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MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review

Major Depressive Disorder (MDD) is a highly prevalent multifactorial psychopathology affected by neurotransmitter levels. Monoamine Oxidase A (MAOA) influences several neural pathways by modulating these levels. This systematic review (per PRISMA protocol and PECOS strategy) endeavors to understand...

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Autores principales: Castro Gonçalves, Ana Beatriz, Ferreira Fratelli, Caroline, Saraiva Siqueira, Jhon Willatan, Canongia de Abreu Cardoso Duarte, Ligia, Ribeiro Barros, Aline, Possatti, Isabella, Lima dos Santos, Maurício, de Souza Silva, Calliandra Maria, Rodrigues da Silva, Izabel Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600429/
https://www.ncbi.nlm.nih.gov/pubmed/36291132
http://dx.doi.org/10.3390/cells11203267
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author Castro Gonçalves, Ana Beatriz
Ferreira Fratelli, Caroline
Saraiva Siqueira, Jhon Willatan
Canongia de Abreu Cardoso Duarte, Ligia
Ribeiro Barros, Aline
Possatti, Isabella
Lima dos Santos, Maurício
de Souza Silva, Calliandra Maria
Rodrigues da Silva, Izabel Cristina
author_facet Castro Gonçalves, Ana Beatriz
Ferreira Fratelli, Caroline
Saraiva Siqueira, Jhon Willatan
Canongia de Abreu Cardoso Duarte, Ligia
Ribeiro Barros, Aline
Possatti, Isabella
Lima dos Santos, Maurício
de Souza Silva, Calliandra Maria
Rodrigues da Silva, Izabel Cristina
author_sort Castro Gonçalves, Ana Beatriz
collection PubMed
description Major Depressive Disorder (MDD) is a highly prevalent multifactorial psychopathology affected by neurotransmitter levels. Monoamine Oxidase A (MAOA) influences several neural pathways by modulating these levels. This systematic review (per PRISMA protocol and PECOS strategy) endeavors to understand the MAOA uVNTR polymorphism influence on MDD and evaluate its 3R/3R and 3R* genotypic frequencies fluctuation in MDD patients from different populations. We searched the Web of Science, PubMed, Virtual Health Library, and EMBASE databases for eligible original articles that brought data on genotypic frequencies related to the MAOA uVNTR variant in patients with MDD. We excluded studies with incomplete data (including statistical data), reviews, meta-analyses, and abstracts. Initially, we found 43 articles. After removing duplicates and applying the inclusion/exclusion criteria, seven articles remained. The population samples studied were predominantly Asians, with high 3R and 4R allele frequencies. Notably, we observed higher 3R/3R (female) and 3R* (male) genotype frequencies in the healthy control groups and higher 4R/4R (female) and 4R* (male) genotype frequencies in the MDD groups in the majority of different populations. Despite some similarities in the articles analyzed, there is still no consensus on the MAOA uVNTR variant’s role in MDD pathogenesis.
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spelling pubmed-96004292022-10-27 MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review Castro Gonçalves, Ana Beatriz Ferreira Fratelli, Caroline Saraiva Siqueira, Jhon Willatan Canongia de Abreu Cardoso Duarte, Ligia Ribeiro Barros, Aline Possatti, Isabella Lima dos Santos, Maurício de Souza Silva, Calliandra Maria Rodrigues da Silva, Izabel Cristina Cells Review Major Depressive Disorder (MDD) is a highly prevalent multifactorial psychopathology affected by neurotransmitter levels. Monoamine Oxidase A (MAOA) influences several neural pathways by modulating these levels. This systematic review (per PRISMA protocol and PECOS strategy) endeavors to understand the MAOA uVNTR polymorphism influence on MDD and evaluate its 3R/3R and 3R* genotypic frequencies fluctuation in MDD patients from different populations. We searched the Web of Science, PubMed, Virtual Health Library, and EMBASE databases for eligible original articles that brought data on genotypic frequencies related to the MAOA uVNTR variant in patients with MDD. We excluded studies with incomplete data (including statistical data), reviews, meta-analyses, and abstracts. Initially, we found 43 articles. After removing duplicates and applying the inclusion/exclusion criteria, seven articles remained. The population samples studied were predominantly Asians, with high 3R and 4R allele frequencies. Notably, we observed higher 3R/3R (female) and 3R* (male) genotype frequencies in the healthy control groups and higher 4R/4R (female) and 4R* (male) genotype frequencies in the MDD groups in the majority of different populations. Despite some similarities in the articles analyzed, there is still no consensus on the MAOA uVNTR variant’s role in MDD pathogenesis. MDPI 2022-10-17 /pmc/articles/PMC9600429/ /pubmed/36291132 http://dx.doi.org/10.3390/cells11203267 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Castro Gonçalves, Ana Beatriz
Ferreira Fratelli, Caroline
Saraiva Siqueira, Jhon Willatan
Canongia de Abreu Cardoso Duarte, Ligia
Ribeiro Barros, Aline
Possatti, Isabella
Lima dos Santos, Maurício
de Souza Silva, Calliandra Maria
Rodrigues da Silva, Izabel Cristina
MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review
title MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review
title_full MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review
title_fullStr MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review
title_full_unstemmed MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review
title_short MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review
title_sort maoa uvntr genetic variant and major depressive disorder: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600429/
https://www.ncbi.nlm.nih.gov/pubmed/36291132
http://dx.doi.org/10.3390/cells11203267
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