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Ureaplasma parvum Septic Arthritis, a Clinic Challenge

Ureaplasma parvum is usually part of the normal genital microbiota. Rarely, it can cause invasive infections such as septic arthritis or meningitis. A case of a 74-year-old woman with follicular lymphoma who developed cellulitis followed by elbow arthritis with negative routine bacterial cultures is...

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Autores principales: Suárez-Cuervo, Carlos, Nicolás, Concepción, Fernández-Suárez, Jonathan, Morilla, Ana, Fernández, Javier, Caminal-Montero, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600973/
https://www.ncbi.nlm.nih.gov/pubmed/36292105
http://dx.doi.org/10.3390/diagnostics12102416
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author Suárez-Cuervo, Carlos
Nicolás, Concepción
Fernández-Suárez, Jonathan
Morilla, Ana
Fernández, Javier
Caminal-Montero, Luis
author_facet Suárez-Cuervo, Carlos
Nicolás, Concepción
Fernández-Suárez, Jonathan
Morilla, Ana
Fernández, Javier
Caminal-Montero, Luis
author_sort Suárez-Cuervo, Carlos
collection PubMed
description Ureaplasma parvum is usually part of the normal genital microbiota. Rarely, it can cause invasive infections such as septic arthritis or meningitis. A case of a 74-year-old woman with follicular lymphoma who developed cellulitis followed by elbow arthritis with negative routine bacterial cultures is described. U. parvum was identified in the synovial fluid using a broad-range 16S ribosomal RNA gene polymerase chain reaction (PCR) and also in vaginal fluid by a targeted PCR (Anyplex™ II STI-7). Multilocus Sequence Typing (MLST) revealed that isolates from both sources belonged to ST4, a worldwide distributed clone. Treatment consisted of surgery and targeted antibiotic therapy with doxycycline and azithromycin. Evolution showed initial clinical improvement in arthritis despite functional sequelae. Ureaplasma arthritis should be considered as a rare cause of arthritis in negative culture, especially in immunosuppressed patients. In these cases, the treatment is not well established, but according to this and previous works, patients could improve with doxycycline, azithromycin or fluoroquinolone therapy on a prolonged basis.
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spelling pubmed-96009732022-10-27 Ureaplasma parvum Septic Arthritis, a Clinic Challenge Suárez-Cuervo, Carlos Nicolás, Concepción Fernández-Suárez, Jonathan Morilla, Ana Fernández, Javier Caminal-Montero, Luis Diagnostics (Basel) Case Report Ureaplasma parvum is usually part of the normal genital microbiota. Rarely, it can cause invasive infections such as septic arthritis or meningitis. A case of a 74-year-old woman with follicular lymphoma who developed cellulitis followed by elbow arthritis with negative routine bacterial cultures is described. U. parvum was identified in the synovial fluid using a broad-range 16S ribosomal RNA gene polymerase chain reaction (PCR) and also in vaginal fluid by a targeted PCR (Anyplex™ II STI-7). Multilocus Sequence Typing (MLST) revealed that isolates from both sources belonged to ST4, a worldwide distributed clone. Treatment consisted of surgery and targeted antibiotic therapy with doxycycline and azithromycin. Evolution showed initial clinical improvement in arthritis despite functional sequelae. Ureaplasma arthritis should be considered as a rare cause of arthritis in negative culture, especially in immunosuppressed patients. In these cases, the treatment is not well established, but according to this and previous works, patients could improve with doxycycline, azithromycin or fluoroquinolone therapy on a prolonged basis. MDPI 2022-10-06 /pmc/articles/PMC9600973/ /pubmed/36292105 http://dx.doi.org/10.3390/diagnostics12102416 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Suárez-Cuervo, Carlos
Nicolás, Concepción
Fernández-Suárez, Jonathan
Morilla, Ana
Fernández, Javier
Caminal-Montero, Luis
Ureaplasma parvum Septic Arthritis, a Clinic Challenge
title Ureaplasma parvum Septic Arthritis, a Clinic Challenge
title_full Ureaplasma parvum Septic Arthritis, a Clinic Challenge
title_fullStr Ureaplasma parvum Septic Arthritis, a Clinic Challenge
title_full_unstemmed Ureaplasma parvum Septic Arthritis, a Clinic Challenge
title_short Ureaplasma parvum Septic Arthritis, a Clinic Challenge
title_sort ureaplasma parvum septic arthritis, a clinic challenge
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600973/
https://www.ncbi.nlm.nih.gov/pubmed/36292105
http://dx.doi.org/10.3390/diagnostics12102416
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