Upregulation of Succinate Dehydrogenase (SDHA) Contributes to Enhanced Bioenergetics of Ovarian Cancer Cells and Higher Sensitivity to Anti-Metabolic Agent Shikonin

SIMPLE SUMMARY: In recent years, targeting tumor specific metabolism has gained an interest as a promising therapeutic strategy. We discovered that the overexpression of mitochondrial enzyme succinate dehydrogenase (SDHA) is highly prevalent in ovarian carcinoma patients and contributes to elevated...

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Detalles Bibliográficos
Autores principales: Wang, Lin, Cybula, Magdalena, Rostworowska, Maria, Wang, Luyao, Mucha, Patryk, Bulicz, Magdalena, Bieniasz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599980/
https://www.ncbi.nlm.nih.gov/pubmed/36291881
http://dx.doi.org/10.3390/cancers14205097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599980/
https://www.ncbi.nlm.nih.gov/pubmed/36291881
http://dx.doi.org/10.3390/cancers14205097

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