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Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation
A 50-year-old woman with no past medical history presented with a left anterior chest wall mass that was clinically soft, mobile, and non-tender. A targeted ultrasound (US) showed findings suggestive of a lipoma. However, focal “mass-like” nodules seen within the inferior portion suggested malignant...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600102/ https://www.ncbi.nlm.nih.gov/pubmed/36292144 http://dx.doi.org/10.3390/diagnostics12102456 |
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author | Goh, Yonggeng Balasundaram, Ghayathri Tan, Hui Min Putti, Thomas Choudary Ng, Celene Wei Qi Fang, Eric Bi, Renzhe Tang, Siau Wei Buhari, Shaik Ahmad Hartman, Mikael Chan, Ching Wan Lim, Yi Ting Olivo, Malini Quek, Swee Tian |
author_facet | Goh, Yonggeng Balasundaram, Ghayathri Tan, Hui Min Putti, Thomas Choudary Ng, Celene Wei Qi Fang, Eric Bi, Renzhe Tang, Siau Wei Buhari, Shaik Ahmad Hartman, Mikael Chan, Ching Wan Lim, Yi Ting Olivo, Malini Quek, Swee Tian |
author_sort | Goh, Yonggeng |
collection | PubMed |
description | A 50-year-old woman with no past medical history presented with a left anterior chest wall mass that was clinically soft, mobile, and non-tender. A targeted ultrasound (US) showed findings suggestive of a lipoma. However, focal “mass-like” nodules seen within the inferior portion suggested malignant transformation of a lipomatous lesion called for cross sectional imaging, such as MRI or invasive biopsy or excision for histological confirmation. A T1-weighted image demonstrated a large lipoma that has a central fat-containing region surrounded by an irregular hypointense rim in the inferior portion, confirming the benignity of the lipoma. An ultrasound-guided photoacoustic imaging (PA) of the excised specimen to derive the biochemical distribution demonstrated the “mass-like” hypoechoic regions on US as fat-containing, suggestive of benignity of lesion, rather than fat-replacing suggestive of malignancy. The case showed the potential of PA as an adjunct to US in improving the diagnostic confidence in lesion characterization. |
format | Online Article Text |
id | pubmed-9600102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96001022022-10-27 Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation Goh, Yonggeng Balasundaram, Ghayathri Tan, Hui Min Putti, Thomas Choudary Ng, Celene Wei Qi Fang, Eric Bi, Renzhe Tang, Siau Wei Buhari, Shaik Ahmad Hartman, Mikael Chan, Ching Wan Lim, Yi Ting Olivo, Malini Quek, Swee Tian Diagnostics (Basel) Interesting Images A 50-year-old woman with no past medical history presented with a left anterior chest wall mass that was clinically soft, mobile, and non-tender. A targeted ultrasound (US) showed findings suggestive of a lipoma. However, focal “mass-like” nodules seen within the inferior portion suggested malignant transformation of a lipomatous lesion called for cross sectional imaging, such as MRI or invasive biopsy or excision for histological confirmation. A T1-weighted image demonstrated a large lipoma that has a central fat-containing region surrounded by an irregular hypointense rim in the inferior portion, confirming the benignity of the lipoma. An ultrasound-guided photoacoustic imaging (PA) of the excised specimen to derive the biochemical distribution demonstrated the “mass-like” hypoechoic regions on US as fat-containing, suggestive of benignity of lesion, rather than fat-replacing suggestive of malignancy. The case showed the potential of PA as an adjunct to US in improving the diagnostic confidence in lesion characterization. MDPI 2022-10-11 /pmc/articles/PMC9600102/ /pubmed/36292144 http://dx.doi.org/10.3390/diagnostics12102456 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Interesting Images Goh, Yonggeng Balasundaram, Ghayathri Tan, Hui Min Putti, Thomas Choudary Ng, Celene Wei Qi Fang, Eric Bi, Renzhe Tang, Siau Wei Buhari, Shaik Ahmad Hartman, Mikael Chan, Ching Wan Lim, Yi Ting Olivo, Malini Quek, Swee Tian Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation |
title | Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation |
title_full | Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation |
title_fullStr | Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation |
title_full_unstemmed | Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation |
title_short | Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation |
title_sort | photoacoustic tomography appearance of fat necrosis: a first-in-human demonstration of biochemical signatures along with histological correlation |
topic | Interesting Images |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600102/ https://www.ncbi.nlm.nih.gov/pubmed/36292144 http://dx.doi.org/10.3390/diagnostics12102456 |
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