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Decreased FOXO1 Expression Is Correlated with Poor Prognosis in Myelodysplastic Syndromes

Myelodysplastic syndrome is one of the main hematological malignancies that threaten the health of the elderly. However, biomarkers which predict the progression and prognosis of MDS are still controversial and puzzling. FOXO1 gene plays an important role in a variety of intracellular functions, inc...

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Autores principales: Zhang, Zheng, Huang, Nanfang, Xv, Feng, Zhao, Sida, Guo, Juan, Zhao, Youshan, Chang, Chunkang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600488/
https://www.ncbi.nlm.nih.gov/pubmed/36290822
http://dx.doi.org/10.3390/curroncol29100545
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author Zhang, Zheng
Huang, Nanfang
Xv, Feng
Zhao, Sida
Guo, Juan
Zhao, Youshan
Chang, Chunkang
author_facet Zhang, Zheng
Huang, Nanfang
Xv, Feng
Zhao, Sida
Guo, Juan
Zhao, Youshan
Chang, Chunkang
author_sort Zhang, Zheng
collection PubMed
description Myelodysplastic syndrome is one of the main hematological malignancies that threaten the health of the elderly. However, biomarkers which predict the progression and prognosis of MDS are still controversial and puzzling. FOXO1 gene plays an important role in a variety of intracellular functions, including tumor suppression and cellular immune regulation. However, there is no research report on the correlation between FOXO1 and the clinical features of MDS including immune environment. In this study, we observed that FOXO1 expression is associated with neutrophil count, blasts, chromosome and different MDS scoring systems. FOXO1 expression is closely related to MDS cell immune polarization, and the increase expression of FOXO1 is significantly related to the amplification of immune cell polarization ratio. In addition, FOXO1 expression is associated with progression-free survival and overall survival in MDS patients. Moreover, in a multivariate model FOXO1 low-expression was an independent predictor of poor survival in MDS. In summary, FOXO1 may play a candidate tumor suppressor in MDS, and FOXO1 is a useful independent prognostic predictor in MDS, and it may provide a candidate target therapy in future.
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spelling pubmed-96004882022-10-27 Decreased FOXO1 Expression Is Correlated with Poor Prognosis in Myelodysplastic Syndromes Zhang, Zheng Huang, Nanfang Xv, Feng Zhao, Sida Guo, Juan Zhao, Youshan Chang, Chunkang Curr Oncol Article Myelodysplastic syndrome is one of the main hematological malignancies that threaten the health of the elderly. However, biomarkers which predict the progression and prognosis of MDS are still controversial and puzzling. FOXO1 gene plays an important role in a variety of intracellular functions, including tumor suppression and cellular immune regulation. However, there is no research report on the correlation between FOXO1 and the clinical features of MDS including immune environment. In this study, we observed that FOXO1 expression is associated with neutrophil count, blasts, chromosome and different MDS scoring systems. FOXO1 expression is closely related to MDS cell immune polarization, and the increase expression of FOXO1 is significantly related to the amplification of immune cell polarization ratio. In addition, FOXO1 expression is associated with progression-free survival and overall survival in MDS patients. Moreover, in a multivariate model FOXO1 low-expression was an independent predictor of poor survival in MDS. In summary, FOXO1 may play a candidate tumor suppressor in MDS, and FOXO1 is a useful independent prognostic predictor in MDS, and it may provide a candidate target therapy in future. MDPI 2022-09-25 /pmc/articles/PMC9600488/ /pubmed/36290822 http://dx.doi.org/10.3390/curroncol29100545 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Zheng
Huang, Nanfang
Xv, Feng
Zhao, Sida
Guo, Juan
Zhao, Youshan
Chang, Chunkang
Decreased FOXO1 Expression Is Correlated with Poor Prognosis in Myelodysplastic Syndromes
title Decreased FOXO1 Expression Is Correlated with Poor Prognosis in Myelodysplastic Syndromes
title_full Decreased FOXO1 Expression Is Correlated with Poor Prognosis in Myelodysplastic Syndromes
title_fullStr Decreased FOXO1 Expression Is Correlated with Poor Prognosis in Myelodysplastic Syndromes
title_full_unstemmed Decreased FOXO1 Expression Is Correlated with Poor Prognosis in Myelodysplastic Syndromes
title_short Decreased FOXO1 Expression Is Correlated with Poor Prognosis in Myelodysplastic Syndromes
title_sort decreased foxo1 expression is correlated with poor prognosis in myelodysplastic syndromes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600488/
https://www.ncbi.nlm.nih.gov/pubmed/36290822
http://dx.doi.org/10.3390/curroncol29100545
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