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Central Sugar Metabolism and the Cell Wall

The human opportunistic pathogen Aspergillus fumigatus is recognized for its versatile cell wall when it comes to remodeling its components in adaptation to external threats, and this remodeling renders it refractory to antifungals targeting cell wall biosynthesis. A specific role for general sugar...

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Detalles Bibliográficos
Autores principales: Yaakoub, Hajar, Latgé, Jean-Paul, Papon, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600152/
https://www.ncbi.nlm.nih.gov/pubmed/36094091
http://dx.doi.org/10.1128/mbio.02104-22
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author Yaakoub, Hajar
Latgé, Jean-Paul
Papon, Nicolas
author_facet Yaakoub, Hajar
Latgé, Jean-Paul
Papon, Nicolas
author_sort Yaakoub, Hajar
collection PubMed
description The human opportunistic pathogen Aspergillus fumigatus is recognized for its versatile cell wall when it comes to remodeling its components in adaptation to external threats, and this remodeling renders it refractory to antifungals targeting cell wall biosynthesis. A specific role for general sugar metabolism in the regulation of the synthesis of cell wall polymers has been previously demonstrated. Delving deeper into central sugar metabolism may reveal unexpected fundamental aspects in cell wall construction, as shown by the work of Zhou and coworkers (Y. Zhou, K. Yan, Q. Qin, O.G. Raimi, et al., mBio 13:e01426-22, 2022, https://doi.org/10.1128/mbio.01426-22) on the roles of the phosphoglucose isomerase of A. fumigatus in cell wall biosynthesis.
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spelling pubmed-96001522022-10-27 Central Sugar Metabolism and the Cell Wall Yaakoub, Hajar Latgé, Jean-Paul Papon, Nicolas mBio Commentary The human opportunistic pathogen Aspergillus fumigatus is recognized for its versatile cell wall when it comes to remodeling its components in adaptation to external threats, and this remodeling renders it refractory to antifungals targeting cell wall biosynthesis. A specific role for general sugar metabolism in the regulation of the synthesis of cell wall polymers has been previously demonstrated. Delving deeper into central sugar metabolism may reveal unexpected fundamental aspects in cell wall construction, as shown by the work of Zhou and coworkers (Y. Zhou, K. Yan, Q. Qin, O.G. Raimi, et al., mBio 13:e01426-22, 2022, https://doi.org/10.1128/mbio.01426-22) on the roles of the phosphoglucose isomerase of A. fumigatus in cell wall biosynthesis. American Society for Microbiology 2022-09-12 /pmc/articles/PMC9600152/ /pubmed/36094091 http://dx.doi.org/10.1128/mbio.02104-22 Text en Copyright © 2022 Yaakoub et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Yaakoub, Hajar
Latgé, Jean-Paul
Papon, Nicolas
Central Sugar Metabolism and the Cell Wall
title Central Sugar Metabolism and the Cell Wall
title_full Central Sugar Metabolism and the Cell Wall
title_fullStr Central Sugar Metabolism and the Cell Wall
title_full_unstemmed Central Sugar Metabolism and the Cell Wall
title_short Central Sugar Metabolism and the Cell Wall
title_sort central sugar metabolism and the cell wall
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600152/
https://www.ncbi.nlm.nih.gov/pubmed/36094091
http://dx.doi.org/10.1128/mbio.02104-22
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