Cargando…

Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature

The term infertility is defined as the lack of conception within 1 year of unprotected intercourse. It affects more than 80 million individuals worldwide. It is estimated that 10-15% of couples of reproductive age are challenged by reproductive issues. Assisted reproduction techniques (ART) are resp...

Descripción completa

Detalles Bibliográficos
Autores principales: Perros, Paraskevas, Psarris, Alexandros, Antsaklis, Panagiotis, Theodora, Marianna, Syndos, Michael, Koutras, Antonios, Ntounis, Thomas, Fasoulakis, Zaharias, Rodolakis, Alexandros, Daskalakis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600207/
https://www.ncbi.nlm.nih.gov/pubmed/36291447
http://dx.doi.org/10.3390/children9101511
_version_ 1784816784305553408
author Perros, Paraskevas
Psarris, Alexandros
Antsaklis, Panagiotis
Theodora, Marianna
Syndos, Michael
Koutras, Antonios
Ntounis, Thomas
Fasoulakis, Zaharias
Rodolakis, Alexandros
Daskalakis, Georgios
author_facet Perros, Paraskevas
Psarris, Alexandros
Antsaklis, Panagiotis
Theodora, Marianna
Syndos, Michael
Koutras, Antonios
Ntounis, Thomas
Fasoulakis, Zaharias
Rodolakis, Alexandros
Daskalakis, Georgios
author_sort Perros, Paraskevas
collection PubMed
description The term infertility is defined as the lack of conception within 1 year of unprotected intercourse. It affects more than 80 million individuals worldwide. It is estimated that 10-15% of couples of reproductive age are challenged by reproductive issues. Assisted reproduction techniques (ART) are responsible for more than 4% of live births. Our aim is to review the research on neurodevelopmental outcomes of newborns born after the implementation of assisted reproduction methods compared to those conceived naturally. We conducted a comprehensive search of the PubMed, Crossref and Google Scholar electronic databases for related articles up to June 2022 using the PRISMA guidelines. Our research revealed a large number of long term follow-up studies between 2 and 18 years of age, with comparable developmental outcomes. Many studies compared the effects of different infertility treatments against natural conception. The review of the literature revealed that ART is safe, as the majority of studies showed no effect on the neurodevelopmental outcomes of the offspring. In most cases when such an effect was observed, it could be attributed to confounding factors such as subfertility, multiple pregnancies and gestational age at delivery. Finally, the increase in the prevalence of neurodevelopmental disorders after ART, as described in studies with statistically significant results, is predominantly marginal, and given the low incidence of neurodevelopmental disorders in the general population, its clinical significance is debatable.
format Online
Article
Text
id pubmed-9600207
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96002072022-10-27 Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature Perros, Paraskevas Psarris, Alexandros Antsaklis, Panagiotis Theodora, Marianna Syndos, Michael Koutras, Antonios Ntounis, Thomas Fasoulakis, Zaharias Rodolakis, Alexandros Daskalakis, Georgios Children (Basel) Review The term infertility is defined as the lack of conception within 1 year of unprotected intercourse. It affects more than 80 million individuals worldwide. It is estimated that 10-15% of couples of reproductive age are challenged by reproductive issues. Assisted reproduction techniques (ART) are responsible for more than 4% of live births. Our aim is to review the research on neurodevelopmental outcomes of newborns born after the implementation of assisted reproduction methods compared to those conceived naturally. We conducted a comprehensive search of the PubMed, Crossref and Google Scholar electronic databases for related articles up to June 2022 using the PRISMA guidelines. Our research revealed a large number of long term follow-up studies between 2 and 18 years of age, with comparable developmental outcomes. Many studies compared the effects of different infertility treatments against natural conception. The review of the literature revealed that ART is safe, as the majority of studies showed no effect on the neurodevelopmental outcomes of the offspring. In most cases when such an effect was observed, it could be attributed to confounding factors such as subfertility, multiple pregnancies and gestational age at delivery. Finally, the increase in the prevalence of neurodevelopmental disorders after ART, as described in studies with statistically significant results, is predominantly marginal, and given the low incidence of neurodevelopmental disorders in the general population, its clinical significance is debatable. MDPI 2022-10-03 /pmc/articles/PMC9600207/ /pubmed/36291447 http://dx.doi.org/10.3390/children9101511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Perros, Paraskevas
Psarris, Alexandros
Antsaklis, Panagiotis
Theodora, Marianna
Syndos, Michael
Koutras, Antonios
Ntounis, Thomas
Fasoulakis, Zaharias
Rodolakis, Alexandros
Daskalakis, Georgios
Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature
title Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature
title_full Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature
title_fullStr Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature
title_full_unstemmed Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature
title_short Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature
title_sort neurodevelopmental outcomes of pregnancies resulting from assisted reproduction: a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600207/
https://www.ncbi.nlm.nih.gov/pubmed/36291447
http://dx.doi.org/10.3390/children9101511
work_keys_str_mv AT perrosparaskevas neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature
AT psarrisalexandros neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature
AT antsaklispanagiotis neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature
AT theodoramarianna neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature
AT syndosmichael neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature
AT koutrasantonios neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature
AT ntounisthomas neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature
AT fasoulakiszaharias neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature
AT rodolakisalexandros neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature
AT daskalakisgeorgios neurodevelopmentaloutcomesofpregnanciesresultingfromassistedreproductionareviewoftheliterature