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Emerging Systemic Therapies in Advanced Unresectable Biliary Tract Cancer: Review and Canadian Perspective †
Biliary tract cancer (BTC) is a group of rare and aggressive malignancies with a dismal prognosis. There is currently a significant lack in effective treatment options for BTC, with gemcitabine-cisplatin remaining the first-line standard of care treatment for over a decade. A wave of investigational...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600578/ https://www.ncbi.nlm.nih.gov/pubmed/36290832 http://dx.doi.org/10.3390/curroncol29100555 |
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author | Tam, Vincent C. Ramjeesingh, Ravi Burkes, Ronald Yoshida, Eric M. Doucette, Sarah Lim, Howard J. |
author_facet | Tam, Vincent C. Ramjeesingh, Ravi Burkes, Ronald Yoshida, Eric M. Doucette, Sarah Lim, Howard J. |
author_sort | Tam, Vincent C. |
collection | PubMed |
description | Biliary tract cancer (BTC) is a group of rare and aggressive malignancies with a dismal prognosis. There is currently a significant lack in effective treatment options for BTC, with gemcitabine-cisplatin remaining the first-line standard of care treatment for over a decade. A wave of investigational therapies, including new chemotherapy combinations, immunotherapy, and biomarker-driven targeted therapy have demonstrated promising results in BTC, and there is hope for many of these therapies to be incorporated into the Canadian treatment landscape in the near future. This review discusses the emerging therapies under investigation for BTC and provides a perspective on how they may fit into Canadian practice, with a focus on the barriers to treatment access. |
format | Online Article Text |
id | pubmed-9600578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96005782022-10-27 Emerging Systemic Therapies in Advanced Unresectable Biliary Tract Cancer: Review and Canadian Perspective † Tam, Vincent C. Ramjeesingh, Ravi Burkes, Ronald Yoshida, Eric M. Doucette, Sarah Lim, Howard J. Curr Oncol Perspective Biliary tract cancer (BTC) is a group of rare and aggressive malignancies with a dismal prognosis. There is currently a significant lack in effective treatment options for BTC, with gemcitabine-cisplatin remaining the first-line standard of care treatment for over a decade. A wave of investigational therapies, including new chemotherapy combinations, immunotherapy, and biomarker-driven targeted therapy have demonstrated promising results in BTC, and there is hope for many of these therapies to be incorporated into the Canadian treatment landscape in the near future. This review discusses the emerging therapies under investigation for BTC and provides a perspective on how they may fit into Canadian practice, with a focus on the barriers to treatment access. MDPI 2022-09-28 /pmc/articles/PMC9600578/ /pubmed/36290832 http://dx.doi.org/10.3390/curroncol29100555 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Tam, Vincent C. Ramjeesingh, Ravi Burkes, Ronald Yoshida, Eric M. Doucette, Sarah Lim, Howard J. Emerging Systemic Therapies in Advanced Unresectable Biliary Tract Cancer: Review and Canadian Perspective † |
title | Emerging Systemic Therapies in Advanced Unresectable Biliary Tract Cancer: Review and Canadian Perspective † |
title_full | Emerging Systemic Therapies in Advanced Unresectable Biliary Tract Cancer: Review and Canadian Perspective † |
title_fullStr | Emerging Systemic Therapies in Advanced Unresectable Biliary Tract Cancer: Review and Canadian Perspective † |
title_full_unstemmed | Emerging Systemic Therapies in Advanced Unresectable Biliary Tract Cancer: Review and Canadian Perspective † |
title_short | Emerging Systemic Therapies in Advanced Unresectable Biliary Tract Cancer: Review and Canadian Perspective † |
title_sort | emerging systemic therapies in advanced unresectable biliary tract cancer: review and canadian perspective † |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600578/ https://www.ncbi.nlm.nih.gov/pubmed/36290832 http://dx.doi.org/10.3390/curroncol29100555 |
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