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Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study
Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600981/ https://www.ncbi.nlm.nih.gov/pubmed/36291357 http://dx.doi.org/10.3390/children9101421 |
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author | Ota, Takeshi Mori, Jun Kawabe, Yasuhiro Morimoto, Hidechika Fukuhara, Shota Kodo, Kazuki Sugimoto, Satoru Kosaka, Kitaro Nakajima, Hisakazu Hosoi, Hajime |
author_facet | Ota, Takeshi Mori, Jun Kawabe, Yasuhiro Morimoto, Hidechika Fukuhara, Shota Kodo, Kazuki Sugimoto, Satoru Kosaka, Kitaro Nakajima, Hisakazu Hosoi, Hajime |
author_sort | Ota, Takeshi |
collection | PubMed |
description | Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270 non-obese and 86 obese children. All participants underwent genotyping for type 2 deiodinase (DIO2) Thr92Ala (rs225014). The prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1% versus 6.3% in the non-obese group, resulting in an odds ratio (OR) of 3.393 (p = 0.003). The results of this study indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of pediatric obesity and suggest that pediatric obesity might be suitable for assessing the association with gene polymorphisms related to BAT, especially DIO2 Thr92Ala. |
format | Online Article Text |
id | pubmed-9600981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96009812022-10-27 Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study Ota, Takeshi Mori, Jun Kawabe, Yasuhiro Morimoto, Hidechika Fukuhara, Shota Kodo, Kazuki Sugimoto, Satoru Kosaka, Kitaro Nakajima, Hisakazu Hosoi, Hajime Children (Basel) Article Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270 non-obese and 86 obese children. All participants underwent genotyping for type 2 deiodinase (DIO2) Thr92Ala (rs225014). The prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1% versus 6.3% in the non-obese group, resulting in an odds ratio (OR) of 3.393 (p = 0.003). The results of this study indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of pediatric obesity and suggest that pediatric obesity might be suitable for assessing the association with gene polymorphisms related to BAT, especially DIO2 Thr92Ala. MDPI 2022-09-20 /pmc/articles/PMC9600981/ /pubmed/36291357 http://dx.doi.org/10.3390/children9101421 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ota, Takeshi Mori, Jun Kawabe, Yasuhiro Morimoto, Hidechika Fukuhara, Shota Kodo, Kazuki Sugimoto, Satoru Kosaka, Kitaro Nakajima, Hisakazu Hosoi, Hajime Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
title | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
title_full | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
title_fullStr | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
title_full_unstemmed | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
title_short | Association of Type 2 Deiodinase Thr92Ala Polymorphism with Pediatric Obesity in Japanese Children: A Case-Control Study |
title_sort | association of type 2 deiodinase thr92ala polymorphism with pediatric obesity in japanese children: a case-control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600981/ https://www.ncbi.nlm.nih.gov/pubmed/36291357 http://dx.doi.org/10.3390/children9101421 |
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