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Cancer Patients First Treated with Chemotherapy: Are They More Likely to Receive Surgery in the Pandemic?

Due to the ramping down of cancer surgery in early pandemic, many newly diagnosed patients received other treatments first. We aimed to quantify the pandemic-related shift in rate of surgery following chemotherapy. This is a retrospective population-based cohort study involving adults diagnosed with...

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Autores principales: Fu, Rui, Sutradhar, Rinku, Dare, Anna, Li, Qing, Hanna, Timothy P., Chan, Kelvin K. W., Irish, Jonathan C., Coburn, Natalie, Hallet, Julie, Singh, Simron, Parmar, Ambica, Earle, Craig C., Lapointe-Shaw, Lauren, Krzyzanowska, Monika K., Finelli, Antonio, Louie, Alexander V., Witterick, Ian J., Mahar, Alyson, Urbach, David R., McIsaac, Daniel I., Enepekides, Danny, Look Hong, Nicole J., Eskander, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600641/
https://www.ncbi.nlm.nih.gov/pubmed/36290888
http://dx.doi.org/10.3390/curroncol29100611
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author Fu, Rui
Sutradhar, Rinku
Dare, Anna
Li, Qing
Hanna, Timothy P.
Chan, Kelvin K. W.
Irish, Jonathan C.
Coburn, Natalie
Hallet, Julie
Singh, Simron
Parmar, Ambica
Earle, Craig C.
Lapointe-Shaw, Lauren
Krzyzanowska, Monika K.
Finelli, Antonio
Louie, Alexander V.
Witterick, Ian J.
Mahar, Alyson
Urbach, David R.
McIsaac, Daniel I.
Enepekides, Danny
Look Hong, Nicole J.
Eskander, Antoine
author_facet Fu, Rui
Sutradhar, Rinku
Dare, Anna
Li, Qing
Hanna, Timothy P.
Chan, Kelvin K. W.
Irish, Jonathan C.
Coburn, Natalie
Hallet, Julie
Singh, Simron
Parmar, Ambica
Earle, Craig C.
Lapointe-Shaw, Lauren
Krzyzanowska, Monika K.
Finelli, Antonio
Louie, Alexander V.
Witterick, Ian J.
Mahar, Alyson
Urbach, David R.
McIsaac, Daniel I.
Enepekides, Danny
Look Hong, Nicole J.
Eskander, Antoine
author_sort Fu, Rui
collection PubMed
description Due to the ramping down of cancer surgery in early pandemic, many newly diagnosed patients received other treatments first. We aimed to quantify the pandemic-related shift in rate of surgery following chemotherapy. This is a retrospective population-based cohort study involving adults diagnosed with cancer between 3 January 2016 and 7 November 2020 in Ontario, Canada who received chemotherapy as first treatment within 6-months of diagnosis. Competing-risks regression models with interaction effects were used to quantify the association between COVID-19 period (receiving a cancer diagnosis before or on/after 15 March 2020) and receipt of surgical reSection 9-months after first chemotherapy. Among 51,653 patients, 8.5% (n = 19,558) of them ultimately underwent surgery 9-months after chemotherapy initiation. Receipt of surgery was higher during the pandemic than before (sHR 1.07, 95% CI 1.02–1.13). Material deprivation was independently associated with lower receipt of surgery (least vs. most deprived quintile: sHR 1.11, 95% CI 1.04–1.17), but did not change with the pandemic. The surgical rate increase was most pronounced for breast cancer (sHR 1.13, 95% CI 1.06–1.20). These pandemic-related shifts in cancer treatment requires further evaluations to understand the long-term consequences. Persistent material deprivation-related inequity in cancer surgical access needs to be addressed.
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spelling pubmed-96006412022-10-27 Cancer Patients First Treated with Chemotherapy: Are They More Likely to Receive Surgery in the Pandemic? Fu, Rui Sutradhar, Rinku Dare, Anna Li, Qing Hanna, Timothy P. Chan, Kelvin K. W. Irish, Jonathan C. Coburn, Natalie Hallet, Julie Singh, Simron Parmar, Ambica Earle, Craig C. Lapointe-Shaw, Lauren Krzyzanowska, Monika K. Finelli, Antonio Louie, Alexander V. Witterick, Ian J. Mahar, Alyson Urbach, David R. McIsaac, Daniel I. Enepekides, Danny Look Hong, Nicole J. Eskander, Antoine Curr Oncol Article Due to the ramping down of cancer surgery in early pandemic, many newly diagnosed patients received other treatments first. We aimed to quantify the pandemic-related shift in rate of surgery following chemotherapy. This is a retrospective population-based cohort study involving adults diagnosed with cancer between 3 January 2016 and 7 November 2020 in Ontario, Canada who received chemotherapy as first treatment within 6-months of diagnosis. Competing-risks regression models with interaction effects were used to quantify the association between COVID-19 period (receiving a cancer diagnosis before or on/after 15 March 2020) and receipt of surgical reSection 9-months after first chemotherapy. Among 51,653 patients, 8.5% (n = 19,558) of them ultimately underwent surgery 9-months after chemotherapy initiation. Receipt of surgery was higher during the pandemic than before (sHR 1.07, 95% CI 1.02–1.13). Material deprivation was independently associated with lower receipt of surgery (least vs. most deprived quintile: sHR 1.11, 95% CI 1.04–1.17), but did not change with the pandemic. The surgical rate increase was most pronounced for breast cancer (sHR 1.13, 95% CI 1.06–1.20). These pandemic-related shifts in cancer treatment requires further evaluations to understand the long-term consequences. Persistent material deprivation-related inequity in cancer surgical access needs to be addressed. MDPI 2022-10-14 /pmc/articles/PMC9600641/ /pubmed/36290888 http://dx.doi.org/10.3390/curroncol29100611 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fu, Rui
Sutradhar, Rinku
Dare, Anna
Li, Qing
Hanna, Timothy P.
Chan, Kelvin K. W.
Irish, Jonathan C.
Coburn, Natalie
Hallet, Julie
Singh, Simron
Parmar, Ambica
Earle, Craig C.
Lapointe-Shaw, Lauren
Krzyzanowska, Monika K.
Finelli, Antonio
Louie, Alexander V.
Witterick, Ian J.
Mahar, Alyson
Urbach, David R.
McIsaac, Daniel I.
Enepekides, Danny
Look Hong, Nicole J.
Eskander, Antoine
Cancer Patients First Treated with Chemotherapy: Are They More Likely to Receive Surgery in the Pandemic?
title Cancer Patients First Treated with Chemotherapy: Are They More Likely to Receive Surgery in the Pandemic?
title_full Cancer Patients First Treated with Chemotherapy: Are They More Likely to Receive Surgery in the Pandemic?
title_fullStr Cancer Patients First Treated with Chemotherapy: Are They More Likely to Receive Surgery in the Pandemic?
title_full_unstemmed Cancer Patients First Treated with Chemotherapy: Are They More Likely to Receive Surgery in the Pandemic?
title_short Cancer Patients First Treated with Chemotherapy: Are They More Likely to Receive Surgery in the Pandemic?
title_sort cancer patients first treated with chemotherapy: are they more likely to receive surgery in the pandemic?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600641/
https://www.ncbi.nlm.nih.gov/pubmed/36290888
http://dx.doi.org/10.3390/curroncol29100611
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