Rigid Tissue Increases Cytoplasmic pYAP Expression in Pre-Malignant Stage of Lung Squamous Cell Carcinoma (SCC) In Vivo

Increased tissue rigidity is able to activate the Hippo signaling pathway, leading to YAP inactivation by phosphorylation and translocation into the cytoplasm. Accumulating evidence suggests that cytoplasmic pYAP serves as a tumor suppressor and could be a prognostic biomarker for several solid canc...

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Detalles Bibliográficos
Autores principales: Zakaria, Muhammad Asyaari, Kiew, May Chee, Rajab, Nor Fadilah, Chua, Eng Wee, Masre, Siti Fathiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600365/
https://www.ncbi.nlm.nih.gov/pubmed/36286025
http://dx.doi.org/10.3390/cimb44100310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600365/
https://www.ncbi.nlm.nih.gov/pubmed/36286025
http://dx.doi.org/10.3390/cimb44100310

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