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Prognostic Value of Late Gadolinium Enhancement in Left Ventricular Noncompaction: A Multicenter Study

Current diagnostic criteria for left ventricular noncompaction (LVNC) may be poorly related to adverse prognosis. Late gadolinium enhancement (LGE) is a predictor of major adverse cardiovascular events (MACE), but risk stratification of LGE in patients with LVNC remains unclear. We retrospectively a...

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Autores principales: Huang, Wei, Sun, Ran, Liu, Wenbin, Xu, Rong, Zhou, Ziqi, Bai, Wei, Hou, Ruilai, Xu, Huayan, Guo, Yingkun, Yu, Li, Ye, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600954/
https://www.ncbi.nlm.nih.gov/pubmed/36292149
http://dx.doi.org/10.3390/diagnostics12102457
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author Huang, Wei
Sun, Ran
Liu, Wenbin
Xu, Rong
Zhou, Ziqi
Bai, Wei
Hou, Ruilai
Xu, Huayan
Guo, Yingkun
Yu, Li
Ye, Lu
author_facet Huang, Wei
Sun, Ran
Liu, Wenbin
Xu, Rong
Zhou, Ziqi
Bai, Wei
Hou, Ruilai
Xu, Huayan
Guo, Yingkun
Yu, Li
Ye, Lu
author_sort Huang, Wei
collection PubMed
description Current diagnostic criteria for left ventricular noncompaction (LVNC) may be poorly related to adverse prognosis. Late gadolinium enhancement (LGE) is a predictor of major adverse cardiovascular events (MACE), but risk stratification of LGE in patients with LVNC remains unclear. We retrospectively analyzed the clinical and cardiovascular magnetic resonance (CMR) data of 75 patients from three institutes and examined the correlation between different LGE types and MACE based on the extent, pattern (including a specific ring-like pattern), and locations of LGE in LVNC. A total of 51 patients (68%) presented LGE. A specific ring-like pattern was observed in 9 (12%). MACE occurred in 29 (38.7%) at 4.3 years of follow-up (interquartile range: 2.1–5.7 years). The adjusted hazard ratio (HR) for patients with ring-like LGE were 6.10 (95% CI, 1.39–26.75, p < 0.05). Free-wall or mid-wall LGE was associated with an increased risk of MACE after adjustment (HR 2.85, 95% CI, 1.31–6.21; HR 4.35, 95% CI, 1.23–15.37, respectively, p < 0.05). The risk of MACE in LVNC significantly increased when the LGE extent was greater than 7.5% and ring-like, multiple segments, and free-wall LGE were associated with MACE. These results suggest the value of LGE risk stratification in patients with LVNC.
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spelling pubmed-96009542022-10-27 Prognostic Value of Late Gadolinium Enhancement in Left Ventricular Noncompaction: A Multicenter Study Huang, Wei Sun, Ran Liu, Wenbin Xu, Rong Zhou, Ziqi Bai, Wei Hou, Ruilai Xu, Huayan Guo, Yingkun Yu, Li Ye, Lu Diagnostics (Basel) Article Current diagnostic criteria for left ventricular noncompaction (LVNC) may be poorly related to adverse prognosis. Late gadolinium enhancement (LGE) is a predictor of major adverse cardiovascular events (MACE), but risk stratification of LGE in patients with LVNC remains unclear. We retrospectively analyzed the clinical and cardiovascular magnetic resonance (CMR) data of 75 patients from three institutes and examined the correlation between different LGE types and MACE based on the extent, pattern (including a specific ring-like pattern), and locations of LGE in LVNC. A total of 51 patients (68%) presented LGE. A specific ring-like pattern was observed in 9 (12%). MACE occurred in 29 (38.7%) at 4.3 years of follow-up (interquartile range: 2.1–5.7 years). The adjusted hazard ratio (HR) for patients with ring-like LGE were 6.10 (95% CI, 1.39–26.75, p < 0.05). Free-wall or mid-wall LGE was associated with an increased risk of MACE after adjustment (HR 2.85, 95% CI, 1.31–6.21; HR 4.35, 95% CI, 1.23–15.37, respectively, p < 0.05). The risk of MACE in LVNC significantly increased when the LGE extent was greater than 7.5% and ring-like, multiple segments, and free-wall LGE were associated with MACE. These results suggest the value of LGE risk stratification in patients with LVNC. MDPI 2022-10-11 /pmc/articles/PMC9600954/ /pubmed/36292149 http://dx.doi.org/10.3390/diagnostics12102457 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Wei
Sun, Ran
Liu, Wenbin
Xu, Rong
Zhou, Ziqi
Bai, Wei
Hou, Ruilai
Xu, Huayan
Guo, Yingkun
Yu, Li
Ye, Lu
Prognostic Value of Late Gadolinium Enhancement in Left Ventricular Noncompaction: A Multicenter Study
title Prognostic Value of Late Gadolinium Enhancement in Left Ventricular Noncompaction: A Multicenter Study
title_full Prognostic Value of Late Gadolinium Enhancement in Left Ventricular Noncompaction: A Multicenter Study
title_fullStr Prognostic Value of Late Gadolinium Enhancement in Left Ventricular Noncompaction: A Multicenter Study
title_full_unstemmed Prognostic Value of Late Gadolinium Enhancement in Left Ventricular Noncompaction: A Multicenter Study
title_short Prognostic Value of Late Gadolinium Enhancement in Left Ventricular Noncompaction: A Multicenter Study
title_sort prognostic value of late gadolinium enhancement in left ventricular noncompaction: a multicenter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600954/
https://www.ncbi.nlm.nih.gov/pubmed/36292149
http://dx.doi.org/10.3390/diagnostics12102457
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