Cargando…
The Impact of Chemosensitivity on the Outcome of Brain Metastases in Small-Cell Lung Cancer: A Retrospective Analysis
Purpose: The purpose of this study was to investigate the prognostic differences between patients with small-cell lung cancer (SCLC) with different chemosensitivity to first-line chemotherapy who developed brain metastasis (BM) as the first site of progression. Methods: Patients with a BM after firs...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600390/ https://www.ncbi.nlm.nih.gov/pubmed/36290908 http://dx.doi.org/10.3390/curroncol29100631 |
_version_ | 1784816830195433472 |
---|---|
author | Ma, Jintao Meng, Chunliu Tian, Jia Ren, Kai Jia, Huijun Yan, Meng Xu, Liming Zhao, Lujun |
author_facet | Ma, Jintao Meng, Chunliu Tian, Jia Ren, Kai Jia, Huijun Yan, Meng Xu, Liming Zhao, Lujun |
author_sort | Ma, Jintao |
collection | PubMed |
description | Purpose: The purpose of this study was to investigate the prognostic differences between patients with small-cell lung cancer (SCLC) with different chemosensitivity to first-line chemotherapy who developed brain metastasis (BM) as the first site of progression. Methods: Patients with a BM after first-line treatment in the Tianjin Cancer Hospital were retrospectively analyzed. According to the time-free interval (TFI) between the completion of first-line chemotherapy and the onset of the BM, the patients were divided into the chemo-sensitive group (TFI ≥ 90 days, n = 145) and the chemo-resistant group (TFI < 90 days, n = 97). The survival time, which was calculated from the diagnosis of the BM, was analyzed after the onset of brain metastasis (BM-OS). Survival curves were plotted using the Kaplan–Meier method, and differences between groups were compared using the log-rank test. Results: In total, the median BM-OS was 8.4 months. The median BM-OS in the chemo-sensitive group was 8.8 months, and it was 8.0 months in the chemo-resistant group (p = 0.538). In patients without extracranial progression (n = 193), the median BM-OSes in the chemo-sensitive and chemo-resistant groups were 9.4 months and 9.7 months, respectively (p = 0.947). In patients with extracranial progression (n = 49), the median BM-OSes in the chemo-sensitive and chemo-resistant groups were 5.4 months and 4.2 months, respectively (p = 0.161). Conclusions: After the development of a BM as the first site of progression following chemotherapy in patients with SCLC, the prognosis of chemo-sensitive patients was not necessarily superior to chemo-resistant patients, especially in patients without extracranial progression. |
format | Online Article Text |
id | pubmed-9600390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96003902022-10-27 The Impact of Chemosensitivity on the Outcome of Brain Metastases in Small-Cell Lung Cancer: A Retrospective Analysis Ma, Jintao Meng, Chunliu Tian, Jia Ren, Kai Jia, Huijun Yan, Meng Xu, Liming Zhao, Lujun Curr Oncol Article Purpose: The purpose of this study was to investigate the prognostic differences between patients with small-cell lung cancer (SCLC) with different chemosensitivity to first-line chemotherapy who developed brain metastasis (BM) as the first site of progression. Methods: Patients with a BM after first-line treatment in the Tianjin Cancer Hospital were retrospectively analyzed. According to the time-free interval (TFI) between the completion of first-line chemotherapy and the onset of the BM, the patients were divided into the chemo-sensitive group (TFI ≥ 90 days, n = 145) and the chemo-resistant group (TFI < 90 days, n = 97). The survival time, which was calculated from the diagnosis of the BM, was analyzed after the onset of brain metastasis (BM-OS). Survival curves were plotted using the Kaplan–Meier method, and differences between groups were compared using the log-rank test. Results: In total, the median BM-OS was 8.4 months. The median BM-OS in the chemo-sensitive group was 8.8 months, and it was 8.0 months in the chemo-resistant group (p = 0.538). In patients without extracranial progression (n = 193), the median BM-OSes in the chemo-sensitive and chemo-resistant groups were 9.4 months and 9.7 months, respectively (p = 0.947). In patients with extracranial progression (n = 49), the median BM-OSes in the chemo-sensitive and chemo-resistant groups were 5.4 months and 4.2 months, respectively (p = 0.161). Conclusions: After the development of a BM as the first site of progression following chemotherapy in patients with SCLC, the prognosis of chemo-sensitive patients was not necessarily superior to chemo-resistant patients, especially in patients without extracranial progression. MDPI 2022-10-21 /pmc/articles/PMC9600390/ /pubmed/36290908 http://dx.doi.org/10.3390/curroncol29100631 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ma, Jintao Meng, Chunliu Tian, Jia Ren, Kai Jia, Huijun Yan, Meng Xu, Liming Zhao, Lujun The Impact of Chemosensitivity on the Outcome of Brain Metastases in Small-Cell Lung Cancer: A Retrospective Analysis |
title | The Impact of Chemosensitivity on the Outcome of Brain Metastases in Small-Cell Lung Cancer: A Retrospective Analysis |
title_full | The Impact of Chemosensitivity on the Outcome of Brain Metastases in Small-Cell Lung Cancer: A Retrospective Analysis |
title_fullStr | The Impact of Chemosensitivity on the Outcome of Brain Metastases in Small-Cell Lung Cancer: A Retrospective Analysis |
title_full_unstemmed | The Impact of Chemosensitivity on the Outcome of Brain Metastases in Small-Cell Lung Cancer: A Retrospective Analysis |
title_short | The Impact of Chemosensitivity on the Outcome of Brain Metastases in Small-Cell Lung Cancer: A Retrospective Analysis |
title_sort | impact of chemosensitivity on the outcome of brain metastases in small-cell lung cancer: a retrospective analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600390/ https://www.ncbi.nlm.nih.gov/pubmed/36290908 http://dx.doi.org/10.3390/curroncol29100631 |
work_keys_str_mv | AT majintao theimpactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT mengchunliu theimpactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT tianjia theimpactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT renkai theimpactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT jiahuijun theimpactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT yanmeng theimpactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT xuliming theimpactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT zhaolujun theimpactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT majintao impactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT mengchunliu impactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT tianjia impactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT renkai impactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT jiahuijun impactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT yanmeng impactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT xuliming impactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis AT zhaolujun impactofchemosensitivityontheoutcomeofbrainmetastasesinsmallcelllungcanceraretrospectiveanalysis |