The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection

Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation, as well as longer “polyprenyl” diphosphates, used in ubiquinone and...

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Detalles Bibliográficos
Autores principales: Sleda, Melissa A., Li, Zhu-Hong, Behera, Ranjan, Baierna, Baihetiya, Li, Catherine, Jumpathong, Jomkwan, Malwal, Satish R., Kawamukai, Makoto, Oldfield, Eric, Moreno, Silvia N. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600589/
https://www.ncbi.nlm.nih.gov/pubmed/36129297
http://dx.doi.org/10.1128/mbio.01966-22

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