A Nonadjuvanted Whole-Inactivated Pneumococcal Vaccine Induces Multiserotype Opsonophagocytic Responses Mediated by Noncapsule-Specific Antibodies

Streptococcus pneumoniae (Spn) remains a major cause of global mortality, with extensive antigenic diversity between capsular serotypes that poses an ongoing challenge for vaccine development. Widespread use of pneumococcal conjugate vaccines (PCVs) targeting Spn capsules has greatly reduced infecti...

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Detalles Bibliográficos
Autores principales: David, Shannon C., Brazel, Erin B., Singleton, Eve V., Minhas, Vikrant, Laan, Zoe, Scougall, Catherine, Chen, Austen Y., Wang, Hui, Gates, Chloe J., McLean, Kimberley T., Brown, Jeremy S., Ercoli, Giuseppe, Higgins, Rachel A., Licciardi, Paul V., Mulholland, Kim, Davies, Justin B., Hirst, Timothy R., Paton, James C., Alsharifi, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600166/
https://www.ncbi.nlm.nih.gov/pubmed/36125268
http://dx.doi.org/10.1128/mbio.02367-22

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