Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in RTA3 That is Associated with Drug Resistance

We analyzed the genomes of 170 C. parapsilosis isolates and identified multiple copy number variations (CNVs). We identified two genes, RTA3 (CPAR2_104610) and ARR3 (CPAR2_601050), each of which was the target of multiple independent amplification events. Phylogenetic analysis shows that most of the...

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Detalles Bibliográficos
Autores principales: Bergin, Sean A., Zhao, Fang, Ryan, Adam P., Müller, Carolin A., Nieduszynski, Conrad A., Zhai, Bing, Rolling, Thierry, Hohl, Tobias M., Morio, Florent, Scully, Jillian, Wolfe, Kenneth H., Butler, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600344/
https://www.ncbi.nlm.nih.gov/pubmed/36121151
http://dx.doi.org/10.1128/mbio.01777-22

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