Boron Neutron Capture Therapy: Clinical Application and Research Progress

Boron neutron capture therapy (BNCT) is a binary modality that is used to treat a variety of malignancies, using neutrons to irradiate boron-10 ((10)B) nuclei that have entered tumor cells to produce highly linear energy transfer (LET) alpha particles and recoil (7)Li nuclei ((10)B [n, α] (7)Li). Therefore, the most important part in BNCT is to selectively deliver a large number of (10)B to tumor cells and only a small amount to normal tissue. So far, BNCT has been used in more than 2000 cases worldwide, and the efficacy of BNCT in the treatment of head and neck cancer, malignant meningioma, melanoma and hepatocellular carcinoma has been confirmed. We collected and collated clinical studies of second-generation boron delivery agents. The combination of different drugs, the mode of administration, and the combination of multiple treatments have an important impact on patient survival. We summarized the critical issues that must be addressed, with the hope that the next generation of boron delivery agents will overcome these challenges.