Cargando…
First- and Second-Line Treatments for Patients with Advanced Hepatocellular Carcinoma in China: A Systematic Review
Chinese national guidelines recommend various systemic therapies for patients with advanced hepatocellular carcinoma (HCC), but optimal treatment selection remains uncertain. To summarize the evidence supporting the systemic treatment of Chinese patients with advanced HCC, we performed a systematic...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600684/ https://www.ncbi.nlm.nih.gov/pubmed/36290852 http://dx.doi.org/10.3390/curroncol29100575 |
_version_ | 1784816904232239104 |
---|---|
author | Zhang, Lan Sun, Junhui Wang, Kui Zhao, Haitao Zhang, Xijie Ren, Zhenggang |
author_facet | Zhang, Lan Sun, Junhui Wang, Kui Zhao, Haitao Zhang, Xijie Ren, Zhenggang |
author_sort | Zhang, Lan |
collection | PubMed |
description | Chinese national guidelines recommend various systemic therapies for patients with advanced hepatocellular carcinoma (HCC), but optimal treatment selection remains uncertain. To summarize the evidence supporting the systemic treatment of Chinese patients with advanced HCC, we performed a systematic review using a literature search of PubMed, Embase, China National Knowledge Infrastructure, and the Chinese Scientific Journal Database between 1 January 2009 and 15 June 2021, and abstracts from ASCO 2020, ASCO GI 2021, ESMO 2020, and ESMO GI 2020. The inclusion criteria were: Chinese patients aged ≥18 years with advanced HCC; first- or second-line systemic therapy; an evaluation of the efficacy or safety outcomes; and a randomized controlled, non-randomized controlled, prospective, or retrospective design. Thirty reports were identified for the following therapies: the single-agent tyrosine kinase inhibitor (TKI; n = 10), single-agent programmed death-1 (PD-1) inhibitor (n = 4), chemotherapy (n = 5), PD-1/programmed death-ligand 1 (PD-L1) inhibitor plus TKI (n = 6), PD-1/PD-L1 inhibitor plus bevacizumab or biosimilar (n = 4), and PD-1/PD-L1 inhibitor plus chemotherapy (n = 1). The heterogeneity between the studies precluded statistical analysis and the data were summarized using tables. In the first-line setting, evidence supported the use of atezolizumab or sintilimab plus bevacizumab or a biosimilar. There remains insufficient evidence to determine the optimal approved TKI-based therapeutic option, and active controlled trials in the second-line setting were lacking. |
format | Online Article Text |
id | pubmed-9600684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96006842022-10-27 First- and Second-Line Treatments for Patients with Advanced Hepatocellular Carcinoma in China: A Systematic Review Zhang, Lan Sun, Junhui Wang, Kui Zhao, Haitao Zhang, Xijie Ren, Zhenggang Curr Oncol Systematic Review Chinese national guidelines recommend various systemic therapies for patients with advanced hepatocellular carcinoma (HCC), but optimal treatment selection remains uncertain. To summarize the evidence supporting the systemic treatment of Chinese patients with advanced HCC, we performed a systematic review using a literature search of PubMed, Embase, China National Knowledge Infrastructure, and the Chinese Scientific Journal Database between 1 January 2009 and 15 June 2021, and abstracts from ASCO 2020, ASCO GI 2021, ESMO 2020, and ESMO GI 2020. The inclusion criteria were: Chinese patients aged ≥18 years with advanced HCC; first- or second-line systemic therapy; an evaluation of the efficacy or safety outcomes; and a randomized controlled, non-randomized controlled, prospective, or retrospective design. Thirty reports were identified for the following therapies: the single-agent tyrosine kinase inhibitor (TKI; n = 10), single-agent programmed death-1 (PD-1) inhibitor (n = 4), chemotherapy (n = 5), PD-1/programmed death-ligand 1 (PD-L1) inhibitor plus TKI (n = 6), PD-1/PD-L1 inhibitor plus bevacizumab or biosimilar (n = 4), and PD-1/PD-L1 inhibitor plus chemotherapy (n = 1). The heterogeneity between the studies precluded statistical analysis and the data were summarized using tables. In the first-line setting, evidence supported the use of atezolizumab or sintilimab plus bevacizumab or a biosimilar. There remains insufficient evidence to determine the optimal approved TKI-based therapeutic option, and active controlled trials in the second-line setting were lacking. MDPI 2022-09-30 /pmc/articles/PMC9600684/ /pubmed/36290852 http://dx.doi.org/10.3390/curroncol29100575 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Zhang, Lan Sun, Junhui Wang, Kui Zhao, Haitao Zhang, Xijie Ren, Zhenggang First- and Second-Line Treatments for Patients with Advanced Hepatocellular Carcinoma in China: A Systematic Review |
title | First- and Second-Line Treatments for Patients with Advanced Hepatocellular Carcinoma in China: A Systematic Review |
title_full | First- and Second-Line Treatments for Patients with Advanced Hepatocellular Carcinoma in China: A Systematic Review |
title_fullStr | First- and Second-Line Treatments for Patients with Advanced Hepatocellular Carcinoma in China: A Systematic Review |
title_full_unstemmed | First- and Second-Line Treatments for Patients with Advanced Hepatocellular Carcinoma in China: A Systematic Review |
title_short | First- and Second-Line Treatments for Patients with Advanced Hepatocellular Carcinoma in China: A Systematic Review |
title_sort | first- and second-line treatments for patients with advanced hepatocellular carcinoma in china: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600684/ https://www.ncbi.nlm.nih.gov/pubmed/36290852 http://dx.doi.org/10.3390/curroncol29100575 |
work_keys_str_mv | AT zhanglan firstandsecondlinetreatmentsforpatientswithadvancedhepatocellularcarcinomainchinaasystematicreview AT sunjunhui firstandsecondlinetreatmentsforpatientswithadvancedhepatocellularcarcinomainchinaasystematicreview AT wangkui firstandsecondlinetreatmentsforpatientswithadvancedhepatocellularcarcinomainchinaasystematicreview AT zhaohaitao firstandsecondlinetreatmentsforpatientswithadvancedhepatocellularcarcinomainchinaasystematicreview AT zhangxijie firstandsecondlinetreatmentsforpatientswithadvancedhepatocellularcarcinomainchinaasystematicreview AT renzhenggang firstandsecondlinetreatmentsforpatientswithadvancedhepatocellularcarcinomainchinaasystematicreview |