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Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature

Few studies so far have examined the impact of nutritional status on the survival of children with cancer, with the majority of them focusing on hematological malignancies. We summarized published evidence reporting the association of nutritional status at diagnosis with overall survival (OS), event...

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Autores principales: Karalexi, Maria A., Markozannes, Georgios, Tagkas, Christos F., Katsimpris, Andreas, Tseretopoulou, Xanthippi, Tsilidis, Konstantinos K., Spector, Logan G., Schüz, Joachim, Siahanidou, Tania, Petridou, Eleni Th., Ntzani, Evangelia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600212/
https://www.ncbi.nlm.nih.gov/pubmed/36292046
http://dx.doi.org/10.3390/diagnostics12102357
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author Karalexi, Maria A.
Markozannes, Georgios
Tagkas, Christos F.
Katsimpris, Andreas
Tseretopoulou, Xanthippi
Tsilidis, Konstantinos K.
Spector, Logan G.
Schüz, Joachim
Siahanidou, Tania
Petridou, Eleni Th.
Ntzani, Evangelia E.
author_facet Karalexi, Maria A.
Markozannes, Georgios
Tagkas, Christos F.
Katsimpris, Andreas
Tseretopoulou, Xanthippi
Tsilidis, Konstantinos K.
Spector, Logan G.
Schüz, Joachim
Siahanidou, Tania
Petridou, Eleni Th.
Ntzani, Evangelia E.
author_sort Karalexi, Maria A.
collection PubMed
description Few studies so far have examined the impact of nutritional status on the survival of children with cancer, with the majority of them focusing on hematological malignancies. We summarized published evidence reporting the association of nutritional status at diagnosis with overall survival (OS), event-free survival (EFS), relapse, and treatment-related toxicity (TRT) in children with cancer. Published studies on children with leukemia, lymphoma, and other solid tumors have shown that both under-nourished and over-nourished children at cancer diagnosis had worse OS and EFS. Particularly, the risk of death and relapse increased by 30–50% among children with leukemia with increased body mass index at diagnosis. Likewise, the risk of TRT was higher among malnourished children with osteosarcoma and Ewing sarcoma. Nutritional status seems to play a crucial role in clinical outcomes of children with cancer, thus providing a significant modifiable prognostic tool in childhood cancer management. Future studies with adequate power and longitudinal design are needed to further evaluate the association of nutritional status with childhood cancer outcomes using a more standardized definition to measure nutritional status in this population. The use of new technologies is expected to shed further light on this understudied area and give room to person-targeted intervention strategies.
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spelling pubmed-96002122022-10-27 Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature Karalexi, Maria A. Markozannes, Georgios Tagkas, Christos F. Katsimpris, Andreas Tseretopoulou, Xanthippi Tsilidis, Konstantinos K. Spector, Logan G. Schüz, Joachim Siahanidou, Tania Petridou, Eleni Th. Ntzani, Evangelia E. Diagnostics (Basel) Review Few studies so far have examined the impact of nutritional status on the survival of children with cancer, with the majority of them focusing on hematological malignancies. We summarized published evidence reporting the association of nutritional status at diagnosis with overall survival (OS), event-free survival (EFS), relapse, and treatment-related toxicity (TRT) in children with cancer. Published studies on children with leukemia, lymphoma, and other solid tumors have shown that both under-nourished and over-nourished children at cancer diagnosis had worse OS and EFS. Particularly, the risk of death and relapse increased by 30–50% among children with leukemia with increased body mass index at diagnosis. Likewise, the risk of TRT was higher among malnourished children with osteosarcoma and Ewing sarcoma. Nutritional status seems to play a crucial role in clinical outcomes of children with cancer, thus providing a significant modifiable prognostic tool in childhood cancer management. Future studies with adequate power and longitudinal design are needed to further evaluate the association of nutritional status with childhood cancer outcomes using a more standardized definition to measure nutritional status in this population. The use of new technologies is expected to shed further light on this understudied area and give room to person-targeted intervention strategies. MDPI 2022-09-28 /pmc/articles/PMC9600212/ /pubmed/36292046 http://dx.doi.org/10.3390/diagnostics12102357 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Karalexi, Maria A.
Markozannes, Georgios
Tagkas, Christos F.
Katsimpris, Andreas
Tseretopoulou, Xanthippi
Tsilidis, Konstantinos K.
Spector, Logan G.
Schüz, Joachim
Siahanidou, Tania
Petridou, Eleni Th.
Ntzani, Evangelia E.
Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature
title Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature
title_full Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature
title_fullStr Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature
title_full_unstemmed Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature
title_short Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature
title_sort nutritional status at diagnosis as predictor of survival from childhood cancer: a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600212/
https://www.ncbi.nlm.nih.gov/pubmed/36292046
http://dx.doi.org/10.3390/diagnostics12102357
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