Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice

Retinoic acid signaling plays an important role in regulating lipid metabolism and inflammation. However, the role of retinoic acid receptor alpha (RARα) in atherosclerosis remains to be determined. In the current study, we investigated the role of macrophage RARα in the development of atheroscleros...

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Autores principales: Cassim Bawa, Fathima N., Gopoju, Raja, Xu, Yanyong, Hu, Shuwei, Zhu, Yingdong, Chen, Shaoru, Jadhav, Kavita, Zhang, Yanqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600071/
https://www.ncbi.nlm.nih.gov/pubmed/36291054
http://dx.doi.org/10.3390/cells11203186
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author Cassim Bawa, Fathima N.
Gopoju, Raja
Xu, Yanyong
Hu, Shuwei
Zhu, Yingdong
Chen, Shaoru
Jadhav, Kavita
Zhang, Yanqiao
author_facet Cassim Bawa, Fathima N.
Gopoju, Raja
Xu, Yanyong
Hu, Shuwei
Zhu, Yingdong
Chen, Shaoru
Jadhav, Kavita
Zhang, Yanqiao
author_sort Cassim Bawa, Fathima N.
collection PubMed
description Retinoic acid signaling plays an important role in regulating lipid metabolism and inflammation. However, the role of retinoic acid receptor alpha (RARα) in atherosclerosis remains to be determined. In the current study, we investigated the role of macrophage RARα in the development of atherosclerosis. Macrophages isolated from myeloid-specific Rarα(-/-) (Rarα(Mac-/-)) mice showed increased lipid accumulation and inflammation and reduced cholesterol efflux compared to Rarα(fl/fl) (control) mice. All-trans retinoic acid (AtRA) induced ATP-binding cassette subfamily A member 1 (Abca1) and Abcg1 expression and cholesterol efflux in both Rarα(Mac-/-) mice and Rarα(fl/fl) mice. In Ldlr(-/-) mice, myeloid ablation of RARα significantly reduced macrophage Abca1 and Abcg1 expression and cholesterol efflux, induced inflammatory genes, and aggravated Western diet-induced atherosclerosis. Our data demonstrate that macrophage RARα protects against atherosclerosis, likely via inducing cholesterol efflux and inhibiting inflammation.
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spelling pubmed-96000712022-10-27 Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice Cassim Bawa, Fathima N. Gopoju, Raja Xu, Yanyong Hu, Shuwei Zhu, Yingdong Chen, Shaoru Jadhav, Kavita Zhang, Yanqiao Cells Article Retinoic acid signaling plays an important role in regulating lipid metabolism and inflammation. However, the role of retinoic acid receptor alpha (RARα) in atherosclerosis remains to be determined. In the current study, we investigated the role of macrophage RARα in the development of atherosclerosis. Macrophages isolated from myeloid-specific Rarα(-/-) (Rarα(Mac-/-)) mice showed increased lipid accumulation and inflammation and reduced cholesterol efflux compared to Rarα(fl/fl) (control) mice. All-trans retinoic acid (AtRA) induced ATP-binding cassette subfamily A member 1 (Abca1) and Abcg1 expression and cholesterol efflux in both Rarα(Mac-/-) mice and Rarα(fl/fl) mice. In Ldlr(-/-) mice, myeloid ablation of RARα significantly reduced macrophage Abca1 and Abcg1 expression and cholesterol efflux, induced inflammatory genes, and aggravated Western diet-induced atherosclerosis. Our data demonstrate that macrophage RARα protects against atherosclerosis, likely via inducing cholesterol efflux and inhibiting inflammation. MDPI 2022-10-11 /pmc/articles/PMC9600071/ /pubmed/36291054 http://dx.doi.org/10.3390/cells11203186 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cassim Bawa, Fathima N.
Gopoju, Raja
Xu, Yanyong
Hu, Shuwei
Zhu, Yingdong
Chen, Shaoru
Jadhav, Kavita
Zhang, Yanqiao
Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice
title Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice
title_full Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice
title_fullStr Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice
title_full_unstemmed Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice
title_short Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice
title_sort retinoic acid receptor alpha (rarα) in macrophages protects from diet-induced atherosclerosis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600071/
https://www.ncbi.nlm.nih.gov/pubmed/36291054
http://dx.doi.org/10.3390/cells11203186
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