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Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics
Protein palmitoylation is a reversible modification process that links palmitate to cysteine residues via a reversible thioester bond. Palmitoylation exerts an important role in human organ development and tumor progression. However, a comprehensive landscape regarding the dynamic expression of palm...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600046/ https://www.ncbi.nlm.nih.gov/pubmed/36286021 http://dx.doi.org/10.3390/cimb44100306 |
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author | Jia, Zixian Long, Deyu Yu, Yingcui |
author_facet | Jia, Zixian Long, Deyu Yu, Yingcui |
author_sort | Jia, Zixian |
collection | PubMed |
description | Protein palmitoylation is a reversible modification process that links palmitate to cysteine residues via a reversible thioester bond. Palmitoylation exerts an important role in human organ development and tumor progression. However, a comprehensive landscape regarding the dynamic expression of palmitoylation regulators in human organ development remains unclear. In this study, we analyzed the dynamic expression of palmitoylation regulators in seven organ development and eight cancer types based on bioinformatics. We found that the expression levels of most palmitoylation regulators were altered after birth. In particular, ZDHHC7/20/21 exhibited converse expression patterns in multiple cancer types. Survival analysis showed that the poor prognosis in patients with kidney renal clear carcinoma (KIRC) is related to low expression of ZDHHC7/20/21, and a high expression of ZDHHC7/20/21 is related to worse survival in patients with liver hepatocellular carcinoma (LIHC). Furthermore, we found that the expression of ZDHHC7 is associated with infiltration levels of some types of immune cells in the tumor microenvironment (TME), and we explored the relationship between ZDHHC7 expression and immune checkpoint (ICP) genes across 33 cancer types. In addition, gene set enrichment analysis (GSEA) results indicated that ZDHHC7 might regulate different genes to mediate the same pathway in different organs. In summary, the comprehensive analysis of palmitoylation regulators reveals their functions in human organ development and cancer, which may provide new insights for developing new tumor markers. |
format | Online Article Text |
id | pubmed-9600046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96000462022-10-27 Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics Jia, Zixian Long, Deyu Yu, Yingcui Curr Issues Mol Biol Article Protein palmitoylation is a reversible modification process that links palmitate to cysteine residues via a reversible thioester bond. Palmitoylation exerts an important role in human organ development and tumor progression. However, a comprehensive landscape regarding the dynamic expression of palmitoylation regulators in human organ development remains unclear. In this study, we analyzed the dynamic expression of palmitoylation regulators in seven organ development and eight cancer types based on bioinformatics. We found that the expression levels of most palmitoylation regulators were altered after birth. In particular, ZDHHC7/20/21 exhibited converse expression patterns in multiple cancer types. Survival analysis showed that the poor prognosis in patients with kidney renal clear carcinoma (KIRC) is related to low expression of ZDHHC7/20/21, and a high expression of ZDHHC7/20/21 is related to worse survival in patients with liver hepatocellular carcinoma (LIHC). Furthermore, we found that the expression of ZDHHC7 is associated with infiltration levels of some types of immune cells in the tumor microenvironment (TME), and we explored the relationship between ZDHHC7 expression and immune checkpoint (ICP) genes across 33 cancer types. In addition, gene set enrichment analysis (GSEA) results indicated that ZDHHC7 might regulate different genes to mediate the same pathway in different organs. In summary, the comprehensive analysis of palmitoylation regulators reveals their functions in human organ development and cancer, which may provide new insights for developing new tumor markers. MDPI 2022-09-27 /pmc/articles/PMC9600046/ /pubmed/36286021 http://dx.doi.org/10.3390/cimb44100306 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jia, Zixian Long, Deyu Yu, Yingcui Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics |
title | Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics |
title_full | Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics |
title_fullStr | Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics |
title_full_unstemmed | Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics |
title_short | Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics |
title_sort | dynamic expression of palmitoylation regulators across human organ development and cancers based on bioinformatics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600046/ https://www.ncbi.nlm.nih.gov/pubmed/36286021 http://dx.doi.org/10.3390/cimb44100306 |
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