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A Paper-Based Electrochemical Sensor Based on PtNP/COF(TFPB−DHzDS)@rGO for Sensitive Detection of Furazolidone
Herein, a paper-based electrochemical sensor based on PtNP/COF(TFPB−DHzDS)@rGO was developed for the sensitive detection of furazolidone. A cluster-like covalent organic framework (COF(TFPB−DHzDS)) was successfully grown on the surface of amino-functional reduced graphene oxide (rGO-NH(2)) to avoid...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599777/ https://www.ncbi.nlm.nih.gov/pubmed/36291041 http://dx.doi.org/10.3390/bios12100904 |
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author | Chen, Rongfang Peng, Xia Song, Yonghai Du, Yan |
author_facet | Chen, Rongfang Peng, Xia Song, Yonghai Du, Yan |
author_sort | Chen, Rongfang |
collection | PubMed |
description | Herein, a paper-based electrochemical sensor based on PtNP/COF(TFPB−DHzDS)@rGO was developed for the sensitive detection of furazolidone. A cluster-like covalent organic framework (COF(TFPB−DHzDS)) was successfully grown on the surface of amino-functional reduced graphene oxide (rGO-NH(2)) to avoid serious self-aggregation, which was further loaded with platinum nanoparticles (PtNPs) with high catalytic activity as nanozyme to obtain PtNP/COF(TFPB−DHzDS)@rGO nanocomposites. The morphology of PtNP/COF(TFPB−DHzDS)@rGO nanocomposites was characterized, and the results showed that the smooth rGO surface became extremely rough after the modification of COF(TFPB−DHzDS). Meanwhile, ultra-small PtNPs with sizes of around 1 nm were precisely anchored on COF(TFPB−DHzDS) to maintain their excellent catalytic activity. The conventional electrodes were used to detect furazolidone and showed a detection limit as low as 5 nM and a linear range from 15 nM to 110 μM. In contrast, the detection limit for the paper-based electrode was 0.23 μM, and the linear range was 0.69–110 μM. The results showed that the paper-based electrode can be used to detect furazolidone. This sensor is a potential candidate for the detection of furazolidone residue in human serum and fish samples. |
format | Online Article Text |
id | pubmed-9599777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95997772022-10-27 A Paper-Based Electrochemical Sensor Based on PtNP/COF(TFPB−DHzDS)@rGO for Sensitive Detection of Furazolidone Chen, Rongfang Peng, Xia Song, Yonghai Du, Yan Biosensors (Basel) Article Herein, a paper-based electrochemical sensor based on PtNP/COF(TFPB−DHzDS)@rGO was developed for the sensitive detection of furazolidone. A cluster-like covalent organic framework (COF(TFPB−DHzDS)) was successfully grown on the surface of amino-functional reduced graphene oxide (rGO-NH(2)) to avoid serious self-aggregation, which was further loaded with platinum nanoparticles (PtNPs) with high catalytic activity as nanozyme to obtain PtNP/COF(TFPB−DHzDS)@rGO nanocomposites. The morphology of PtNP/COF(TFPB−DHzDS)@rGO nanocomposites was characterized, and the results showed that the smooth rGO surface became extremely rough after the modification of COF(TFPB−DHzDS). Meanwhile, ultra-small PtNPs with sizes of around 1 nm were precisely anchored on COF(TFPB−DHzDS) to maintain their excellent catalytic activity. The conventional electrodes were used to detect furazolidone and showed a detection limit as low as 5 nM and a linear range from 15 nM to 110 μM. In contrast, the detection limit for the paper-based electrode was 0.23 μM, and the linear range was 0.69–110 μM. The results showed that the paper-based electrode can be used to detect furazolidone. This sensor is a potential candidate for the detection of furazolidone residue in human serum and fish samples. MDPI 2022-10-21 /pmc/articles/PMC9599777/ /pubmed/36291041 http://dx.doi.org/10.3390/bios12100904 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Rongfang Peng, Xia Song, Yonghai Du, Yan A Paper-Based Electrochemical Sensor Based on PtNP/COF(TFPB−DHzDS)@rGO for Sensitive Detection of Furazolidone |
title | A Paper-Based Electrochemical Sensor Based on PtNP/COF(TFPB−DHzDS)@rGO for Sensitive Detection of Furazolidone |
title_full | A Paper-Based Electrochemical Sensor Based on PtNP/COF(TFPB−DHzDS)@rGO for Sensitive Detection of Furazolidone |
title_fullStr | A Paper-Based Electrochemical Sensor Based on PtNP/COF(TFPB−DHzDS)@rGO for Sensitive Detection of Furazolidone |
title_full_unstemmed | A Paper-Based Electrochemical Sensor Based on PtNP/COF(TFPB−DHzDS)@rGO for Sensitive Detection of Furazolidone |
title_short | A Paper-Based Electrochemical Sensor Based on PtNP/COF(TFPB−DHzDS)@rGO for Sensitive Detection of Furazolidone |
title_sort | paper-based electrochemical sensor based on ptnp/cof(tfpb−dhzds)@rgo for sensitive detection of furazolidone |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599777/ https://www.ncbi.nlm.nih.gov/pubmed/36291041 http://dx.doi.org/10.3390/bios12100904 |
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