High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages

Diabetes mellitus (DM) increases the risk of developing tuberculosis (TB), but the mechanisms behind diabetes-TB comorbidity are still undefined. Here, we studied the role of hypoxia-inducible factor-1 (HIF-1), a main regulator of metabolic and inflammatory responses, in the outcome of Mycobacterium...

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Detalles Bibliográficos
Autores principales: Terán, Graciela, Li, Hanxiong, Catrina, Sergiu-Bogdan, Liu, Ruining, Brighenti, Susanna, Zheng, Xiaowei, Grünler, Jakob, Nylén, Susanne, Carow, Berit, Rottenberg, Martin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600926/
https://www.ncbi.nlm.nih.gov/pubmed/36121152
http://dx.doi.org/10.1128/mbio.01086-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600926/
https://www.ncbi.nlm.nih.gov/pubmed/36121152
http://dx.doi.org/10.1128/mbio.01086-22

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