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A Contact-Free Optical Device for the Detection of Pulmonary Congestion—A Pilot Study

Background: The cost of heart failure hospitalizations in the US alone is over USD 10 billion per year. Over 4 million Americans are hospitalized every year due to heart failure (HF), with a median length of stay of 4 days and an in-hospital mortality rate that exceeds 5%. Hospitalizations of patien...

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Autores principales: Merdler, Ilan, Hochstadt, Aviram, Ghantous, Eihab, Lupu, Lior, Borohovitz, Ariel, Zahler, David, Taieb, Philippe, Sadeh, Ben, Zalevsky, Zeev, Garcia-Monreal, Javier, Shergei, Michael, Shatsky, Maxim, Beck, Yoav, Polani, Sagi, Arbel, Yaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599847/
https://www.ncbi.nlm.nih.gov/pubmed/36290968
http://dx.doi.org/10.3390/bios12100833
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author Merdler, Ilan
Hochstadt, Aviram
Ghantous, Eihab
Lupu, Lior
Borohovitz, Ariel
Zahler, David
Taieb, Philippe
Sadeh, Ben
Zalevsky, Zeev
Garcia-Monreal, Javier
Shergei, Michael
Shatsky, Maxim
Beck, Yoav
Polani, Sagi
Arbel, Yaron
author_facet Merdler, Ilan
Hochstadt, Aviram
Ghantous, Eihab
Lupu, Lior
Borohovitz, Ariel
Zahler, David
Taieb, Philippe
Sadeh, Ben
Zalevsky, Zeev
Garcia-Monreal, Javier
Shergei, Michael
Shatsky, Maxim
Beck, Yoav
Polani, Sagi
Arbel, Yaron
author_sort Merdler, Ilan
collection PubMed
description Background: The cost of heart failure hospitalizations in the US alone is over USD 10 billion per year. Over 4 million Americans are hospitalized every year due to heart failure (HF), with a median length of stay of 4 days and an in-hospital mortality rate that exceeds 5%. Hospitalizations of patients with HF can be prevented by early detection of lung congestion. Our study assessed a new contact-free optical medical device used for the early detection of lung congestion. Methods: The Gili system is an FDA-cleared device used for measuring chest motion vibration data. Lung congestion in the study was assessed clinically and verified via two cardiologists. An algorithm was developed using machine learning techniques, and cross-validation of the findings was performed to estimate the accuracy of the algorithm. Results: A total of 227 patients were recruited (101 cases vs. 126 controls). The sensitivity and specificity for the device in our study were 0.91 (95% CI: 0.86–0.93) and 0.91 (95% CI: 0.87–0.94), respectively. In all instances, the observed estimates of PPVs and NPVs were at least 0.82 and 0.90, respectively. The accuracy of the algorithm was not affected by different covariates (including respiratory or valvular conditions). Conclusions: This study demonstrates the efficacy of a contact-free optical device for detecting lung congestion. Further validation of the study results across a larger and precise scale is warranted.
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spelling pubmed-95998472022-10-27 A Contact-Free Optical Device for the Detection of Pulmonary Congestion—A Pilot Study Merdler, Ilan Hochstadt, Aviram Ghantous, Eihab Lupu, Lior Borohovitz, Ariel Zahler, David Taieb, Philippe Sadeh, Ben Zalevsky, Zeev Garcia-Monreal, Javier Shergei, Michael Shatsky, Maxim Beck, Yoav Polani, Sagi Arbel, Yaron Biosensors (Basel) Article Background: The cost of heart failure hospitalizations in the US alone is over USD 10 billion per year. Over 4 million Americans are hospitalized every year due to heart failure (HF), with a median length of stay of 4 days and an in-hospital mortality rate that exceeds 5%. Hospitalizations of patients with HF can be prevented by early detection of lung congestion. Our study assessed a new contact-free optical medical device used for the early detection of lung congestion. Methods: The Gili system is an FDA-cleared device used for measuring chest motion vibration data. Lung congestion in the study was assessed clinically and verified via two cardiologists. An algorithm was developed using machine learning techniques, and cross-validation of the findings was performed to estimate the accuracy of the algorithm. Results: A total of 227 patients were recruited (101 cases vs. 126 controls). The sensitivity and specificity for the device in our study were 0.91 (95% CI: 0.86–0.93) and 0.91 (95% CI: 0.87–0.94), respectively. In all instances, the observed estimates of PPVs and NPVs were at least 0.82 and 0.90, respectively. The accuracy of the algorithm was not affected by different covariates (including respiratory or valvular conditions). Conclusions: This study demonstrates the efficacy of a contact-free optical device for detecting lung congestion. Further validation of the study results across a larger and precise scale is warranted. MDPI 2022-10-06 /pmc/articles/PMC9599847/ /pubmed/36290968 http://dx.doi.org/10.3390/bios12100833 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Merdler, Ilan
Hochstadt, Aviram
Ghantous, Eihab
Lupu, Lior
Borohovitz, Ariel
Zahler, David
Taieb, Philippe
Sadeh, Ben
Zalevsky, Zeev
Garcia-Monreal, Javier
Shergei, Michael
Shatsky, Maxim
Beck, Yoav
Polani, Sagi
Arbel, Yaron
A Contact-Free Optical Device for the Detection of Pulmonary Congestion—A Pilot Study
title A Contact-Free Optical Device for the Detection of Pulmonary Congestion—A Pilot Study
title_full A Contact-Free Optical Device for the Detection of Pulmonary Congestion—A Pilot Study
title_fullStr A Contact-Free Optical Device for the Detection of Pulmonary Congestion—A Pilot Study
title_full_unstemmed A Contact-Free Optical Device for the Detection of Pulmonary Congestion—A Pilot Study
title_short A Contact-Free Optical Device for the Detection of Pulmonary Congestion—A Pilot Study
title_sort contact-free optical device for the detection of pulmonary congestion—a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599847/
https://www.ncbi.nlm.nih.gov/pubmed/36290968
http://dx.doi.org/10.3390/bios12100833
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