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Central Sugar Metabolism and the Cell Wall
The human opportunistic pathogen Aspergillus fumigatus is recognized for its versatile cell wall when it comes to remodeling its components in adaptation to external threats, and this remodeling renders it refractory to antifungals targeting cell wall biosynthesis. A specific role for general sugar...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600152/ https://www.ncbi.nlm.nih.gov/pubmed/36094091 http://dx.doi.org/10.1128/mbio.02104-22 |
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author | Yaakoub, Hajar Latgé, Jean-Paul Papon, Nicolas |
author_facet | Yaakoub, Hajar Latgé, Jean-Paul Papon, Nicolas |
author_sort | Yaakoub, Hajar |
collection | PubMed |
description | The human opportunistic pathogen Aspergillus fumigatus is recognized for its versatile cell wall when it comes to remodeling its components in adaptation to external threats, and this remodeling renders it refractory to antifungals targeting cell wall biosynthesis. A specific role for general sugar metabolism in the regulation of the synthesis of cell wall polymers has been previously demonstrated. Delving deeper into central sugar metabolism may reveal unexpected fundamental aspects in cell wall construction, as shown by the work of Zhou and coworkers (Y. Zhou, K. Yan, Q. Qin, O.G. Raimi, et al., mBio 13:e01426-22, 2022, https://doi.org/10.1128/mbio.01426-22) on the roles of the phosphoglucose isomerase of A. fumigatus in cell wall biosynthesis. |
format | Online Article Text |
id | pubmed-9600152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-96001522022-10-27 Central Sugar Metabolism and the Cell Wall Yaakoub, Hajar Latgé, Jean-Paul Papon, Nicolas mBio Commentary The human opportunistic pathogen Aspergillus fumigatus is recognized for its versatile cell wall when it comes to remodeling its components in adaptation to external threats, and this remodeling renders it refractory to antifungals targeting cell wall biosynthesis. A specific role for general sugar metabolism in the regulation of the synthesis of cell wall polymers has been previously demonstrated. Delving deeper into central sugar metabolism may reveal unexpected fundamental aspects in cell wall construction, as shown by the work of Zhou and coworkers (Y. Zhou, K. Yan, Q. Qin, O.G. Raimi, et al., mBio 13:e01426-22, 2022, https://doi.org/10.1128/mbio.01426-22) on the roles of the phosphoglucose isomerase of A. fumigatus in cell wall biosynthesis. American Society for Microbiology 2022-09-12 /pmc/articles/PMC9600152/ /pubmed/36094091 http://dx.doi.org/10.1128/mbio.02104-22 Text en Copyright © 2022 Yaakoub et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Commentary Yaakoub, Hajar Latgé, Jean-Paul Papon, Nicolas Central Sugar Metabolism and the Cell Wall |
title | Central Sugar Metabolism and the Cell Wall |
title_full | Central Sugar Metabolism and the Cell Wall |
title_fullStr | Central Sugar Metabolism and the Cell Wall |
title_full_unstemmed | Central Sugar Metabolism and the Cell Wall |
title_short | Central Sugar Metabolism and the Cell Wall |
title_sort | central sugar metabolism and the cell wall |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600152/ https://www.ncbi.nlm.nih.gov/pubmed/36094091 http://dx.doi.org/10.1128/mbio.02104-22 |
work_keys_str_mv | AT yaakoubhajar centralsugarmetabolismandthecellwall AT latgejeanpaul centralsugarmetabolismandthecellwall AT paponnicolas centralsugarmetabolismandthecellwall |