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Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy
Background: This study investigated the prognostic value of axillary lymph node (ALN) heterogeneity texture features through (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in patients with locally advanced breast cancer (LABC). Methods: We retrospectivel...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600297/ https://www.ncbi.nlm.nih.gov/pubmed/36291974 http://dx.doi.org/10.3390/diagnostics12102285 |
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author | Hwang, Jae Pil Choi, Joon Young Choi, Joon Ho Cho, Young Seok Hur, Sung Mo Kim, Zisun Lim, Cheol Wan Seo, Seongho Moon, Ji Eun Woo, Sang-Keun Park, Jung Mi |
author_facet | Hwang, Jae Pil Choi, Joon Young Choi, Joon Ho Cho, Young Seok Hur, Sung Mo Kim, Zisun Lim, Cheol Wan Seo, Seongho Moon, Ji Eun Woo, Sang-Keun Park, Jung Mi |
author_sort | Hwang, Jae Pil |
collection | PubMed |
description | Background: This study investigated the prognostic value of axillary lymph node (ALN) heterogeneity texture features through (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in patients with locally advanced breast cancer (LABC). Methods: We retrospectively analyzed 158 LABC patients with FDG-avid, pathology-proven, metastatic ALN who underwent neoadjuvant chemotherapy (NAC) and curative surgery. Tumor and ALN texture parameters were extracted from pretreatment (18)F-FDG PET/CT using Chang-Gung Image Texture Analysis software. The least absolute shrinkage and selection operator regression was performed to select the most significant predictive texture parameters. The predictive impact of texture parameters was evaluated for both progression-free survival and pathologic NAC response. Results: The median follow-up period of 36.8 months and progression of disease (PD) was observed in 36 patients. In the univariate analysis, ALN textures (minimum standardized uptake value (SUV) (p = 0.026), SUV skewness (p = 0.038), SUV bias-corrected Kurtosis (p = 0.034), total lesion glycolysis (p = 0.011)), tumor textures (low-intensity size zone emphasis (p = 0.045), minimum SUV (p = 0.047), and homogeneity (p = 0.041)) were significant texture predictors. On the Cox regression analysis, ALN SUV skewness was an independent texture predictor of PD (p = 0.016, hazard ratio 2.3, 95% confidence interval 1.16–4.58). Conclusions: ALN texture feature from pretreatment (18)F-FDG PET/CT is useful for the prediction of LABC progression. |
format | Online Article Text |
id | pubmed-9600297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96002972022-10-27 Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy Hwang, Jae Pil Choi, Joon Young Choi, Joon Ho Cho, Young Seok Hur, Sung Mo Kim, Zisun Lim, Cheol Wan Seo, Seongho Moon, Ji Eun Woo, Sang-Keun Park, Jung Mi Diagnostics (Basel) Article Background: This study investigated the prognostic value of axillary lymph node (ALN) heterogeneity texture features through (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in patients with locally advanced breast cancer (LABC). Methods: We retrospectively analyzed 158 LABC patients with FDG-avid, pathology-proven, metastatic ALN who underwent neoadjuvant chemotherapy (NAC) and curative surgery. Tumor and ALN texture parameters were extracted from pretreatment (18)F-FDG PET/CT using Chang-Gung Image Texture Analysis software. The least absolute shrinkage and selection operator regression was performed to select the most significant predictive texture parameters. The predictive impact of texture parameters was evaluated for both progression-free survival and pathologic NAC response. Results: The median follow-up period of 36.8 months and progression of disease (PD) was observed in 36 patients. In the univariate analysis, ALN textures (minimum standardized uptake value (SUV) (p = 0.026), SUV skewness (p = 0.038), SUV bias-corrected Kurtosis (p = 0.034), total lesion glycolysis (p = 0.011)), tumor textures (low-intensity size zone emphasis (p = 0.045), minimum SUV (p = 0.047), and homogeneity (p = 0.041)) were significant texture predictors. On the Cox regression analysis, ALN SUV skewness was an independent texture predictor of PD (p = 0.016, hazard ratio 2.3, 95% confidence interval 1.16–4.58). Conclusions: ALN texture feature from pretreatment (18)F-FDG PET/CT is useful for the prediction of LABC progression. MDPI 2022-09-22 /pmc/articles/PMC9600297/ /pubmed/36291974 http://dx.doi.org/10.3390/diagnostics12102285 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hwang, Jae Pil Choi, Joon Young Choi, Joon Ho Cho, Young Seok Hur, Sung Mo Kim, Zisun Lim, Cheol Wan Seo, Seongho Moon, Ji Eun Woo, Sang-Keun Park, Jung Mi Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy |
title | Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy |
title_full | Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy |
title_fullStr | Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy |
title_full_unstemmed | Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy |
title_short | Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy |
title_sort | prognostic value of axillary lymph node texture parameters measured by pretreatment (18)f-fluorodeoxyglucose positron emission tomography/computed tomography in locally advanced breast cancer with neoadjuvant chemotherapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600297/ https://www.ncbi.nlm.nih.gov/pubmed/36291974 http://dx.doi.org/10.3390/diagnostics12102285 |
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