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Nature and Clinical Outcomes of Acute Hemorrhagic Rectal Ulcer

Acute hemorrhagic rectal ulcer (AHRU) is a relatively rare disease that can lead to massive hematochezia. Although AHRU is a potentially life-threatening disease, its characteristics and clinical course are not fully understood. In this study, the clinical features were compared between AHRU and low...

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Autores principales: Takahashi, Yasutaka, Shimodaira, Yosuke, Matsuhashi, Tamotsu, Tsuji, Tsuyotoshi, Fukuda, Sho, Sugawara, Kae, Saruta, Youhei, Watanabe, Kenta, Iijima, Katsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600341/
https://www.ncbi.nlm.nih.gov/pubmed/36292176
http://dx.doi.org/10.3390/diagnostics12102487
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author Takahashi, Yasutaka
Shimodaira, Yosuke
Matsuhashi, Tamotsu
Tsuji, Tsuyotoshi
Fukuda, Sho
Sugawara, Kae
Saruta, Youhei
Watanabe, Kenta
Iijima, Katsunori
author_facet Takahashi, Yasutaka
Shimodaira, Yosuke
Matsuhashi, Tamotsu
Tsuji, Tsuyotoshi
Fukuda, Sho
Sugawara, Kae
Saruta, Youhei
Watanabe, Kenta
Iijima, Katsunori
author_sort Takahashi, Yasutaka
collection PubMed
description Acute hemorrhagic rectal ulcer (AHRU) is a relatively rare disease that can lead to massive hematochezia. Although AHRU is a potentially life-threatening disease, its characteristics and clinical course are not fully understood. In this study, the clinical features were compared between AHRU and lower gastrointestinal bleeding (LGIB) from other causes (non-AHRU). Then, risk factors for all-cause in-hospital mortality in patients with AHRU were identified. A total of 387 consecutive adult patients with LGIB who were managed at two tertiary academic hospitals in Akita prefecture in Japan were retrospectively enrolled. Subjects were divided into AHRU and non-AHRU groups according to the source of bleeding. Regression analyses were used to investigate significant associations, and the results were expressed as odds ratios (ORs) and 95% confidence intervals (CIs). AHRU was found as the bleeding source in 72 (18.6%) of the patients. In comparison to non-AHRU, having AHRU was significantly associated with in-hospital onset, age > 65 years, and systolic blood pressure < 90 mmHg. The AHRU group had a significantly higher in-hospital mortality rate in comparison to the non-AHRU group (18.0% vs. 8.3, p = 0.02), and hypoalbuminemia (<2.5 g/dL) was significantly associated with in-hospital mortality in the AHRU group (OR, 4.04; 95%CI, 1.11–14.9; p = 0.03). AHRU accounts for a substantial portion (18.6%) of LGIB in our area, where the aging rate is the highest in Japan. Since AHRU is a potentially life-threatening disease that requires urgent identification and management, further studies to identify robust risk factors associated with serious clinical outcomes are required.
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spelling pubmed-96003412022-10-27 Nature and Clinical Outcomes of Acute Hemorrhagic Rectal Ulcer Takahashi, Yasutaka Shimodaira, Yosuke Matsuhashi, Tamotsu Tsuji, Tsuyotoshi Fukuda, Sho Sugawara, Kae Saruta, Youhei Watanabe, Kenta Iijima, Katsunori Diagnostics (Basel) Article Acute hemorrhagic rectal ulcer (AHRU) is a relatively rare disease that can lead to massive hematochezia. Although AHRU is a potentially life-threatening disease, its characteristics and clinical course are not fully understood. In this study, the clinical features were compared between AHRU and lower gastrointestinal bleeding (LGIB) from other causes (non-AHRU). Then, risk factors for all-cause in-hospital mortality in patients with AHRU were identified. A total of 387 consecutive adult patients with LGIB who were managed at two tertiary academic hospitals in Akita prefecture in Japan were retrospectively enrolled. Subjects were divided into AHRU and non-AHRU groups according to the source of bleeding. Regression analyses were used to investigate significant associations, and the results were expressed as odds ratios (ORs) and 95% confidence intervals (CIs). AHRU was found as the bleeding source in 72 (18.6%) of the patients. In comparison to non-AHRU, having AHRU was significantly associated with in-hospital onset, age > 65 years, and systolic blood pressure < 90 mmHg. The AHRU group had a significantly higher in-hospital mortality rate in comparison to the non-AHRU group (18.0% vs. 8.3, p = 0.02), and hypoalbuminemia (<2.5 g/dL) was significantly associated with in-hospital mortality in the AHRU group (OR, 4.04; 95%CI, 1.11–14.9; p = 0.03). AHRU accounts for a substantial portion (18.6%) of LGIB in our area, where the aging rate is the highest in Japan. Since AHRU is a potentially life-threatening disease that requires urgent identification and management, further studies to identify robust risk factors associated with serious clinical outcomes are required. MDPI 2022-10-14 /pmc/articles/PMC9600341/ /pubmed/36292176 http://dx.doi.org/10.3390/diagnostics12102487 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Takahashi, Yasutaka
Shimodaira, Yosuke
Matsuhashi, Tamotsu
Tsuji, Tsuyotoshi
Fukuda, Sho
Sugawara, Kae
Saruta, Youhei
Watanabe, Kenta
Iijima, Katsunori
Nature and Clinical Outcomes of Acute Hemorrhagic Rectal Ulcer
title Nature and Clinical Outcomes of Acute Hemorrhagic Rectal Ulcer
title_full Nature and Clinical Outcomes of Acute Hemorrhagic Rectal Ulcer
title_fullStr Nature and Clinical Outcomes of Acute Hemorrhagic Rectal Ulcer
title_full_unstemmed Nature and Clinical Outcomes of Acute Hemorrhagic Rectal Ulcer
title_short Nature and Clinical Outcomes of Acute Hemorrhagic Rectal Ulcer
title_sort nature and clinical outcomes of acute hemorrhagic rectal ulcer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600341/
https://www.ncbi.nlm.nih.gov/pubmed/36292176
http://dx.doi.org/10.3390/diagnostics12102487
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