Cargando…

The Role of N(6)-Methyladenosine Modification in Microvascular Dysfunction

Microvascular dysfunction (MVD) has long plagued the medical field despite improvements in its prevention, diagnosis, and intervention. Microvascular lesions from MVD increase with age and further lead to impaired microcirculation, target organ dysfunction, and a mass of microvascular complications,...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ye-Ran, Ji, Jiang-Dong, Wang, Jia-Nan, Wang, Ying, Zhu, Hong-Jing, Sun, Ru-Xu, Liu, Qing-Huai, Chen, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600171/
https://www.ncbi.nlm.nih.gov/pubmed/36291060
http://dx.doi.org/10.3390/cells11203193
_version_ 1784816775264731136
author Zhang, Ye-Ran
Ji, Jiang-Dong
Wang, Jia-Nan
Wang, Ying
Zhu, Hong-Jing
Sun, Ru-Xu
Liu, Qing-Huai
Chen, Xue
author_facet Zhang, Ye-Ran
Ji, Jiang-Dong
Wang, Jia-Nan
Wang, Ying
Zhu, Hong-Jing
Sun, Ru-Xu
Liu, Qing-Huai
Chen, Xue
author_sort Zhang, Ye-Ran
collection PubMed
description Microvascular dysfunction (MVD) has long plagued the medical field despite improvements in its prevention, diagnosis, and intervention. Microvascular lesions from MVD increase with age and further lead to impaired microcirculation, target organ dysfunction, and a mass of microvascular complications, thus contributing to a heavy medical burden and rising disability rates. An up-to-date understanding of molecular mechanisms underlying MVD will facilitate discoveries of more effective therapeutic strategies. Recent advances in epigenetics have revealed that RNA methylation, an epigenetic modification, has a pivotal role in vascular events. The N(6)-methylation of adenosine (m(6)A) modification is the most prevalent internal RNA modification in eukaryotic cells, which regulates vascular transcripts through splicing, degradation, translation, as well as translocation, thus maintaining microvascular homeostasis. Conversely, the disruption of the m(6)A regulatory network will lead to MVD. Herein, we provide a review discussing how m(6)A methylation interacts with MVD. We also focus on alterations of the m(6)A regulatory network under pathological conditions. Finally, we highlight the value of m(6)A regulators as prognostic biomarkers and novel therapeutic targets, which might be a promising addition to clinical medicine.
format Online
Article
Text
id pubmed-9600171
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96001712022-10-27 The Role of N(6)-Methyladenosine Modification in Microvascular Dysfunction Zhang, Ye-Ran Ji, Jiang-Dong Wang, Jia-Nan Wang, Ying Zhu, Hong-Jing Sun, Ru-Xu Liu, Qing-Huai Chen, Xue Cells Review Microvascular dysfunction (MVD) has long plagued the medical field despite improvements in its prevention, diagnosis, and intervention. Microvascular lesions from MVD increase with age and further lead to impaired microcirculation, target organ dysfunction, and a mass of microvascular complications, thus contributing to a heavy medical burden and rising disability rates. An up-to-date understanding of molecular mechanisms underlying MVD will facilitate discoveries of more effective therapeutic strategies. Recent advances in epigenetics have revealed that RNA methylation, an epigenetic modification, has a pivotal role in vascular events. The N(6)-methylation of adenosine (m(6)A) modification is the most prevalent internal RNA modification in eukaryotic cells, which regulates vascular transcripts through splicing, degradation, translation, as well as translocation, thus maintaining microvascular homeostasis. Conversely, the disruption of the m(6)A regulatory network will lead to MVD. Herein, we provide a review discussing how m(6)A methylation interacts with MVD. We also focus on alterations of the m(6)A regulatory network under pathological conditions. Finally, we highlight the value of m(6)A regulators as prognostic biomarkers and novel therapeutic targets, which might be a promising addition to clinical medicine. MDPI 2022-10-11 /pmc/articles/PMC9600171/ /pubmed/36291060 http://dx.doi.org/10.3390/cells11203193 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Ye-Ran
Ji, Jiang-Dong
Wang, Jia-Nan
Wang, Ying
Zhu, Hong-Jing
Sun, Ru-Xu
Liu, Qing-Huai
Chen, Xue
The Role of N(6)-Methyladenosine Modification in Microvascular Dysfunction
title The Role of N(6)-Methyladenosine Modification in Microvascular Dysfunction
title_full The Role of N(6)-Methyladenosine Modification in Microvascular Dysfunction
title_fullStr The Role of N(6)-Methyladenosine Modification in Microvascular Dysfunction
title_full_unstemmed The Role of N(6)-Methyladenosine Modification in Microvascular Dysfunction
title_short The Role of N(6)-Methyladenosine Modification in Microvascular Dysfunction
title_sort role of n(6)-methyladenosine modification in microvascular dysfunction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600171/
https://www.ncbi.nlm.nih.gov/pubmed/36291060
http://dx.doi.org/10.3390/cells11203193
work_keys_str_mv AT zhangyeran theroleofn6methyladenosinemodificationinmicrovasculardysfunction
AT jijiangdong theroleofn6methyladenosinemodificationinmicrovasculardysfunction
AT wangjianan theroleofn6methyladenosinemodificationinmicrovasculardysfunction
AT wangying theroleofn6methyladenosinemodificationinmicrovasculardysfunction
AT zhuhongjing theroleofn6methyladenosinemodificationinmicrovasculardysfunction
AT sunruxu theroleofn6methyladenosinemodificationinmicrovasculardysfunction
AT liuqinghuai theroleofn6methyladenosinemodificationinmicrovasculardysfunction
AT chenxue theroleofn6methyladenosinemodificationinmicrovasculardysfunction
AT zhangyeran roleofn6methyladenosinemodificationinmicrovasculardysfunction
AT jijiangdong roleofn6methyladenosinemodificationinmicrovasculardysfunction
AT wangjianan roleofn6methyladenosinemodificationinmicrovasculardysfunction
AT wangying roleofn6methyladenosinemodificationinmicrovasculardysfunction
AT zhuhongjing roleofn6methyladenosinemodificationinmicrovasculardysfunction
AT sunruxu roleofn6methyladenosinemodificationinmicrovasculardysfunction
AT liuqinghuai roleofn6methyladenosinemodificationinmicrovasculardysfunction
AT chenxue roleofn6methyladenosinemodificationinmicrovasculardysfunction