Cargando…

Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics

Protein palmitoylation is a reversible modification process that links palmitate to cysteine residues via a reversible thioester bond. Palmitoylation exerts an important role in human organ development and tumor progression. However, a comprehensive landscape regarding the dynamic expression of palm...

Descripción completa

Detalles Bibliográficos
Autores principales: Jia, Zixian, Long, Deyu, Yu, Yingcui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600046/
https://www.ncbi.nlm.nih.gov/pubmed/36286021
http://dx.doi.org/10.3390/cimb44100306
_version_ 1784816743988854784
author Jia, Zixian
Long, Deyu
Yu, Yingcui
author_facet Jia, Zixian
Long, Deyu
Yu, Yingcui
author_sort Jia, Zixian
collection PubMed
description Protein palmitoylation is a reversible modification process that links palmitate to cysteine residues via a reversible thioester bond. Palmitoylation exerts an important role in human organ development and tumor progression. However, a comprehensive landscape regarding the dynamic expression of palmitoylation regulators in human organ development remains unclear. In this study, we analyzed the dynamic expression of palmitoylation regulators in seven organ development and eight cancer types based on bioinformatics. We found that the expression levels of most palmitoylation regulators were altered after birth. In particular, ZDHHC7/20/21 exhibited converse expression patterns in multiple cancer types. Survival analysis showed that the poor prognosis in patients with kidney renal clear carcinoma (KIRC) is related to low expression of ZDHHC7/20/21, and a high expression of ZDHHC7/20/21 is related to worse survival in patients with liver hepatocellular carcinoma (LIHC). Furthermore, we found that the expression of ZDHHC7 is associated with infiltration levels of some types of immune cells in the tumor microenvironment (TME), and we explored the relationship between ZDHHC7 expression and immune checkpoint (ICP) genes across 33 cancer types. In addition, gene set enrichment analysis (GSEA) results indicated that ZDHHC7 might regulate different genes to mediate the same pathway in different organs. In summary, the comprehensive analysis of palmitoylation regulators reveals their functions in human organ development and cancer, which may provide new insights for developing new tumor markers.
format Online
Article
Text
id pubmed-9600046
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96000462022-10-27 Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics Jia, Zixian Long, Deyu Yu, Yingcui Curr Issues Mol Biol Article Protein palmitoylation is a reversible modification process that links palmitate to cysteine residues via a reversible thioester bond. Palmitoylation exerts an important role in human organ development and tumor progression. However, a comprehensive landscape regarding the dynamic expression of palmitoylation regulators in human organ development remains unclear. In this study, we analyzed the dynamic expression of palmitoylation regulators in seven organ development and eight cancer types based on bioinformatics. We found that the expression levels of most palmitoylation regulators were altered after birth. In particular, ZDHHC7/20/21 exhibited converse expression patterns in multiple cancer types. Survival analysis showed that the poor prognosis in patients with kidney renal clear carcinoma (KIRC) is related to low expression of ZDHHC7/20/21, and a high expression of ZDHHC7/20/21 is related to worse survival in patients with liver hepatocellular carcinoma (LIHC). Furthermore, we found that the expression of ZDHHC7 is associated with infiltration levels of some types of immune cells in the tumor microenvironment (TME), and we explored the relationship between ZDHHC7 expression and immune checkpoint (ICP) genes across 33 cancer types. In addition, gene set enrichment analysis (GSEA) results indicated that ZDHHC7 might regulate different genes to mediate the same pathway in different organs. In summary, the comprehensive analysis of palmitoylation regulators reveals their functions in human organ development and cancer, which may provide new insights for developing new tumor markers. MDPI 2022-09-27 /pmc/articles/PMC9600046/ /pubmed/36286021 http://dx.doi.org/10.3390/cimb44100306 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jia, Zixian
Long, Deyu
Yu, Yingcui
Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics
title Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics
title_full Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics
title_fullStr Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics
title_full_unstemmed Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics
title_short Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics
title_sort dynamic expression of palmitoylation regulators across human organ development and cancers based on bioinformatics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600046/
https://www.ncbi.nlm.nih.gov/pubmed/36286021
http://dx.doi.org/10.3390/cimb44100306
work_keys_str_mv AT jiazixian dynamicexpressionofpalmitoylationregulatorsacrosshumanorgandevelopmentandcancersbasedonbioinformatics
AT longdeyu dynamicexpressionofpalmitoylationregulatorsacrosshumanorgandevelopmentandcancersbasedonbioinformatics
AT yuyingcui dynamicexpressionofpalmitoylationregulatorsacrosshumanorgandevelopmentandcancersbasedonbioinformatics