The Contribution of Lipotoxicity to Diabetic Kidney Disease

Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) pathogenesis. This review highlights lipotoxicity pathways in the podocyte and proximal tubule cell, which are arguably the t...

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Detalles Bibliográficos
Autor principal: Schelling, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601125/
https://www.ncbi.nlm.nih.gov/pubmed/36291104
http://dx.doi.org/10.3390/cells11203236
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author Schelling, Jeffrey R.
author_facet Schelling, Jeffrey R.
author_sort Schelling, Jeffrey R.
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description Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) pathogenesis. This review highlights lipotoxicity pathways in the podocyte and proximal tubule cell, which are arguably the two most critical sites in the nephron for DKD. The discussion focuses on membrane transporters and lipid droplets, which represent potential therapeutic targets, as well as current and developing pharmacologic approaches to reduce renal lipotoxicity.
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spelling pubmed-96011252022-10-27 The Contribution of Lipotoxicity to Diabetic Kidney Disease Schelling, Jeffrey R. Cells Review Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) pathogenesis. This review highlights lipotoxicity pathways in the podocyte and proximal tubule cell, which are arguably the two most critical sites in the nephron for DKD. The discussion focuses on membrane transporters and lipid droplets, which represent potential therapeutic targets, as well as current and developing pharmacologic approaches to reduce renal lipotoxicity. MDPI 2022-10-14 /pmc/articles/PMC9601125/ /pubmed/36291104 http://dx.doi.org/10.3390/cells11203236 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schelling, Jeffrey R.
The Contribution of Lipotoxicity to Diabetic Kidney Disease
title The Contribution of Lipotoxicity to Diabetic Kidney Disease
title_full The Contribution of Lipotoxicity to Diabetic Kidney Disease
title_fullStr The Contribution of Lipotoxicity to Diabetic Kidney Disease
title_full_unstemmed The Contribution of Lipotoxicity to Diabetic Kidney Disease
title_short The Contribution of Lipotoxicity to Diabetic Kidney Disease
title_sort contribution of lipotoxicity to diabetic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601125/
https://www.ncbi.nlm.nih.gov/pubmed/36291104
http://dx.doi.org/10.3390/cells11203236
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