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Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis

Ultrasound (US) is a highly sensitive imaging tool in the detection of renal masses. However, the detection rate of small renal masses (SRMs) (<4 cm) is still limited. In this scenario, contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly utilized, diagnostic modality which...

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Autores principales: Tufano, Antonio, Antonelli, Luca, Di Pierro, Giovanni Battista, Flammia, Rocco Simone, Minelli, Rocco, Anceschi, Umberto, Leonardo, Costantino, Franco, Giorgio, Drudi, Francesco Maria, Cantisani, Vito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600471/
https://www.ncbi.nlm.nih.gov/pubmed/36291999
http://dx.doi.org/10.3390/diagnostics12102310
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author Tufano, Antonio
Antonelli, Luca
Di Pierro, Giovanni Battista
Flammia, Rocco Simone
Minelli, Rocco
Anceschi, Umberto
Leonardo, Costantino
Franco, Giorgio
Drudi, Francesco Maria
Cantisani, Vito
author_facet Tufano, Antonio
Antonelli, Luca
Di Pierro, Giovanni Battista
Flammia, Rocco Simone
Minelli, Rocco
Anceschi, Umberto
Leonardo, Costantino
Franco, Giorgio
Drudi, Francesco Maria
Cantisani, Vito
author_sort Tufano, Antonio
collection PubMed
description Ultrasound (US) is a highly sensitive imaging tool in the detection of renal masses. However, the detection rate of small renal masses (SRMs) (<4 cm) is still limited. In this scenario, contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly utilized, diagnostic modality which aims to increase the overall diagnostic ability in the identification of SRMs. In consequence, we performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of CEUS in the evaluation of SRMs confirmed by pathology. A SR up to April 2022 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The diagnostic performance of CEUS was evaluated basing on malignant vs. benign SMRs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled, and summary receiver operating characteristic (SROC) curves were constructed for each endpoint. Overall, five qualified studies were deemed suitable for this meta-analysis. Finally, diagnostic performance of CEUS showed an accuracy of 0.93 in detecting malignant masses (sensitivity of 0.94, PPV of 0.95, specificity of 0.78, and NPV of 0.73). Taken together, CEUS may represent a promising minimally invasive diagnostic tool for characterization of SMRs, since it allows clinicians to identify malignant lesions.
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spelling pubmed-96004712022-10-27 Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis Tufano, Antonio Antonelli, Luca Di Pierro, Giovanni Battista Flammia, Rocco Simone Minelli, Rocco Anceschi, Umberto Leonardo, Costantino Franco, Giorgio Drudi, Francesco Maria Cantisani, Vito Diagnostics (Basel) Systematic Review Ultrasound (US) is a highly sensitive imaging tool in the detection of renal masses. However, the detection rate of small renal masses (SRMs) (<4 cm) is still limited. In this scenario, contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly utilized, diagnostic modality which aims to increase the overall diagnostic ability in the identification of SRMs. In consequence, we performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of CEUS in the evaluation of SRMs confirmed by pathology. A SR up to April 2022 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The diagnostic performance of CEUS was evaluated basing on malignant vs. benign SMRs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled, and summary receiver operating characteristic (SROC) curves were constructed for each endpoint. Overall, five qualified studies were deemed suitable for this meta-analysis. Finally, diagnostic performance of CEUS showed an accuracy of 0.93 in detecting malignant masses (sensitivity of 0.94, PPV of 0.95, specificity of 0.78, and NPV of 0.73). Taken together, CEUS may represent a promising minimally invasive diagnostic tool for characterization of SMRs, since it allows clinicians to identify malignant lesions. MDPI 2022-09-25 /pmc/articles/PMC9600471/ /pubmed/36291999 http://dx.doi.org/10.3390/diagnostics12102310 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Tufano, Antonio
Antonelli, Luca
Di Pierro, Giovanni Battista
Flammia, Rocco Simone
Minelli, Rocco
Anceschi, Umberto
Leonardo, Costantino
Franco, Giorgio
Drudi, Francesco Maria
Cantisani, Vito
Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis
title Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis
title_full Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis
title_fullStr Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis
title_full_unstemmed Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis
title_short Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis
title_sort diagnostic performance of contrast-enhanced ultrasound in the evaluation of small renal masses: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600471/
https://www.ncbi.nlm.nih.gov/pubmed/36291999
http://dx.doi.org/10.3390/diagnostics12102310
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