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Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature
The term infertility is defined as the lack of conception within 1 year of unprotected intercourse. It affects more than 80 million individuals worldwide. It is estimated that 10-15% of couples of reproductive age are challenged by reproductive issues. Assisted reproduction techniques (ART) are resp...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600207/ https://www.ncbi.nlm.nih.gov/pubmed/36291447 http://dx.doi.org/10.3390/children9101511 |
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author | Perros, Paraskevas Psarris, Alexandros Antsaklis, Panagiotis Theodora, Marianna Syndos, Michael Koutras, Antonios Ntounis, Thomas Fasoulakis, Zaharias Rodolakis, Alexandros Daskalakis, Georgios |
author_facet | Perros, Paraskevas Psarris, Alexandros Antsaklis, Panagiotis Theodora, Marianna Syndos, Michael Koutras, Antonios Ntounis, Thomas Fasoulakis, Zaharias Rodolakis, Alexandros Daskalakis, Georgios |
author_sort | Perros, Paraskevas |
collection | PubMed |
description | The term infertility is defined as the lack of conception within 1 year of unprotected intercourse. It affects more than 80 million individuals worldwide. It is estimated that 10-15% of couples of reproductive age are challenged by reproductive issues. Assisted reproduction techniques (ART) are responsible for more than 4% of live births. Our aim is to review the research on neurodevelopmental outcomes of newborns born after the implementation of assisted reproduction methods compared to those conceived naturally. We conducted a comprehensive search of the PubMed, Crossref and Google Scholar electronic databases for related articles up to June 2022 using the PRISMA guidelines. Our research revealed a large number of long term follow-up studies between 2 and 18 years of age, with comparable developmental outcomes. Many studies compared the effects of different infertility treatments against natural conception. The review of the literature revealed that ART is safe, as the majority of studies showed no effect on the neurodevelopmental outcomes of the offspring. In most cases when such an effect was observed, it could be attributed to confounding factors such as subfertility, multiple pregnancies and gestational age at delivery. Finally, the increase in the prevalence of neurodevelopmental disorders after ART, as described in studies with statistically significant results, is predominantly marginal, and given the low incidence of neurodevelopmental disorders in the general population, its clinical significance is debatable. |
format | Online Article Text |
id | pubmed-9600207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96002072022-10-27 Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature Perros, Paraskevas Psarris, Alexandros Antsaklis, Panagiotis Theodora, Marianna Syndos, Michael Koutras, Antonios Ntounis, Thomas Fasoulakis, Zaharias Rodolakis, Alexandros Daskalakis, Georgios Children (Basel) Review The term infertility is defined as the lack of conception within 1 year of unprotected intercourse. It affects more than 80 million individuals worldwide. It is estimated that 10-15% of couples of reproductive age are challenged by reproductive issues. Assisted reproduction techniques (ART) are responsible for more than 4% of live births. Our aim is to review the research on neurodevelopmental outcomes of newborns born after the implementation of assisted reproduction methods compared to those conceived naturally. We conducted a comprehensive search of the PubMed, Crossref and Google Scholar electronic databases for related articles up to June 2022 using the PRISMA guidelines. Our research revealed a large number of long term follow-up studies between 2 and 18 years of age, with comparable developmental outcomes. Many studies compared the effects of different infertility treatments against natural conception. The review of the literature revealed that ART is safe, as the majority of studies showed no effect on the neurodevelopmental outcomes of the offspring. In most cases when such an effect was observed, it could be attributed to confounding factors such as subfertility, multiple pregnancies and gestational age at delivery. Finally, the increase in the prevalence of neurodevelopmental disorders after ART, as described in studies with statistically significant results, is predominantly marginal, and given the low incidence of neurodevelopmental disorders in the general population, its clinical significance is debatable. MDPI 2022-10-03 /pmc/articles/PMC9600207/ /pubmed/36291447 http://dx.doi.org/10.3390/children9101511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Perros, Paraskevas Psarris, Alexandros Antsaklis, Panagiotis Theodora, Marianna Syndos, Michael Koutras, Antonios Ntounis, Thomas Fasoulakis, Zaharias Rodolakis, Alexandros Daskalakis, Georgios Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature |
title | Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature |
title_full | Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature |
title_fullStr | Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature |
title_full_unstemmed | Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature |
title_short | Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature |
title_sort | neurodevelopmental outcomes of pregnancies resulting from assisted reproduction: a review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600207/ https://www.ncbi.nlm.nih.gov/pubmed/36291447 http://dx.doi.org/10.3390/children9101511 |
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