Cargando…

The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model

A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior i...

Descripción completa

Detalles Bibliográficos
Autores principales: Dubljević, Olga, Ković, Vanja, Pavković, Željko, Mitić, Miloš, Pešić, Vesna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599889/
https://www.ncbi.nlm.nih.gov/pubmed/36291265
http://dx.doi.org/10.3390/brainsci12101332
_version_ 1784816704651526144
author Dubljević, Olga
Ković, Vanja
Pavković, Željko
Mitić, Miloš
Pešić, Vesna
author_facet Dubljević, Olga
Ković, Vanja
Pavković, Željko
Mitić, Miloš
Pešić, Vesna
author_sort Dubljević, Olga
collection PubMed
description A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2–5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3–5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals’ BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift.
format Online
Article
Text
id pubmed-9599889
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95998892022-10-27 The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model Dubljević, Olga Ković, Vanja Pavković, Željko Mitić, Miloš Pešić, Vesna Brain Sci Article A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2–5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3–5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals’ BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift. MDPI 2022-09-30 /pmc/articles/PMC9599889/ /pubmed/36291265 http://dx.doi.org/10.3390/brainsci12101332 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dubljević, Olga
Ković, Vanja
Pavković, Željko
Mitić, Miloš
Pešić, Vesna
The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model
title The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model
title_full The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model
title_fullStr The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model
title_full_unstemmed The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model
title_short The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model
title_sort influence of unlimited sucrose intake on body weight and behavior—findings from a mouse model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599889/
https://www.ncbi.nlm.nih.gov/pubmed/36291265
http://dx.doi.org/10.3390/brainsci12101332
work_keys_str_mv AT dubljevicolga theinfluenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel
AT kovicvanja theinfluenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel
AT pavkoviczeljko theinfluenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel
AT miticmilos theinfluenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel
AT pesicvesna theinfluenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel
AT dubljevicolga influenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel
AT kovicvanja influenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel
AT pavkoviczeljko influenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel
AT miticmilos influenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel
AT pesicvesna influenceofunlimitedsucroseintakeonbodyweightandbehaviorfindingsfromamousemodel