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Lysine Crotonylation: An Emerging Player in DNA Damage Response
The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated manner to counteract various genotoxic stresses. L...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599786/ https://www.ncbi.nlm.nih.gov/pubmed/36291637 http://dx.doi.org/10.3390/biom12101428 |
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author | Zhao, Yuqin Hao, Shuailin Wu, Wenchi Li, Youhang Hou, Kaiping Liu, Yu Cui, Wei Xu, Xingzhi Wang, Hailong |
author_facet | Zhao, Yuqin Hao, Shuailin Wu, Wenchi Li, Youhang Hou, Kaiping Liu, Yu Cui, Wei Xu, Xingzhi Wang, Hailong |
author_sort | Zhao, Yuqin |
collection | PubMed |
description | The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated manner to counteract various genotoxic stresses. Lysine crotonylation (Kcr) is a newly identified PTM occurring in both core histone and non-histone proteins in various organisms. This novel PTM is classified as a reversible acylation modification, which is regulated by a variety of acylases and deacylases and the intracellular crotonyl-CoA substrate concentration. Recent studies suggest that Kcr links cellular metabolism with gene regulation and is involved in numerous cellular processes. In this review, we summarize the regulatory mechanisms of Kcr and its functions in DDR, including its involvement in double-strand break (DSB)-induced transcriptional repression, DSB repair, and the DNA replication stress response. |
format | Online Article Text |
id | pubmed-9599786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95997862022-10-27 Lysine Crotonylation: An Emerging Player in DNA Damage Response Zhao, Yuqin Hao, Shuailin Wu, Wenchi Li, Youhang Hou, Kaiping Liu, Yu Cui, Wei Xu, Xingzhi Wang, Hailong Biomolecules Review The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated manner to counteract various genotoxic stresses. Lysine crotonylation (Kcr) is a newly identified PTM occurring in both core histone and non-histone proteins in various organisms. This novel PTM is classified as a reversible acylation modification, which is regulated by a variety of acylases and deacylases and the intracellular crotonyl-CoA substrate concentration. Recent studies suggest that Kcr links cellular metabolism with gene regulation and is involved in numerous cellular processes. In this review, we summarize the regulatory mechanisms of Kcr and its functions in DDR, including its involvement in double-strand break (DSB)-induced transcriptional repression, DSB repair, and the DNA replication stress response. MDPI 2022-10-05 /pmc/articles/PMC9599786/ /pubmed/36291637 http://dx.doi.org/10.3390/biom12101428 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhao, Yuqin Hao, Shuailin Wu, Wenchi Li, Youhang Hou, Kaiping Liu, Yu Cui, Wei Xu, Xingzhi Wang, Hailong Lysine Crotonylation: An Emerging Player in DNA Damage Response |
title | Lysine Crotonylation: An Emerging Player in DNA Damage Response |
title_full | Lysine Crotonylation: An Emerging Player in DNA Damage Response |
title_fullStr | Lysine Crotonylation: An Emerging Player in DNA Damage Response |
title_full_unstemmed | Lysine Crotonylation: An Emerging Player in DNA Damage Response |
title_short | Lysine Crotonylation: An Emerging Player in DNA Damage Response |
title_sort | lysine crotonylation: an emerging player in dna damage response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599786/ https://www.ncbi.nlm.nih.gov/pubmed/36291637 http://dx.doi.org/10.3390/biom12101428 |
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