Cargando…
A Combined Angelica gigas and Artemisia dracunculus Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway
Since skeletal muscle atrophy resulting from various causes accelerates the progression of several diseases, its prevention should help maintain health and quality of life. A range of natural materials have been investigated for their potential preventive effects against muscle atrophy. Here, ethano...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600779/ https://www.ncbi.nlm.nih.gov/pubmed/36291111 http://dx.doi.org/10.3390/cells11203245 |
_version_ | 1784816928333758464 |
---|---|
author | Oh, Hyun-Ji Jin, Heegu Kim, Byung-Yong Lee, Ok-Hwan Lee, Boo-Yong |
author_facet | Oh, Hyun-Ji Jin, Heegu Kim, Byung-Yong Lee, Ok-Hwan Lee, Boo-Yong |
author_sort | Oh, Hyun-Ji |
collection | PubMed |
description | Since skeletal muscle atrophy resulting from various causes accelerates the progression of several diseases, its prevention should help maintain health and quality of life. A range of natural materials have been investigated for their potential preventive effects against muscle atrophy. Here, ethanol extracts of Angelica gigas and Artemisia dracunculus were concentrated and dried, and mixed at a ratio of 7:3 to create the mixture CHDT. We then evaluated the potential for CHDT to prevent muscle atrophy and explored the mechanisms involved. CHDT was orally administered to C57BL/6 mice daily for 30 days, and dexamethasone (Dex) was intraperitoneally injected daily to induce muscle atrophy from 14 days after the start of oral administration. We found that CHDT prevented the Dex-induced reductions in muscle strength, mass, and fiber size, likely by upregulating the Akt/mTOR signaling pathway. In addition, CHDT reduced the Dex-induced increase in the serum concentrations of pro-inflammatory cytokines, which directly induce the degradation of muscle proteins. These findings suggest that CHDT could serve as a natural food supplement for the prevention of muscle atrophy. |
format | Online Article Text |
id | pubmed-9600779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96007792022-10-27 A Combined Angelica gigas and Artemisia dracunculus Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway Oh, Hyun-Ji Jin, Heegu Kim, Byung-Yong Lee, Ok-Hwan Lee, Boo-Yong Cells Article Since skeletal muscle atrophy resulting from various causes accelerates the progression of several diseases, its prevention should help maintain health and quality of life. A range of natural materials have been investigated for their potential preventive effects against muscle atrophy. Here, ethanol extracts of Angelica gigas and Artemisia dracunculus were concentrated and dried, and mixed at a ratio of 7:3 to create the mixture CHDT. We then evaluated the potential for CHDT to prevent muscle atrophy and explored the mechanisms involved. CHDT was orally administered to C57BL/6 mice daily for 30 days, and dexamethasone (Dex) was intraperitoneally injected daily to induce muscle atrophy from 14 days after the start of oral administration. We found that CHDT prevented the Dex-induced reductions in muscle strength, mass, and fiber size, likely by upregulating the Akt/mTOR signaling pathway. In addition, CHDT reduced the Dex-induced increase in the serum concentrations of pro-inflammatory cytokines, which directly induce the degradation of muscle proteins. These findings suggest that CHDT could serve as a natural food supplement for the prevention of muscle atrophy. MDPI 2022-10-15 /pmc/articles/PMC9600779/ /pubmed/36291111 http://dx.doi.org/10.3390/cells11203245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Oh, Hyun-Ji Jin, Heegu Kim, Byung-Yong Lee, Ok-Hwan Lee, Boo-Yong A Combined Angelica gigas and Artemisia dracunculus Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
title | A Combined Angelica gigas and Artemisia dracunculus Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
title_full | A Combined Angelica gigas and Artemisia dracunculus Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
title_fullStr | A Combined Angelica gigas and Artemisia dracunculus Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
title_full_unstemmed | A Combined Angelica gigas and Artemisia dracunculus Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
title_short | A Combined Angelica gigas and Artemisia dracunculus Extract Prevents Dexamethasone-Induced Muscle Atrophy in Mice through the Akt/mTOR/FoxO3a Signaling Pathway |
title_sort | combined angelica gigas and artemisia dracunculus extract prevents dexamethasone-induced muscle atrophy in mice through the akt/mtor/foxo3a signaling pathway |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600779/ https://www.ncbi.nlm.nih.gov/pubmed/36291111 http://dx.doi.org/10.3390/cells11203245 |
work_keys_str_mv | AT ohhyunji acombinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway AT jinheegu acombinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway AT kimbyungyong acombinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway AT leeokhwan acombinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway AT leebooyong acombinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway AT ohhyunji combinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway AT jinheegu combinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway AT kimbyungyong combinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway AT leeokhwan combinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway AT leebooyong combinedangelicagigasandartemisiadracunculusextractpreventsdexamethasoneinducedmuscleatrophyinmicethroughtheaktmtorfoxo3asignalingpathway |