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Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC)

The clinical behaviors, prognosis, and appropriate treatments of papillary tumors of the pineal region (PTPR) are not fully defined due to the rarity of these tumors. At diagnosis, PTPR may present with clinical symptoms, including headache with obstructive hydrocephalus, diplopia, vomiting, and let...

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Autores principales: Mobark, Nahla A., Alharbi, Musa, Alotabi, Fahad, Alshoumer, Azhar, Al Shakweer, Wafa, AlNaqib, Zaid G., AlSaad, Abdulaziz N., Balbaid, Ali O., Alsolme, Ebtehal, Abedalthagafi, Malak S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600283/
https://www.ncbi.nlm.nih.gov/pubmed/36290872
http://dx.doi.org/10.3390/curroncol29100595
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author Mobark, Nahla A.
Alharbi, Musa
Alotabi, Fahad
Alshoumer, Azhar
Al Shakweer, Wafa
AlNaqib, Zaid G.
AlSaad, Abdulaziz N.
Balbaid, Ali O.
Alsolme, Ebtehal
Abedalthagafi, Malak S.
author_facet Mobark, Nahla A.
Alharbi, Musa
Alotabi, Fahad
Alshoumer, Azhar
Al Shakweer, Wafa
AlNaqib, Zaid G.
AlSaad, Abdulaziz N.
Balbaid, Ali O.
Alsolme, Ebtehal
Abedalthagafi, Malak S.
author_sort Mobark, Nahla A.
collection PubMed
description The clinical behaviors, prognosis, and appropriate treatments of papillary tumors of the pineal region (PTPR) are not fully defined due to the rarity of these tumors. At diagnosis, PTPR may present with clinical symptoms, including headache with obstructive hydrocephalus, diplopia, vomiting, and lethargy, as well as neurological signs, including Argyll Robertson pupils and Parinaud’s syndrome due to compression of the dorsal midbrain, specifically the periaqueductal region with horizontal nystagmus. Radiological assessment of pineal region lesions is challenging, with a wide range of potential differential diagnoses. PTPR typically presents as a heterogeneous, well-circumscribed mass in the pineal region, which might contain cystic areas, calcifications, hemorrhages, or protein accumulations. Here, we report three female pediatric patients with PTPR treated in King Fahad Medical City (KFMC) in Saudi Arabia. Histological and immunohistochemical diagnosis was confirmed by analysis of genome-wide DNA methylation profiles. This case series expands on the available reports on the clinical presentations of PTPR and provides important information on the responses to different treatment modalities.
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spelling pubmed-96002832022-10-27 Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC) Mobark, Nahla A. Alharbi, Musa Alotabi, Fahad Alshoumer, Azhar Al Shakweer, Wafa AlNaqib, Zaid G. AlSaad, Abdulaziz N. Balbaid, Ali O. Alsolme, Ebtehal Abedalthagafi, Malak S. Curr Oncol Case Report The clinical behaviors, prognosis, and appropriate treatments of papillary tumors of the pineal region (PTPR) are not fully defined due to the rarity of these tumors. At diagnosis, PTPR may present with clinical symptoms, including headache with obstructive hydrocephalus, diplopia, vomiting, and lethargy, as well as neurological signs, including Argyll Robertson pupils and Parinaud’s syndrome due to compression of the dorsal midbrain, specifically the periaqueductal region with horizontal nystagmus. Radiological assessment of pineal region lesions is challenging, with a wide range of potential differential diagnoses. PTPR typically presents as a heterogeneous, well-circumscribed mass in the pineal region, which might contain cystic areas, calcifications, hemorrhages, or protein accumulations. Here, we report three female pediatric patients with PTPR treated in King Fahad Medical City (KFMC) in Saudi Arabia. Histological and immunohistochemical diagnosis was confirmed by analysis of genome-wide DNA methylation profiles. This case series expands on the available reports on the clinical presentations of PTPR and provides important information on the responses to different treatment modalities. MDPI 2022-10-10 /pmc/articles/PMC9600283/ /pubmed/36290872 http://dx.doi.org/10.3390/curroncol29100595 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Mobark, Nahla A.
Alharbi, Musa
Alotabi, Fahad
Alshoumer, Azhar
Al Shakweer, Wafa
AlNaqib, Zaid G.
AlSaad, Abdulaziz N.
Balbaid, Ali O.
Alsolme, Ebtehal
Abedalthagafi, Malak S.
Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC)
title Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC)
title_full Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC)
title_fullStr Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC)
title_full_unstemmed Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC)
title_short Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC)
title_sort papillary tumor of the pineal region rare pediatric cns tumor case series treated in king fahad medical city (kfmc)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600283/
https://www.ncbi.nlm.nih.gov/pubmed/36290872
http://dx.doi.org/10.3390/curroncol29100595
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