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Placenta, the Key Witness of COVID-19 Infection in Premature Births
Adverse perinatal outcomes, such as increased risks of pre-eclampsia, miscarriage, premature birth, and stillbirth have been reported in SARS-CoV-2 infection. For a better understanding of COVID-19 complications in pregnancy, histopathological changes in the placenta, which is the interface between...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600231/ https://www.ncbi.nlm.nih.gov/pubmed/36292012 http://dx.doi.org/10.3390/diagnostics12102323 |
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author | Bobei, Tina-Ioana Sima, Romina-Marina Gorecki, Gabriel-Petre Poenaru, Mircea-Octavian Olaru, Octavian-Gabriel Bobirca, Anca Cirstoveanu, Catalin Chicea, Radu Topirceanu-Andreoiu, Oana-Maria Ples, Liana |
author_facet | Bobei, Tina-Ioana Sima, Romina-Marina Gorecki, Gabriel-Petre Poenaru, Mircea-Octavian Olaru, Octavian-Gabriel Bobirca, Anca Cirstoveanu, Catalin Chicea, Radu Topirceanu-Andreoiu, Oana-Maria Ples, Liana |
author_sort | Bobei, Tina-Ioana |
collection | PubMed |
description | Adverse perinatal outcomes, such as increased risks of pre-eclampsia, miscarriage, premature birth, and stillbirth have been reported in SARS-CoV-2 infection. For a better understanding of COVID-19 complications in pregnancy, histopathological changes in the placenta, which is the interface between mother and foetus, could be the place to look at. The aim of this study was to determine placental histopathological changes and their role in preterm birth in pregnant women with SARS-CoV-2 infection. We performed a prospective, observational study in a COVID-only hospital, which included 39 pregnant women with SARS-CoV-2 infection and preterm birth compared with a control group of 39 women COVID-19 negative with preterm birth and a placental pathology exam available. The microscopic examination of all placentas revealed placental infarction (64.1% vs. 30.8%), decidual arteriopathy (66.7% vs. 23.1%), intervillous thrombi (53.8% vs. 38.5%), perivillous fibrin deposits (59% vs. 46.2%), inflammatory infiltrate (69.2% vs. 46.2%), chorangiosis (17.9% vs. 10.3%), and accelerated maturation of the villi (23.1% vs. 28.2%). |
format | Online Article Text |
id | pubmed-9600231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96002312022-10-27 Placenta, the Key Witness of COVID-19 Infection in Premature Births Bobei, Tina-Ioana Sima, Romina-Marina Gorecki, Gabriel-Petre Poenaru, Mircea-Octavian Olaru, Octavian-Gabriel Bobirca, Anca Cirstoveanu, Catalin Chicea, Radu Topirceanu-Andreoiu, Oana-Maria Ples, Liana Diagnostics (Basel) Article Adverse perinatal outcomes, such as increased risks of pre-eclampsia, miscarriage, premature birth, and stillbirth have been reported in SARS-CoV-2 infection. For a better understanding of COVID-19 complications in pregnancy, histopathological changes in the placenta, which is the interface between mother and foetus, could be the place to look at. The aim of this study was to determine placental histopathological changes and their role in preterm birth in pregnant women with SARS-CoV-2 infection. We performed a prospective, observational study in a COVID-only hospital, which included 39 pregnant women with SARS-CoV-2 infection and preterm birth compared with a control group of 39 women COVID-19 negative with preterm birth and a placental pathology exam available. The microscopic examination of all placentas revealed placental infarction (64.1% vs. 30.8%), decidual arteriopathy (66.7% vs. 23.1%), intervillous thrombi (53.8% vs. 38.5%), perivillous fibrin deposits (59% vs. 46.2%), inflammatory infiltrate (69.2% vs. 46.2%), chorangiosis (17.9% vs. 10.3%), and accelerated maturation of the villi (23.1% vs. 28.2%). MDPI 2022-09-26 /pmc/articles/PMC9600231/ /pubmed/36292012 http://dx.doi.org/10.3390/diagnostics12102323 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bobei, Tina-Ioana Sima, Romina-Marina Gorecki, Gabriel-Petre Poenaru, Mircea-Octavian Olaru, Octavian-Gabriel Bobirca, Anca Cirstoveanu, Catalin Chicea, Radu Topirceanu-Andreoiu, Oana-Maria Ples, Liana Placenta, the Key Witness of COVID-19 Infection in Premature Births |
title | Placenta, the Key Witness of COVID-19 Infection in Premature Births |
title_full | Placenta, the Key Witness of COVID-19 Infection in Premature Births |
title_fullStr | Placenta, the Key Witness of COVID-19 Infection in Premature Births |
title_full_unstemmed | Placenta, the Key Witness of COVID-19 Infection in Premature Births |
title_short | Placenta, the Key Witness of COVID-19 Infection in Premature Births |
title_sort | placenta, the key witness of covid-19 infection in premature births |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600231/ https://www.ncbi.nlm.nih.gov/pubmed/36292012 http://dx.doi.org/10.3390/diagnostics12102323 |
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