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Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study

Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270...

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Autores principales: Ota, Takeshi, Mori, Jun, Kawabe, Yasuhiro, Morimoto, Hidechika, Fukuhara, Shota, Kodo, Kazuki, Sugimoto, Satoru, Kosaka, Kitaro, Nakajima, Hisakazu, Hosoi, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600981/
https://www.ncbi.nlm.nih.gov/pubmed/36291357
http://dx.doi.org/10.3390/children9101421
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author Ota, Takeshi
Mori, Jun
Kawabe, Yasuhiro
Morimoto, Hidechika
Fukuhara, Shota
Kodo, Kazuki
Sugimoto, Satoru
Kosaka, Kitaro
Nakajima, Hisakazu
Hosoi, Hajime
author_facet Ota, Takeshi
Mori, Jun
Kawabe, Yasuhiro
Morimoto, Hidechika
Fukuhara, Shota
Kodo, Kazuki
Sugimoto, Satoru
Kosaka, Kitaro
Nakajima, Hisakazu
Hosoi, Hajime
author_sort Ota, Takeshi
collection PubMed
description Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270 non-obese and 86 obese children. All participants underwent genotyping for type 2 deiodinase (DIO2) Thr92Ala (rs225014). The prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1% versus 6.3% in the non-obese group, resulting in an odds ratio (OR) of 3.393 (p = 0.003). The results of this study indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of pediatric obesity and suggest that pediatric obesity might be suitable for assessing the association with gene polymorphisms related to BAT, especially DIO2 Thr92Ala.
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spelling pubmed-96009812022-10-27 Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study Ota, Takeshi Mori, Jun Kawabe, Yasuhiro Morimoto, Hidechika Fukuhara, Shota Kodo, Kazuki Sugimoto, Satoru Kosaka, Kitaro Nakajima, Hisakazu Hosoi, Hajime Children (Basel) Article Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270 non-obese and 86 obese children. All participants underwent genotyping for type 2 deiodinase (DIO2) Thr92Ala (rs225014). The prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1% versus 6.3% in the non-obese group, resulting in an odds ratio (OR) of 3.393 (p = 0.003). The results of this study indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of pediatric obesity and suggest that pediatric obesity might be suitable for assessing the association with gene polymorphisms related to BAT, especially DIO2 Thr92Ala. MDPI 2022-09-20 /pmc/articles/PMC9600981/ /pubmed/36291357 http://dx.doi.org/10.3390/children9101421 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ota, Takeshi
Mori, Jun
Kawabe, Yasuhiro
Morimoto, Hidechika
Fukuhara, Shota
Kodo, Kazuki
Sugimoto, Satoru
Kosaka, Kitaro
Nakajima, Hisakazu
Hosoi, Hajime
Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study
title Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study
title_full Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study
title_fullStr Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study
title_full_unstemmed Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study
title_short Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study
title_sort association of type 2 deiodinase thr92ala polymorphism with pediatric obesity in japanese children: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600981/
https://www.ncbi.nlm.nih.gov/pubmed/36291357
http://dx.doi.org/10.3390/children9101421
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