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The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model
A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599889/ https://www.ncbi.nlm.nih.gov/pubmed/36291265 http://dx.doi.org/10.3390/brainsci12101332 |
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author | Dubljević, Olga Ković, Vanja Pavković, Željko Mitić, Miloš Pešić, Vesna |
author_facet | Dubljević, Olga Ković, Vanja Pavković, Željko Mitić, Miloš Pešić, Vesna |
author_sort | Dubljević, Olga |
collection | PubMed |
description | A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2–5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3–5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals’ BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift. |
format | Online Article Text |
id | pubmed-9599889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95998892022-10-27 The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model Dubljević, Olga Ković, Vanja Pavković, Željko Mitić, Miloš Pešić, Vesna Brain Sci Article A potential relationship between unrestricted sucrose intake (USI), overweight, and emotional/behavioral control has not been well documented. We examined the influence of USI and having less sweetness than expected on body weight (BW), motor/exploratory, anxiety-like, and social dominant behavior in adult C57BL/6J male mice. Animals had free access to water (group 1) or 32% sucrose and water (sucrose groups 2–5) for 10 days. Then, group 2 remained with 32% sucrose while groups 3–5 were subjected to the downshift (24 h access to 4%, 8%, or 16% sucrose). All experimental groups were weighed and tested in the novel-open arena (NA), elevated plus maze (EPM), and tube tests to assess BW, motor/exploratory, anxiety-like, and social dominance behavior, respectively. USI did not influence animals’ BW but produced hyperactivity and anxiolytic-like behavior, which was evident in EPM but not in NA; the outcomes of the downshift were comparable. USI did not influence successes/wins in the tube test but altered emotions that drive the winning, favoring a less anxious behavioral phenotype; this was not evident in the downshifted groups. Observed findings suggest that USI promotes sensation-seeking and motivates dominance, without changing BW, while blunted emotional base of social dominance might be an early mark of the downshift. MDPI 2022-09-30 /pmc/articles/PMC9599889/ /pubmed/36291265 http://dx.doi.org/10.3390/brainsci12101332 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dubljević, Olga Ković, Vanja Pavković, Željko Mitić, Miloš Pešić, Vesna The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model |
title | The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model |
title_full | The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model |
title_fullStr | The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model |
title_full_unstemmed | The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model |
title_short | The Influence of Unlimited Sucrose Intake on Body Weight and Behavior—Findings from a Mouse Model |
title_sort | influence of unlimited sucrose intake on body weight and behavior—findings from a mouse model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599889/ https://www.ncbi.nlm.nih.gov/pubmed/36291265 http://dx.doi.org/10.3390/brainsci12101332 |
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