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Deciphering the Microbiome: Integrating Theory, New Technologies, and Inclusive Science
The diversity and functional significance of microbiomes have become increasingly clear through the extensive sampling of Earth's many habitats and the rapid adoption of new sequencing technologies. However, much remains unknown about what makes a “healthy” microbiome, how to restore a disrupte...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600927/ https://www.ncbi.nlm.nih.gov/pubmed/36073805 http://dx.doi.org/10.1128/msystems.00583-22 |
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author | Milligan-McClellan, Kathryn C. Dundore-Arias, José Pablo Klassen, Jonathan L. Shade, Ashley Kinkel, Linda L. Wolfe, Benjamin E. |
author_facet | Milligan-McClellan, Kathryn C. Dundore-Arias, José Pablo Klassen, Jonathan L. Shade, Ashley Kinkel, Linda L. Wolfe, Benjamin E. |
author_sort | Milligan-McClellan, Kathryn C. |
collection | PubMed |
description | The diversity and functional significance of microbiomes have become increasingly clear through the extensive sampling of Earth's many habitats and the rapid adoption of new sequencing technologies. However, much remains unknown about what makes a “healthy” microbiome, how to restore a disrupted microbiome, and how microbiomes assemble. In December 2019, we convened a workshop that focused on how to identify potential “rules of life” that govern microbiome structure and function. This collection of mSystems Perspective pieces reflects many of the main challenges and opportunities in the field identified by both in-person and virtual workshop participants. By borrowing conceptual and theoretical approaches from other fields, including economics and philosophy, these pieces suggest new ways to dissect microbiome patterns and processes. The application of conceptual advances, including trait-based theory and community coalescence, is providing new insights on how to predict and manage microbiome diversity and function. Technological and analytical advances, including deep transfer learning, metabolic models, and advances in analytical chemistry, are helping us sift through complex systems to pinpoint mechanisms of microbiome assembly and dynamics. Integration of all of these advancements (theory, concepts, technology) across biological and spatial scales is providing dramatically improved temporal and spatial resolution of microbiome dynamics. This integrative microbiome research is happening in a new moment in science where academic institutions, scientific societies, and funding agencies must act collaboratively to support and train a diverse and inclusive community of microbiome scientists. |
format | Online Article Text |
id | pubmed-9600927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-96009272022-10-27 Deciphering the Microbiome: Integrating Theory, New Technologies, and Inclusive Science Milligan-McClellan, Kathryn C. Dundore-Arias, José Pablo Klassen, Jonathan L. Shade, Ashley Kinkel, Linda L. Wolfe, Benjamin E. mSystems Editorial The diversity and functional significance of microbiomes have become increasingly clear through the extensive sampling of Earth's many habitats and the rapid adoption of new sequencing technologies. However, much remains unknown about what makes a “healthy” microbiome, how to restore a disrupted microbiome, and how microbiomes assemble. In December 2019, we convened a workshop that focused on how to identify potential “rules of life” that govern microbiome structure and function. This collection of mSystems Perspective pieces reflects many of the main challenges and opportunities in the field identified by both in-person and virtual workshop participants. By borrowing conceptual and theoretical approaches from other fields, including economics and philosophy, these pieces suggest new ways to dissect microbiome patterns and processes. The application of conceptual advances, including trait-based theory and community coalescence, is providing new insights on how to predict and manage microbiome diversity and function. Technological and analytical advances, including deep transfer learning, metabolic models, and advances in analytical chemistry, are helping us sift through complex systems to pinpoint mechanisms of microbiome assembly and dynamics. Integration of all of these advancements (theory, concepts, technology) across biological and spatial scales is providing dramatically improved temporal and spatial resolution of microbiome dynamics. This integrative microbiome research is happening in a new moment in science where academic institutions, scientific societies, and funding agencies must act collaboratively to support and train a diverse and inclusive community of microbiome scientists. American Society for Microbiology 2022-09-08 /pmc/articles/PMC9600927/ /pubmed/36073805 http://dx.doi.org/10.1128/msystems.00583-22 Text en Copyright © 2022 Milligan-McClellan et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Editorial Milligan-McClellan, Kathryn C. Dundore-Arias, José Pablo Klassen, Jonathan L. Shade, Ashley Kinkel, Linda L. Wolfe, Benjamin E. Deciphering the Microbiome: Integrating Theory, New Technologies, and Inclusive Science |
title | Deciphering the Microbiome: Integrating Theory, New Technologies, and Inclusive Science |
title_full | Deciphering the Microbiome: Integrating Theory, New Technologies, and Inclusive Science |
title_fullStr | Deciphering the Microbiome: Integrating Theory, New Technologies, and Inclusive Science |
title_full_unstemmed | Deciphering the Microbiome: Integrating Theory, New Technologies, and Inclusive Science |
title_short | Deciphering the Microbiome: Integrating Theory, New Technologies, and Inclusive Science |
title_sort | deciphering the microbiome: integrating theory, new technologies, and inclusive science |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600927/ https://www.ncbi.nlm.nih.gov/pubmed/36073805 http://dx.doi.org/10.1128/msystems.00583-22 |
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