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Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications

Anticoagulant drugs antagonize coagulation and are used to prevent or cure (recurrent) venous thromboembolism (VTE). Drugs to prevent clotting have been used for more than a century, and, nowadays, physicians possess a broad panel of multiple anticoagulants to meet the individual needs of a patient....

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Autores principales: Heestermans, Marco, Poenou, Géraldine, Hamzeh-Cognasse, Hind, Cognasse, Fabrice, Bertoletti, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600347/
https://www.ncbi.nlm.nih.gov/pubmed/36291080
http://dx.doi.org/10.3390/cells11203214
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author Heestermans, Marco
Poenou, Géraldine
Hamzeh-Cognasse, Hind
Cognasse, Fabrice
Bertoletti, Laurent
author_facet Heestermans, Marco
Poenou, Géraldine
Hamzeh-Cognasse, Hind
Cognasse, Fabrice
Bertoletti, Laurent
author_sort Heestermans, Marco
collection PubMed
description Anticoagulant drugs antagonize coagulation and are used to prevent or cure (recurrent) venous thromboembolism (VTE). Drugs to prevent clotting have been used for more than a century, and, nowadays, physicians possess a broad panel of multiple anticoagulants to meet the individual needs of a patient. Within this review, we aimed to revise the history of the different anticoagulants that are currently prescribed in the clinic. In addition, we compared their pharmacological properties, medical indications, and the difficulties in implementing new anticoagulants in vulnerable patient populations. Since the introduction of unfractionated heparin in the 1930s, major advances in the mechanistic understanding and the medical use of anticoagulants have allowed for significant improvements to treat VTE patients. However, a new generation of anticoagulants is currently being tested in clinical trials, with the goal of further optimizing medical care.
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spelling pubmed-96003472022-10-27 Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications Heestermans, Marco Poenou, Géraldine Hamzeh-Cognasse, Hind Cognasse, Fabrice Bertoletti, Laurent Cells Review Anticoagulant drugs antagonize coagulation and are used to prevent or cure (recurrent) venous thromboembolism (VTE). Drugs to prevent clotting have been used for more than a century, and, nowadays, physicians possess a broad panel of multiple anticoagulants to meet the individual needs of a patient. Within this review, we aimed to revise the history of the different anticoagulants that are currently prescribed in the clinic. In addition, we compared their pharmacological properties, medical indications, and the difficulties in implementing new anticoagulants in vulnerable patient populations. Since the introduction of unfractionated heparin in the 1930s, major advances in the mechanistic understanding and the medical use of anticoagulants have allowed for significant improvements to treat VTE patients. However, a new generation of anticoagulants is currently being tested in clinical trials, with the goal of further optimizing medical care. MDPI 2022-10-13 /pmc/articles/PMC9600347/ /pubmed/36291080 http://dx.doi.org/10.3390/cells11203214 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Heestermans, Marco
Poenou, Géraldine
Hamzeh-Cognasse, Hind
Cognasse, Fabrice
Bertoletti, Laurent
Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications
title Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications
title_full Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications
title_fullStr Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications
title_full_unstemmed Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications
title_short Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications
title_sort anticoagulants: a short history, their mechanism of action, pharmacology, and indications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600347/
https://www.ncbi.nlm.nih.gov/pubmed/36291080
http://dx.doi.org/10.3390/cells11203214
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