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Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma

Cell–cell junctions comprise various structures, including adherens junctions, tight junctions, desmosomes, and gap junctions. They link cells to each other in tissues and regulate tissue homeostasis in critical cellular processes. Recent advances in cell–cell junction research have led to critical...

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Autores principales: Xu, Qian-Rui, Du, Xiao-Hui, Huang, Ting-Ting, Zheng, Yu-Chun, Li, Yu-Ling, Huang, Dan-Yi, Dai, Hao-Qiang, Li, En-Min, Fang, Wang-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599896/
https://www.ncbi.nlm.nih.gov/pubmed/36291586
http://dx.doi.org/10.3390/biom12101378
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author Xu, Qian-Rui
Du, Xiao-Hui
Huang, Ting-Ting
Zheng, Yu-Chun
Li, Yu-Ling
Huang, Dan-Yi
Dai, Hao-Qiang
Li, En-Min
Fang, Wang-Kai
author_facet Xu, Qian-Rui
Du, Xiao-Hui
Huang, Ting-Ting
Zheng, Yu-Chun
Li, Yu-Ling
Huang, Dan-Yi
Dai, Hao-Qiang
Li, En-Min
Fang, Wang-Kai
author_sort Xu, Qian-Rui
collection PubMed
description Cell–cell junctions comprise various structures, including adherens junctions, tight junctions, desmosomes, and gap junctions. They link cells to each other in tissues and regulate tissue homeostasis in critical cellular processes. Recent advances in cell–cell junction research have led to critical discoveries. Cell–cell adhesion components are important for the invasion and metastasis of tumour cells, which are not only related to cell–cell adhesion changes, but they are also involved in critical molecular signal pathways. They are of great significance, especially given that relevant molecular mechanisms are being discovered, there are an increasing number of emerging biomarkers, targeted therapies are becoming a future therapeutic concern, and there is an increased number of therapeutic agents undergoing clinical trials. Oesophageal squamous cell carcinoma (ESCC), the most common histological subtype of oesophageal cancer, is one of the most common cancers to affect epithelial tissue. ESCC progression is accompanied by the abnormal expression or localisation of components at cell–cell junctions. This review will discuss the recent scientific developments related to the molecules at cell–cell junctions and their role in ESCC to offer valuable insights for readers, provide a global view of the relationships between position, construction, and function, and give a reference for future mechanistic studies, diagnoses, and therapeutic developments.
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spelling pubmed-95998962022-10-27 Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma Xu, Qian-Rui Du, Xiao-Hui Huang, Ting-Ting Zheng, Yu-Chun Li, Yu-Ling Huang, Dan-Yi Dai, Hao-Qiang Li, En-Min Fang, Wang-Kai Biomolecules Review Cell–cell junctions comprise various structures, including adherens junctions, tight junctions, desmosomes, and gap junctions. They link cells to each other in tissues and regulate tissue homeostasis in critical cellular processes. Recent advances in cell–cell junction research have led to critical discoveries. Cell–cell adhesion components are important for the invasion and metastasis of tumour cells, which are not only related to cell–cell adhesion changes, but they are also involved in critical molecular signal pathways. They are of great significance, especially given that relevant molecular mechanisms are being discovered, there are an increasing number of emerging biomarkers, targeted therapies are becoming a future therapeutic concern, and there is an increased number of therapeutic agents undergoing clinical trials. Oesophageal squamous cell carcinoma (ESCC), the most common histological subtype of oesophageal cancer, is one of the most common cancers to affect epithelial tissue. ESCC progression is accompanied by the abnormal expression or localisation of components at cell–cell junctions. This review will discuss the recent scientific developments related to the molecules at cell–cell junctions and their role in ESCC to offer valuable insights for readers, provide a global view of the relationships between position, construction, and function, and give a reference for future mechanistic studies, diagnoses, and therapeutic developments. MDPI 2022-09-26 /pmc/articles/PMC9599896/ /pubmed/36291586 http://dx.doi.org/10.3390/biom12101378 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xu, Qian-Rui
Du, Xiao-Hui
Huang, Ting-Ting
Zheng, Yu-Chun
Li, Yu-Ling
Huang, Dan-Yi
Dai, Hao-Qiang
Li, En-Min
Fang, Wang-Kai
Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma
title Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma
title_full Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma
title_fullStr Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma
title_full_unstemmed Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma
title_short Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma
title_sort role of cell-cell junctions in oesophageal squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599896/
https://www.ncbi.nlm.nih.gov/pubmed/36291586
http://dx.doi.org/10.3390/biom12101378
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