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Complications and Risk Factors in En Bloc Resection of Spinal Tumors: A Retrospective Analysis on 298 Patients Treated in a Single Institution
En bloc resection consists in the surgical removal of a vertebral tumor in a single piece with a sufficient margin, to improve survival and reduce recurrence rate. This procedure is technically demanding and correlates with a high complication rate. The purpose of this study is to investigate the ri...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600441/ https://www.ncbi.nlm.nih.gov/pubmed/36290897 http://dx.doi.org/10.3390/curroncol29100620 |
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author | Bandiera, Stefano Noli, Luigi Emanuele Griffoni, Cristiana Tosini, Giovanni Carretta, Elisa Pasini, Stefano Pesce, Eleonora Ruinato, Alfio Damiano Barbanti Brodano, Giovanni Tedesco, Giuseppe Girolami, Marco Terzi, Silvia Ghermandi, Riccardo Evangelisti, Gisberto Pipola, Valerio Gasbarrini, Alessandro |
author_facet | Bandiera, Stefano Noli, Luigi Emanuele Griffoni, Cristiana Tosini, Giovanni Carretta, Elisa Pasini, Stefano Pesce, Eleonora Ruinato, Alfio Damiano Barbanti Brodano, Giovanni Tedesco, Giuseppe Girolami, Marco Terzi, Silvia Ghermandi, Riccardo Evangelisti, Gisberto Pipola, Valerio Gasbarrini, Alessandro |
author_sort | Bandiera, Stefano |
collection | PubMed |
description | En bloc resection consists in the surgical removal of a vertebral tumor in a single piece with a sufficient margin, to improve survival and reduce recurrence rate. This procedure is technically demanding and correlates with a high complication rate. The purpose of this study is to investigate the risk factors for complications in en bloc resection and evaluate if benefits overcome the risks in term of overall survival. We retrospectively analyzed prospectively collected data of patients treated with en bloc resection between 1980 and 2021. Complications were classified according to SAVES-V2. Overall Survival was estimated using Kaplan-Meier method. A total of 149 patients out of 298 (50%) suffered from at least one complication. Moreover, 220 adverse events were collected (67 intraoperative, 82 early post-operative, 71 late post-operative), 54% of these were classified as grade 3 (in a severity scale from 1 to 6). Ten years overall survival was 67% (95% CI 59–74). The occurrence of relapses was associated to an increased risk of mortality with OR 3.4 (95% CI 2.1–5.5), while complications did not affect the overall survival. Despite a high complication rate, en bloc resection allows for a better control of disease and should be performed in selected patients by specialized surgeons. |
format | Online Article Text |
id | pubmed-9600441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96004412022-10-27 Complications and Risk Factors in En Bloc Resection of Spinal Tumors: A Retrospective Analysis on 298 Patients Treated in a Single Institution Bandiera, Stefano Noli, Luigi Emanuele Griffoni, Cristiana Tosini, Giovanni Carretta, Elisa Pasini, Stefano Pesce, Eleonora Ruinato, Alfio Damiano Barbanti Brodano, Giovanni Tedesco, Giuseppe Girolami, Marco Terzi, Silvia Ghermandi, Riccardo Evangelisti, Gisberto Pipola, Valerio Gasbarrini, Alessandro Curr Oncol Article En bloc resection consists in the surgical removal of a vertebral tumor in a single piece with a sufficient margin, to improve survival and reduce recurrence rate. This procedure is technically demanding and correlates with a high complication rate. The purpose of this study is to investigate the risk factors for complications in en bloc resection and evaluate if benefits overcome the risks in term of overall survival. We retrospectively analyzed prospectively collected data of patients treated with en bloc resection between 1980 and 2021. Complications were classified according to SAVES-V2. Overall Survival was estimated using Kaplan-Meier method. A total of 149 patients out of 298 (50%) suffered from at least one complication. Moreover, 220 adverse events were collected (67 intraoperative, 82 early post-operative, 71 late post-operative), 54% of these were classified as grade 3 (in a severity scale from 1 to 6). Ten years overall survival was 67% (95% CI 59–74). The occurrence of relapses was associated to an increased risk of mortality with OR 3.4 (95% CI 2.1–5.5), while complications did not affect the overall survival. Despite a high complication rate, en bloc resection allows for a better control of disease and should be performed in selected patients by specialized surgeons. MDPI 2022-10-17 /pmc/articles/PMC9600441/ /pubmed/36290897 http://dx.doi.org/10.3390/curroncol29100620 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bandiera, Stefano Noli, Luigi Emanuele Griffoni, Cristiana Tosini, Giovanni Carretta, Elisa Pasini, Stefano Pesce, Eleonora Ruinato, Alfio Damiano Barbanti Brodano, Giovanni Tedesco, Giuseppe Girolami, Marco Terzi, Silvia Ghermandi, Riccardo Evangelisti, Gisberto Pipola, Valerio Gasbarrini, Alessandro Complications and Risk Factors in En Bloc Resection of Spinal Tumors: A Retrospective Analysis on 298 Patients Treated in a Single Institution |
title | Complications and Risk Factors in En Bloc Resection of Spinal Tumors: A Retrospective Analysis on 298 Patients Treated in a Single Institution |
title_full | Complications and Risk Factors in En Bloc Resection of Spinal Tumors: A Retrospective Analysis on 298 Patients Treated in a Single Institution |
title_fullStr | Complications and Risk Factors in En Bloc Resection of Spinal Tumors: A Retrospective Analysis on 298 Patients Treated in a Single Institution |
title_full_unstemmed | Complications and Risk Factors in En Bloc Resection of Spinal Tumors: A Retrospective Analysis on 298 Patients Treated in a Single Institution |
title_short | Complications and Risk Factors in En Bloc Resection of Spinal Tumors: A Retrospective Analysis on 298 Patients Treated in a Single Institution |
title_sort | complications and risk factors in en bloc resection of spinal tumors: a retrospective analysis on 298 patients treated in a single institution |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600441/ https://www.ncbi.nlm.nih.gov/pubmed/36290897 http://dx.doi.org/10.3390/curroncol29100620 |
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