Genomic Instability in Cerebrospinal Fluid Cell-Free DNA Predicts Poor Prognosis in Solid Tumor Patients with Meningeal Metastasis

SIMPLE SUMMARY: We established a genomic instability score using unfiltered sequencing data from meningeal metastasis (MM) cell-free circulating tumor DNA (ctDNA) samples and found that substantial genomic instability (GI) was present in cerebrospinal fluid ctDNA rather than plasma ctDNA, implying t...

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Detalles Bibliográficos
Autores principales: Wang, Peng, Zhang, Qiaoling, Han, Lei, Cheng, Yanan, Sun, Zengfeng, Yin, Qiang, Zhang, Zhen, Yu, Jinpu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600191/
https://www.ncbi.nlm.nih.gov/pubmed/36291812
http://dx.doi.org/10.3390/cancers14205028

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