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Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications
Anticoagulant drugs antagonize coagulation and are used to prevent or cure (recurrent) venous thromboembolism (VTE). Drugs to prevent clotting have been used for more than a century, and, nowadays, physicians possess a broad panel of multiple anticoagulants to meet the individual needs of a patient....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600347/ https://www.ncbi.nlm.nih.gov/pubmed/36291080 http://dx.doi.org/10.3390/cells11203214 |
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author | Heestermans, Marco Poenou, Géraldine Hamzeh-Cognasse, Hind Cognasse, Fabrice Bertoletti, Laurent |
author_facet | Heestermans, Marco Poenou, Géraldine Hamzeh-Cognasse, Hind Cognasse, Fabrice Bertoletti, Laurent |
author_sort | Heestermans, Marco |
collection | PubMed |
description | Anticoagulant drugs antagonize coagulation and are used to prevent or cure (recurrent) venous thromboembolism (VTE). Drugs to prevent clotting have been used for more than a century, and, nowadays, physicians possess a broad panel of multiple anticoagulants to meet the individual needs of a patient. Within this review, we aimed to revise the history of the different anticoagulants that are currently prescribed in the clinic. In addition, we compared their pharmacological properties, medical indications, and the difficulties in implementing new anticoagulants in vulnerable patient populations. Since the introduction of unfractionated heparin in the 1930s, major advances in the mechanistic understanding and the medical use of anticoagulants have allowed for significant improvements to treat VTE patients. However, a new generation of anticoagulants is currently being tested in clinical trials, with the goal of further optimizing medical care. |
format | Online Article Text |
id | pubmed-9600347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96003472022-10-27 Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications Heestermans, Marco Poenou, Géraldine Hamzeh-Cognasse, Hind Cognasse, Fabrice Bertoletti, Laurent Cells Review Anticoagulant drugs antagonize coagulation and are used to prevent or cure (recurrent) venous thromboembolism (VTE). Drugs to prevent clotting have been used for more than a century, and, nowadays, physicians possess a broad panel of multiple anticoagulants to meet the individual needs of a patient. Within this review, we aimed to revise the history of the different anticoagulants that are currently prescribed in the clinic. In addition, we compared their pharmacological properties, medical indications, and the difficulties in implementing new anticoagulants in vulnerable patient populations. Since the introduction of unfractionated heparin in the 1930s, major advances in the mechanistic understanding and the medical use of anticoagulants have allowed for significant improvements to treat VTE patients. However, a new generation of anticoagulants is currently being tested in clinical trials, with the goal of further optimizing medical care. MDPI 2022-10-13 /pmc/articles/PMC9600347/ /pubmed/36291080 http://dx.doi.org/10.3390/cells11203214 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Heestermans, Marco Poenou, Géraldine Hamzeh-Cognasse, Hind Cognasse, Fabrice Bertoletti, Laurent Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications |
title | Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications |
title_full | Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications |
title_fullStr | Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications |
title_full_unstemmed | Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications |
title_short | Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications |
title_sort | anticoagulants: a short history, their mechanism of action, pharmacology, and indications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600347/ https://www.ncbi.nlm.nih.gov/pubmed/36291080 http://dx.doi.org/10.3390/cells11203214 |
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