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Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT

Limb preservation with megaendoprosthesis in adolescents and young adults (AYA) with bone tumors is associated with functional limitations and gait abnormalities. The proGAIT trial evaluated the effectiveness of an exercise program on gait function and quality of life, functional scales (MSTS, TESS)...

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Autores principales: Basteck, Simon, Guder, Wiebke K., Dirksen, Uta, Krombholz, Arno, Streitbürger, Arne, Reinhardt, Dirk, Götte, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599989/
https://www.ncbi.nlm.nih.gov/pubmed/36290890
http://dx.doi.org/10.3390/curroncol29100613
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author Basteck, Simon
Guder, Wiebke K.
Dirksen, Uta
Krombholz, Arno
Streitbürger, Arne
Reinhardt, Dirk
Götte, Miriam
author_facet Basteck, Simon
Guder, Wiebke K.
Dirksen, Uta
Krombholz, Arno
Streitbürger, Arne
Reinhardt, Dirk
Götte, Miriam
author_sort Basteck, Simon
collection PubMed
description Limb preservation with megaendoprosthesis in adolescents and young adults (AYA) with bone tumors is associated with functional limitations and gait abnormalities. The proGAIT trial evaluated the effectiveness of an exercise program on gait function and quality of life, functional scales (MSTS, TESS), functional mobility, and fatigue as secondary outcomes. Eleven AYA survivors of malignant osteosarcoma with a tumor endoprosthesis around the knee (mean age: 26.6 (±8.4) years) were randomized into an intervention group receiving an 8-week exercise program or into a control group. Gait function was assessed via 3D motion capture and analyzed using the Gait Profile Score (GPS) and the Gait Deviation Index (GDI). GDI and GPS scores of participants suggest deviations from a healthy reference group. The exercise intervention had small-to-medium positive effects on gait score GDI |d| = 0.50 (unaffected leg), |d| = 0.24 (affected leg), subjective functional scores TESS |d| = 0.74 and MSTS |d| = 0.49, and functional tests TUG and TUDS |d| = 0.61 and |d| = 0.52. None of these changes showed statistical significance. Promising intervention effects suggest that regular exercise could improve lower limb function and follow-up care for survivors; however, a powered RCT as a follow-up project needs to confirm the pilot findings.
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spelling pubmed-95999892022-10-27 Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT Basteck, Simon Guder, Wiebke K. Dirksen, Uta Krombholz, Arno Streitbürger, Arne Reinhardt, Dirk Götte, Miriam Curr Oncol Article Limb preservation with megaendoprosthesis in adolescents and young adults (AYA) with bone tumors is associated with functional limitations and gait abnormalities. The proGAIT trial evaluated the effectiveness of an exercise program on gait function and quality of life, functional scales (MSTS, TESS), functional mobility, and fatigue as secondary outcomes. Eleven AYA survivors of malignant osteosarcoma with a tumor endoprosthesis around the knee (mean age: 26.6 (±8.4) years) were randomized into an intervention group receiving an 8-week exercise program or into a control group. Gait function was assessed via 3D motion capture and analyzed using the Gait Profile Score (GPS) and the Gait Deviation Index (GDI). GDI and GPS scores of participants suggest deviations from a healthy reference group. The exercise intervention had small-to-medium positive effects on gait score GDI |d| = 0.50 (unaffected leg), |d| = 0.24 (affected leg), subjective functional scores TESS |d| = 0.74 and MSTS |d| = 0.49, and functional tests TUG and TUDS |d| = 0.61 and |d| = 0.52. None of these changes showed statistical significance. Promising intervention effects suggest that regular exercise could improve lower limb function and follow-up care for survivors; however, a powered RCT as a follow-up project needs to confirm the pilot findings. MDPI 2022-10-14 /pmc/articles/PMC9599989/ /pubmed/36290890 http://dx.doi.org/10.3390/curroncol29100613 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Basteck, Simon
Guder, Wiebke K.
Dirksen, Uta
Krombholz, Arno
Streitbürger, Arne
Reinhardt, Dirk
Götte, Miriam
Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT
title Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT
title_full Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT
title_fullStr Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT
title_full_unstemmed Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT
title_short Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT
title_sort effects of an exercise intervention on gait function in young survivors of osteosarcoma with megaendoprosthesis of the lower extremity—results from the pilot randomized controlled trial progait
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599989/
https://www.ncbi.nlm.nih.gov/pubmed/36290890
http://dx.doi.org/10.3390/curroncol29100613
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