Cargando…

Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis

(1) Background: Residual breast cancer after neoadjuvant chemotherapy (NAC) could have a variable image pattern on a follow-up breast magnetic resonance image (MRI). In this study, we compared the clinical outcome of breast cancer patients with different residual tumor patterns (RTP) on a breast MRI...

Descripción completa

Detalles Bibliográficos
Autores principales: Cha, Yoon Jin, Eun, Na Lae, Kim, Dooreh, Bae, Soong June, Ahn, Sung Gwe, Jeong, Joon, Park, Woo-Chan, Lee, Yangkyu, Yoon, Chang Ik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600236/
https://www.ncbi.nlm.nih.gov/pubmed/36291984
http://dx.doi.org/10.3390/diagnostics12102294
_version_ 1784816791468376064
author Cha, Yoon Jin
Eun, Na Lae
Kim, Dooreh
Bae, Soong June
Ahn, Sung Gwe
Jeong, Joon
Park, Woo-Chan
Lee, Yangkyu
Yoon, Chang Ik
author_facet Cha, Yoon Jin
Eun, Na Lae
Kim, Dooreh
Bae, Soong June
Ahn, Sung Gwe
Jeong, Joon
Park, Woo-Chan
Lee, Yangkyu
Yoon, Chang Ik
author_sort Cha, Yoon Jin
collection PubMed
description (1) Background: Residual breast cancer after neoadjuvant chemotherapy (NAC) could have a variable image pattern on a follow-up breast magnetic resonance image (MRI). In this study, we compared the clinical outcome of breast cancer patients with different residual tumor patterns (RTP) on a breast MRI after NAC. (2) Methods: A total of 91 patients with breast cancer who received NAC and subsequent curative surgery were selected. All included patient had residual breast cancer after NAC and showed a partial response on a breast MRI. Pre- and post-treatment were reviewed by an experienced radiologist to evaluate different RTP, and classified into two groups: concentric and scattered patterns. The clinicopathologic parameters and survival outcomes [recurrence-free survival (RFS) and distant metastasis-free survival (DMFS)] were analyzed according to different RTP. (3) Results: Patients with a scattered pattern had a larger extent of pre-treated non-mass enhancement and more frequently received total mastectomy. With a median follow-up period of 37 months, RTP were not significantly associated with RFS or DMFS. (4) Conclusions: In the patients with residual breast cancer after NAC, RTP on an MRI had no effect on the patients’ clinical outcome. The curative resection of the tumor bed and securing the negative resection margins appear to be important in the treatment of patients with residual breast cancer after NAC.
format Online
Article
Text
id pubmed-9600236
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96002362022-10-27 Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis Cha, Yoon Jin Eun, Na Lae Kim, Dooreh Bae, Soong June Ahn, Sung Gwe Jeong, Joon Park, Woo-Chan Lee, Yangkyu Yoon, Chang Ik Diagnostics (Basel) Article (1) Background: Residual breast cancer after neoadjuvant chemotherapy (NAC) could have a variable image pattern on a follow-up breast magnetic resonance image (MRI). In this study, we compared the clinical outcome of breast cancer patients with different residual tumor patterns (RTP) on a breast MRI after NAC. (2) Methods: A total of 91 patients with breast cancer who received NAC and subsequent curative surgery were selected. All included patient had residual breast cancer after NAC and showed a partial response on a breast MRI. Pre- and post-treatment were reviewed by an experienced radiologist to evaluate different RTP, and classified into two groups: concentric and scattered patterns. The clinicopathologic parameters and survival outcomes [recurrence-free survival (RFS) and distant metastasis-free survival (DMFS)] were analyzed according to different RTP. (3) Results: Patients with a scattered pattern had a larger extent of pre-treated non-mass enhancement and more frequently received total mastectomy. With a median follow-up period of 37 months, RTP were not significantly associated with RFS or DMFS. (4) Conclusions: In the patients with residual breast cancer after NAC, RTP on an MRI had no effect on the patients’ clinical outcome. The curative resection of the tumor bed and securing the negative resection margins appear to be important in the treatment of patients with residual breast cancer after NAC. MDPI 2022-09-23 /pmc/articles/PMC9600236/ /pubmed/36291984 http://dx.doi.org/10.3390/diagnostics12102294 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cha, Yoon Jin
Eun, Na Lae
Kim, Dooreh
Bae, Soong June
Ahn, Sung Gwe
Jeong, Joon
Park, Woo-Chan
Lee, Yangkyu
Yoon, Chang Ik
Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis
title Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis
title_full Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis
title_fullStr Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis
title_full_unstemmed Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis
title_short Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis
title_sort residual tumor patterns of breast cancer on mri after neo-adjuvant chemotherapy: impact on clinicopathologic factors and prognosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600236/
https://www.ncbi.nlm.nih.gov/pubmed/36291984
http://dx.doi.org/10.3390/diagnostics12102294
work_keys_str_mv AT chayoonjin residualtumorpatternsofbreastcanceronmriafterneoadjuvantchemotherapyimpactonclinicopathologicfactorsandprognosis
AT eunnalae residualtumorpatternsofbreastcanceronmriafterneoadjuvantchemotherapyimpactonclinicopathologicfactorsandprognosis
AT kimdooreh residualtumorpatternsofbreastcanceronmriafterneoadjuvantchemotherapyimpactonclinicopathologicfactorsandprognosis
AT baesoongjune residualtumorpatternsofbreastcanceronmriafterneoadjuvantchemotherapyimpactonclinicopathologicfactorsandprognosis
AT ahnsunggwe residualtumorpatternsofbreastcanceronmriafterneoadjuvantchemotherapyimpactonclinicopathologicfactorsandprognosis
AT jeongjoon residualtumorpatternsofbreastcanceronmriafterneoadjuvantchemotherapyimpactonclinicopathologicfactorsandprognosis
AT parkwoochan residualtumorpatternsofbreastcanceronmriafterneoadjuvantchemotherapyimpactonclinicopathologicfactorsandprognosis
AT leeyangkyu residualtumorpatternsofbreastcanceronmriafterneoadjuvantchemotherapyimpactonclinicopathologicfactorsandprognosis
AT yoonchangik residualtumorpatternsofbreastcanceronmriafterneoadjuvantchemotherapyimpactonclinicopathologicfactorsandprognosis