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New Approach Methods for Hazard Identification: A Case Study with Azole Fungicides Affecting Molecular Targets Associated with the Adverse Outcome Pathway for Cholestasis

Triazole fungicides such as propiconazole (Pi) or tebuconazole (Te) show hepatotoxicity in vivo, e.g., hypertrophy and vacuolization of liver cells following interaction with nuclear receptors such as PXR (pregnane-X-receptor) and CAR (constitutive androstane receptor). Accordingly, azoles affect ge...

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Detalles Bibliográficos
Autores principales:	Knebel, Constanze, Süssmuth, Roderich D., Hammer, Helen S., Braeuning, Albert, Marx-Stoelting, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600068/ https://www.ncbi.nlm.nih.gov/pubmed/36291160 http://dx.doi.org/10.3390/cells11203293

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