/10.3390/biomedicines10102593
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