Time after Synthesis and Time after Injection Do Not Affect Diagnostic Quality of [(18)F]F-PSMA 1007 PET

SIMPLE SUMMARY: The total number of PSMA-PET-CT examinations for the staging of prostate cancer patients has increased in recent years, following its superior imaging properties. Fluorinated PSMA ligands can be produced in larger amounts, facilitating higher patient throughput compared to the initially developed gallium labelled PSMA-tracers; allowing PET in only a few patients per synthesis. This results in a longer time after, typically early morning, radiochemical synthesis (TaS) of [(18)]F-PSMA when the PSMA-PET scan is performed. Moreover, novel fluorinated-PSMA compounds are injected around two hours before PET-CT and the time after injection (TaI) might show significant deviation. [18F]-PSMA PET offers improved detection rates in the proximity of the urinary tract; however, it has the disadvantage of more unspecific uptake, e.g., in the skeleton. This article focusses on the question whether TaS or TaI have an influence on uptake patterns in malignant lesions and healthy tissue. ABSTRACT: PET imaging using PSMA ligands is increasingly used for staging in prostate cancer patients in different clinical indications. Unlike [(68)Ga]Ga-labeled PSMA ligands, fluorinated compounds can be produced in large amounts; thus, they can be used for a higher number of patients. One concern is that in patients studied a long time after synthesis (TaS) or time after injection (TaI), the specific activity may decline; thus, the signal may be lower in these patients. In this study, we investigated a potential effect of TaS and TaI on image quality. In total, 134 consecutive patients were included in this retrospective analysis on the effect of TaS and TaI on uptake in prostate cancer lesions. All the patients underwent [(18)F]F-PSMA-1007 PET-CT from 99 min up to 549 min after tracer quality control. TaS and TaI were compared to the quantitative tumoral uptake parameters SUVmax and SUVpeak. In a second exploratory part of the analysis, TaS and TaI were correlated to a physiological tracer uptake in different organs. TaS and TaI did not affect the SUVmax and SUVpeak in tumor lesions in [(18)F]F-PSMA-1007 PET. The physiological uptake in salivary glands, lacrimal glands and the ganglia, spleen and urine was not significantly correlated to TaS or TaI; in contrast to the mean liver uptake, showing a weak, but significant correlation to TaS. The [(18)F]F-PSMA-1007 uptake in prostate cancer lesions is not significantly dependent on the TaS and TaI. These results are extremely reassuring when performing [(18)F]F-PSMA-1007 PET a considerable time after synthesis.