Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. An...

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Autores principales: Lin, Tien-Huang, Chang, Sunny Li-Yun, Khanh, Pham Minh, Trang, Nguyen Thi Nha, Liu, Shan-Chi, Tsai, Hsiao-Chi, Chang, An-Chen, Lin, Jo-Yu, Chen, Po-Chun, Liu, Ju-Fang, Guo, Jeng-Hung, Liu, Chun-Lin, Wu, Hsi-Chin, Tang, Chih-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600532/
https://www.ncbi.nlm.nih.gov/pubmed/36291151
http://dx.doi.org/10.3390/cells11203285
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author Lin, Tien-Huang
Chang, Sunny Li-Yun
Khanh, Pham Minh
Trang, Nguyen Thi Nha
Liu, Shan-Chi
Tsai, Hsiao-Chi
Chang, An-Chen
Lin, Jo-Yu
Chen, Po-Chun
Liu, Ju-Fang
Guo, Jeng-Hung
Liu, Chun-Lin
Wu, Hsi-Chin
Tang, Chih-Hsin
author_facet Lin, Tien-Huang
Chang, Sunny Li-Yun
Khanh, Pham Minh
Trang, Nguyen Thi Nha
Liu, Shan-Chi
Tsai, Hsiao-Chi
Chang, An-Chen
Lin, Jo-Yu
Chen, Po-Chun
Liu, Ju-Fang
Guo, Jeng-Hung
Liu, Chun-Lin
Wu, Hsi-Chin
Tang, Chih-Hsin
author_sort Lin, Tien-Huang
collection PubMed
description Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer.
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spelling pubmed-96005322022-10-27 Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression Lin, Tien-Huang Chang, Sunny Li-Yun Khanh, Pham Minh Trang, Nguyen Thi Nha Liu, Shan-Chi Tsai, Hsiao-Chi Chang, An-Chen Lin, Jo-Yu Chen, Po-Chun Liu, Ju-Fang Guo, Jeng-Hung Liu, Chun-Lin Wu, Hsi-Chin Tang, Chih-Hsin Cells Article Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis. However, the effects of apelin in prostate cancer metastasis is undetermined. Analysis of the database revealed a positive correlation between apelin level with the progression and metastasis of prostate cancer patients. Apelin treatment facilitates cell migration and invasion through inhibiting tissue inhibitor of metalloproteinase 2 (TIMP2) expression. The increasing miR-106a-5p synthesis via c-Src/PI3K/Akt signaling pathway is controlled in apelin-regulated TIMP2 production and cell motility. Importantly, apelin blockade inhibits prostate cancer metastasis in the orthotopic mouse model. Thus, apelin is a promising therapeutic target for curing metastatic prostate cancer. MDPI 2022-10-19 /pmc/articles/PMC9600532/ /pubmed/36291151 http://dx.doi.org/10.3390/cells11203285 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Tien-Huang
Chang, Sunny Li-Yun
Khanh, Pham Minh
Trang, Nguyen Thi Nha
Liu, Shan-Chi
Tsai, Hsiao-Chi
Chang, An-Chen
Lin, Jo-Yu
Chen, Po-Chun
Liu, Ju-Fang
Guo, Jeng-Hung
Liu, Chun-Lin
Wu, Hsi-Chin
Tang, Chih-Hsin
Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression
title Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression
title_full Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression
title_fullStr Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression
title_full_unstemmed Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression
title_short Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression
title_sort apelin promotes prostate cancer metastasis by downregulating timp2 via increases in mir-106a-5p expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600532/
https://www.ncbi.nlm.nih.gov/pubmed/36291151
http://dx.doi.org/10.3390/cells11203285
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