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Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy

Background. It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. Methods. A...

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Autores principales: Moliner-Calderón, Elisenda, Verd, Sergio, Leiva, Alfonso, Ponce-Taylor, Jaume, Ginovart, Gemma, Moll-McCarthy, Pia, Gelabert, Catian, Figueras-Aloy, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600066/
https://www.ncbi.nlm.nih.gov/pubmed/36291386
http://dx.doi.org/10.3390/children9101450
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author Moliner-Calderón, Elisenda
Verd, Sergio
Leiva, Alfonso
Ponce-Taylor, Jaume
Ginovart, Gemma
Moll-McCarthy, Pia
Gelabert, Catian
Figueras-Aloy, Josep
author_facet Moliner-Calderón, Elisenda
Verd, Sergio
Leiva, Alfonso
Ponce-Taylor, Jaume
Ginovart, Gemma
Moll-McCarthy, Pia
Gelabert, Catian
Figueras-Aloy, Josep
author_sort Moliner-Calderón, Elisenda
collection PubMed
description Background. It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. Methods. All late preterm and full-term infants from a single center with sepsis findings from 2002 to 2017 were identified. Data on infant feeding during hospital admission were also recorded. Multivariate logistic regression analyses were performed to assess the impact of feeding type on ventilation support and main neonatal morbidities. Results. The total number of participants was 322 (human milk group = 260; exclusive formula group = 62). In the bivariate analysis, 72% of human milk-fed neonates did not require oxygen therapy or respiratory support versus 55% of their formula-fed counterparts (p < 0.0001). Accordingly, invasive mechanical ventilation was required in 9.2% of any human milk-fed infants versus 32% of their exclusively formula-fed counterparts (p = 0.0085). These results held true in multivariate analysis; indeed, any human milk-fed neonates were more likely to require less respiratory support (OR = 0.44; 95% CI:0.22, 0.89) than those who were exclusively formula-fed. Conclusion. Human milk feeding may minimize exposure to mechanical ventilation.
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spelling pubmed-96000662022-10-27 Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy Moliner-Calderón, Elisenda Verd, Sergio Leiva, Alfonso Ponce-Taylor, Jaume Ginovart, Gemma Moll-McCarthy, Pia Gelabert, Catian Figueras-Aloy, Josep Children (Basel) Brief Report Background. It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. Methods. All late preterm and full-term infants from a single center with sepsis findings from 2002 to 2017 were identified. Data on infant feeding during hospital admission were also recorded. Multivariate logistic regression analyses were performed to assess the impact of feeding type on ventilation support and main neonatal morbidities. Results. The total number of participants was 322 (human milk group = 260; exclusive formula group = 62). In the bivariate analysis, 72% of human milk-fed neonates did not require oxygen therapy or respiratory support versus 55% of their formula-fed counterparts (p < 0.0001). Accordingly, invasive mechanical ventilation was required in 9.2% of any human milk-fed infants versus 32% of their exclusively formula-fed counterparts (p = 0.0085). These results held true in multivariate analysis; indeed, any human milk-fed neonates were more likely to require less respiratory support (OR = 0.44; 95% CI:0.22, 0.89) than those who were exclusively formula-fed. Conclusion. Human milk feeding may minimize exposure to mechanical ventilation. MDPI 2022-09-22 /pmc/articles/PMC9600066/ /pubmed/36291386 http://dx.doi.org/10.3390/children9101450 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Moliner-Calderón, Elisenda
Verd, Sergio
Leiva, Alfonso
Ponce-Taylor, Jaume
Ginovart, Gemma
Moll-McCarthy, Pia
Gelabert, Catian
Figueras-Aloy, Josep
Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy
title Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy
title_full Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy
title_fullStr Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy
title_full_unstemmed Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy
title_short Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy
title_sort human milk feeding for septic newborn infants might minimize their exposure to ventilation therapy
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600066/
https://www.ncbi.nlm.nih.gov/pubmed/36291386
http://dx.doi.org/10.3390/children9101450
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