Factors That Affect the Formation of Chromosomal Translocations in Cells

SIMPLE SUMMARY: Chromosomal translocations are products of the erroneous repair of DNA double-strand breaks that result in the illegitimate joining of the two broken chromosomal ends from non-homologous chromosomes. Chromosomal translocations have been linked to aneuploidy, infertility, mental retardation, cancer and other diseases. Here we discuss how chromosomal translocations are formed and explore how different cellular factors contribute to their formation. ABSTRACT: Chromosomal translocations are products of the illegitimate repair of DNA double-strand breaks (DSBs). Their formation can bring about significant structural and molecular changes in the cell that can be physiologically and pathologically relevant. The induced changes may lead to serious and life-threatening diseases such as cancer. As a growing body of evidence suggests, the formation of chromosomal translocation is not only affected by the mere close spatial proximity of gene loci as potential translocation partners. Several factors may affect formation of chromosomal translocations, including chromatin motion to the potential sources of DSBs in the cell. While these can be apparently random events, certain chromosomal translocations appear to be cell-type-specific. In this review, we discuss how chromosomal translocations are formed and explore how different cellular factors contribute to their formation.