Cargando…
Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study
Catheter-related infections (CRIs) include catheter-associated urinary tract infections (CAUTIs) and central line-associated bloodstream infections (CLABSIs), and they are associated with high morbidity, mortality, and healthcare costs. The diagnosis of a CRI is made difficult by its non-specific sy...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599992/ https://www.ncbi.nlm.nih.gov/pubmed/36292107 http://dx.doi.org/10.3390/diagnostics12102418 |
_version_ | 1784816730449641472 |
---|---|
author | Iftimie, Simona Hernández-Aguilera, Anna López-Azcona, Ana F. Castañé, Helena Rodríguez-Tomàs, Elisabet Baiges-Gaya, Gerard Camps, Jordi Castro, Antoni Joven, Jorge |
author_facet | Iftimie, Simona Hernández-Aguilera, Anna López-Azcona, Ana F. Castañé, Helena Rodríguez-Tomàs, Elisabet Baiges-Gaya, Gerard Camps, Jordi Castro, Antoni Joven, Jorge |
author_sort | Iftimie, Simona |
collection | PubMed |
description | Catheter-related infections (CRIs) include catheter-associated urinary tract infections (CAUTIs) and central line-associated bloodstream infections (CLABSIs), and they are associated with high morbidity, mortality, and healthcare costs. The diagnosis of a CRI is made difficult by its non-specific symptoms. We aimed to investigate the factors influencing the plasma concentration of galectin-3 in catheter-bearing patients and to explore its potential usefulness as an index for CRIs. Circulating the concentrations of galectin-3, we measured the chemokine (C-C) motif ligand 2, procalcitonin, and C-reactive protein in 110 patients with a central catheter, in 165 patients with a urinary catheter, and in 72 control subjects. Catheter-bearing patients had higher concentrations (p < 0.001) of galectin-3 than the control group [central catheter: 19.1 (14.0–23.4) µg/L; urinary catheter: 17.1 (12.7–25.4) µg/L; control group: 6.1 (5.0–8.7) µg/L]. We identified chronic kidney disease as an independent determinant of galectin-3 concentrations in patients with a central catheter, and serum creatinine, cardiovascular disease, and number of days that the catheter was indwelling were identified as determinants in urinary catheter patients. We found that measuring galectin-3 concentrations in urinary catheter patients with a CRI was more accurate for diagnosis than the other parameters. We conclude that the measurement of galectin-3 concentration may be useful for assessing the inflammatory status of catheter-bearing patients and may contribute to the diagnosis of CRIs in those with a urinary catheter. |
format | Online Article Text |
id | pubmed-9599992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95999922022-10-27 Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study Iftimie, Simona Hernández-Aguilera, Anna López-Azcona, Ana F. Castañé, Helena Rodríguez-Tomàs, Elisabet Baiges-Gaya, Gerard Camps, Jordi Castro, Antoni Joven, Jorge Diagnostics (Basel) Article Catheter-related infections (CRIs) include catheter-associated urinary tract infections (CAUTIs) and central line-associated bloodstream infections (CLABSIs), and they are associated with high morbidity, mortality, and healthcare costs. The diagnosis of a CRI is made difficult by its non-specific symptoms. We aimed to investigate the factors influencing the plasma concentration of galectin-3 in catheter-bearing patients and to explore its potential usefulness as an index for CRIs. Circulating the concentrations of galectin-3, we measured the chemokine (C-C) motif ligand 2, procalcitonin, and C-reactive protein in 110 patients with a central catheter, in 165 patients with a urinary catheter, and in 72 control subjects. Catheter-bearing patients had higher concentrations (p < 0.001) of galectin-3 than the control group [central catheter: 19.1 (14.0–23.4) µg/L; urinary catheter: 17.1 (12.7–25.4) µg/L; control group: 6.1 (5.0–8.7) µg/L]. We identified chronic kidney disease as an independent determinant of galectin-3 concentrations in patients with a central catheter, and serum creatinine, cardiovascular disease, and number of days that the catheter was indwelling were identified as determinants in urinary catheter patients. We found that measuring galectin-3 concentrations in urinary catheter patients with a CRI was more accurate for diagnosis than the other parameters. We conclude that the measurement of galectin-3 concentration may be useful for assessing the inflammatory status of catheter-bearing patients and may contribute to the diagnosis of CRIs in those with a urinary catheter. MDPI 2022-10-06 /pmc/articles/PMC9599992/ /pubmed/36292107 http://dx.doi.org/10.3390/diagnostics12102418 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Iftimie, Simona Hernández-Aguilera, Anna López-Azcona, Ana F. Castañé, Helena Rodríguez-Tomàs, Elisabet Baiges-Gaya, Gerard Camps, Jordi Castro, Antoni Joven, Jorge Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study |
title | Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study |
title_full | Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study |
title_fullStr | Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study |
title_full_unstemmed | Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study |
title_short | Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study |
title_sort | measurement of plasma galectin-3 concentrations in patients with catheter infections: a post hoc retrospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599992/ https://www.ncbi.nlm.nih.gov/pubmed/36292107 http://dx.doi.org/10.3390/diagnostics12102418 |
work_keys_str_mv | AT iftimiesimona measurementofplasmagalectin3concentrationsinpatientswithcatheterinfectionsaposthocretrospectivecohortstudy AT hernandezaguileraanna measurementofplasmagalectin3concentrationsinpatientswithcatheterinfectionsaposthocretrospectivecohortstudy AT lopezazconaanaf measurementofplasmagalectin3concentrationsinpatientswithcatheterinfectionsaposthocretrospectivecohortstudy AT castanehelena measurementofplasmagalectin3concentrationsinpatientswithcatheterinfectionsaposthocretrospectivecohortstudy AT rodrigueztomaselisabet measurementofplasmagalectin3concentrationsinpatientswithcatheterinfectionsaposthocretrospectivecohortstudy AT baigesgayagerard measurementofplasmagalectin3concentrationsinpatientswithcatheterinfectionsaposthocretrospectivecohortstudy AT campsjordi measurementofplasmagalectin3concentrationsinpatientswithcatheterinfectionsaposthocretrospectivecohortstudy AT castroantoni measurementofplasmagalectin3concentrationsinpatientswithcatheterinfectionsaposthocretrospectivecohortstudy AT jovenjorge measurementofplasmagalectin3concentrationsinpatientswithcatheterinfectionsaposthocretrospectivecohortstudy |